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Medicine

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Genomics, Type 2 Diabetes, Endocrinology, GWAS, Genetics, susceptibility locus, CRISPR, chromosome conformation capture , Children's Hospital Of Philadelphia

Study Points to a Novel Culprit Type 2 Diabetes Gene at a Well-Established Genomic Location

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Gene researchers have used sophisticated scientific tools to reveal a new gene for type 2 diabetes at a well-established genomic location. Because this gene codes for a protein that regulates how the body recognizes insulin, that protein may represent an important target for future treatments for the disease.

Medicine

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Prediabetes, dysglysemia, early origins, Prematurity, extremely low birth weight, lean mass

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 2-Sep-2016 12:05 AM EDT

Medicine

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Diabetes, Protein, Insulin, Type 1 And 2 Diabetes, Cell Signaling

Case Western Reserve University Researchers Identify Protein that Delays Type 1 Diabetes Onset in New Mouse Model

A new study reveals a counterintuitive cellular strategy that may protect insulin-producing cells from destruction during type 1 diabetes.

Medicine

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Blood Sugar, Diabetes Complications, diabetes treatment, Endocrinology, evidence based med, Glycemic Control, Medical Research, Minnesota News Release, news release, re, Type 2 Diabetes

Tight Focus on Blood Sugar Narrows Options for Diabetes Complications

ROCHESTER, Minn. – The glucocentric focus on lowering blood sugar in Type 2 diabetes may have short-circuited development of new diabetes therapies, according to a new paper published by Mayo Clinic researchers in the journal Circulation: Cardiovascular Quality and Outcomes.

Science

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Obesity, Prescription, Weight Loss, Diabetes

Doctors Prescribe Diabetes Treatment Medications 15 Times More Than Obesity Drugs, Study Finds

Obesity is a well-established major risk factor for developing diabetes, with almost 90% of people living with type 2 diabetes having obesity or overweight. Even with the close tie between obesity and type 2 diabetes, new research shows that healthcare clinicians prescribe 15 times more antidiabetes medications than those for obesity. Although six antiobesity medications are now approved by the Food and Drug Administration (FDA) for treating obesity when combined with a reduced-calorie diet and increased physical activity, this research points out that only 2% of the eligible 46% of the U.S. adult population is receiving these medications. The research is published in the September issue of Obesity, the scientific journal of The Obesity Society.

Medicine

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Telemedicine, Eye Exam, electronic health, Diabetes, diabetetic retinopathy, Blindness, Vision Screening

Telemedicine Could Improve Eye Exam Access for People with Diabetes

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People with diabetes need vision screening every year to prevent blindness. What if the eye doctor came to them?

Science

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Finding New Targets to Treat Vascular Damage

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There are no established drugs to improve angiogenesis in diabetes. However, researchers at Joslin Diabetes Center now have identified a gene called CITED2 in a molecular pathway that may offer targets for drugs that treat these conditions by strengthening angiogenesis.

Science

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Mtor, Cancer, Metabolism Pathway, Diabetes, Glucose, Glutamine, hexosamine, Metabolites, osteoarthitis, Rutgers, Rutgers Biomedical and Health Sciences, Rutgers Robert Wood Johnson Medical School

Rutgers Study Could Be First Step to Prevent Fuel Supply That Feeds Cells in Cancer, Diabetes

Rutgers researchers discovered that mTOR responds to decreasing levels of nutrients, acting as “traffic control” to help stabilize cells as nutrient intake fluctuates. The study is the first to indicate that mTOR actively participates in the process to restore cell stability when there are not enough nutrients to fuel cell growth.

Medicine

Science

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Obesity, Type 2 Diabetes, Brown Fat, beige fat, Metabolism

Calorie-Burning ‘Good’ Fat Can Be Protected, Says Study

Preventing cells of beige fat — a calorie-burning tissue that can help to ward off obesity and diabetes — from digesting their own mitochondria traps them in a beneficial, energy-burning state. In mice, this successfully protected against obesity and pre-diabetic symptoms, raising hopes for future applications in human patients.

Science

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Metabolic Disease, Obesity, Diabetes, Nonalcoholic Fatty Liver Disease, Glucoccorticoids, Steroid Medication, Steroid Hormone Treatment, Autoimmune Disease, chronic inflammatory disease

Feast or Famine: The Switch That Helps Your Liver Adapt

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Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a previously unknown way that stress hormones (glucocorticoids) control genes in the liver to help the body adapt to the fasting state. The study, published today in Cell Metabolism, describes an obscure protein, SETDB2, that’s increased during times of fasting and alters the genome to help turn on genes needed to adjust to the absence of food.

Medicine

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Ut Southwestern, utsw, Ut Southwestern Medical Center, Diabetes, Diabetes & Endocrinology, Fat Cells, Endurance Athletes, Obesity, obesity and diabetes

UT Southwestern Research Identifies Protein That Promotes the Breakdown of Fat, Potentially Leading to New Diabetes Treatments

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Researchers at UT Southwestern Medical Center have found that a protein often located on the surface of fat droplets within cells – and especially abundant in the muscles of endurance athletes – can kick-start the more efficient and healthful breakdown of fat.

Medicine

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Mount Sinai Health System, Diabetes

Diets Avoiding Dry-Cooked Foods Can Protect Against Diabetes, Say Mount Sinai Researchers

Simple changes in how we cook could go a long way towards preventing diabetes, say researchers at the Icahn School of Medicine at Mount Sinai.

Science

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Chemistry/Physics/Materials Sciences, Biology, Medicine/Health (Diabetes)

Insulin Pill Could Make Diabetes Treatment ‘Ouchless’


Every day, millions of Americans with diabetes have to inject themselves with insulin to manage their blood-sugar levels. But less painful alternatives are emerging. Scientists are developing a new way of administering the medicine orally with tiny vesicles that can deliver insulin where it needs to go without a shot. Today, they share their in vivo testing results.

Medicine

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Aging, Aging and Disease, Biology, Evolution, genetics and aging, Minorities, Medicine And Health

Resolving the 'Hispanic Paradox'

A new paper co-authored by a UC Santa Barbara researcher reveals that Latinos age at a slower rate than other ethnic groups. The findings, published in the current issue of Genome Biology, may one day help scientists understand how to slow the aging process for everyone.

Medicine

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Diabetes, IVD, intevertebral disc degeneration, Type 2 Diabetes, Diet, age, high-fat, processed foods, Deepak Vashishth, James Iatridis, Rensselaer, Biotechnology

Diet and Back Pain: What’s the Link?

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In a collaboration between Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai, researchers are exploring the link between diet, obesity-linked Type 2 diabetes, and intervertebral disc degeneration.

Medicine

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Diabetes, Health, Vision Loss, Blindness

Study Finds Vision Loss Due to Diabetes Is Rising Globally

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Research published in Diabetes Care found some incredible information regarding Diabetes and vision loss.

Science

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Obesity, Diabetes, diabetes and pregnancy, Type 2 Diabetes

Umbilical Cells Shed Light on How Obesity May Pass From Mother to Child

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Researchers at Joslin Diabetes Center now have demonstrated that umbilical cells from children of obese or overweight mothers show impaired expression of key genes regulating cell energy and metabolism, compared to similar cells from babies of non-obese mothers.

Medicine

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Martin Blaser, Nyu Langone, Microbiome, Type 1 Diabetes, Antibiotic, Prenatal, jdrf

Antibiotic Treatment Increased Risk for Type 1 Diabetes in Animal Study

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In doses equivalent to those used regularly in human children, antibiotics changed the mix of gut microbes in young mice to dramatically increase their risk for type 1 diabetes.

Science

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Chemistry/Physics/Materials Science, Medicine/Health (Nutrition/Nutrients, Diet/Body Weight, Cardiology, Metabolism/Metabolic Diseases, Diabetes

Citrus Fruits Could Help Prevent Obesity-Related Heart Disease, Liver Disease, Diabetes

Oranges and other citrus fruits are good for you — they contain plenty of vitamins and substances, such as antioxidants, that can help keep you healthy. Now a group of researchers reports that these fruits also help prevent harmful effects of obesity in mice fed a Western-style, high-fat diet.

Medicine

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Diabetes, Kidney

New Oral Diabetes Drugs May Also Protect Patients’ Kidney Health

• In a clinical trial of patients with type 2 diabetes, canagliflozin (a sodium-glucose cotransporter 2 inhibitor) slowed kidney function decline to a greater extent than glimepiride (a sulfonylurea), while having similar blood sugar–lowering effects.







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