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Science

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Flu Shot, Influenza, Virus, Infectious Disease, Genetics, Interferons, Vaccines

Flu Vaccine Could Get a Much-Needed Boost

More than 700,000 Americans were hospitalized due to illnesses associated with the seasonal flu during the 2014–15 flu season, according to federal estimates. A radical new approach to vaccine development at UCLA may help lower that figure for future flu seasons.

Medicine

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GW School of Medicine and Health Sciences, Baylor College Of Medicine, Schistosomiasis, Infectious Disease, Tropical Medicine, Global Medicine, Parasitology, Parasites, Vaccine, Clinical Trial

Schistosoma Vaccine to Enter Phase Ib Clinical Trial

Researchers at Baylor College of Medicine, in collaboration with a team of researchers at the George Washington University and the René Rachou Institute, have received funding from the National Institutes of Health for a Phase Ib clinical trial for a Schistosomiasis vaccine in an endemic area of Brazil.

Medicine

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Case Western Reserve University School Of Medicine, University Hospitals Cleveland Medical Center, Jonathan Stamler, Enzymes, Cell Function, Nitric Oxide, NO, SNOs, Heart Failure, Cancer, Asthma, Infection, NO synthases, S-nitrosylation, Therapeutic Targets, drug developers, Memory, Molecular Cell

Researchers Discover New Enzymes Central to Cell Function

Doctors have long treated heart attacks, improved asthma symptoms, and cured impotence by increasing levels of a single molecule in the body: nitric oxide. The tiny molecule can change how proteins function. But new research featured in Molecular Cell suggests supplementing nitric oxide—NO—is only the first step. Researchers have discovered previously unknown enzymes in the body that convert NO into “stopgap” molecules—SNOs—that then modulate proteins. The newly discovered enzymes help NO have diverse roles in cells. They may also be prime therapeutic targets to treat a range of diseases.

Medicine

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The Wistar Institute Awarded More Than $1.4 Million to Create a Malaria Vaccine Through Synthetic DNA-Based Technology

Wistar is pleased to announce it has been awarded a $1,494,972 grant by the Bill & Melinda Gates Foundation to advance a DNA-based vaccine candidate for protection against malarial infection utilizing a synthetic DNA platform created in the lab of David B. Weiner, Ph.D., executive vice president, director of the Vaccine & Immunotherapy Center at The Wistar Institute and the W.W. Smith Charitable Trust Professor in Cancer Research.

Medicine

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george washington university school of medicine and health sciences, HIV, Research, T Cell, Microbiology And Immunology, Journal of Clinical Investigation, kick and kill

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 22-Jan-2018 4:00 PM EST

Medicine

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Arthroplasty, Joint Replacement, Infection, next generation sequencing, periprosthetic joint infection, Antibiotics

Novel Method of Isolating Infecting Organisms After Joint Replacement

Next-generation Genomic Sequencing could help identify infecting organisms and guide treatment for patients with joint-replacement infection

Medicine

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HIV, AIDS, CURE, Antibodies, Treatment, Prevention

Multivalent Antibodies Show Effectiveness for HIV Prevention and Promise for Treatment and Cure

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Recent studies testing multivalent combinations of three broadly neutralizing antibodies, or bnAbs, have yielded promising results in animal models of HIV prevention. Two investigators at the University of North Carolina at Chapel Hill describe the potential of bnAbs to inform HIV prevention, treatment and cure strategies in a recent article in the New Journal of Medicine.

Medicine

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Influenza, H3N2, flu, flu and children, Influenza A, Influenza B

Flu Season: How to Stay Healthy

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A Rutgers medical expert explains why this year’s flu season is so fierce and how you can protect yourself

Medicine

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Immunotherapy, Cancer, MD Anderson Cancer Center

National Academy of Sciences Awards Kovalenko Medal to Immunotherapy Pioneer Allison

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Cancer immunotherapy innovator Jim Allison, Ph.D., chair of Immunology at The University of Texas MD Anderson Cancer Center, will receive the 2018 Jessie Stevenson Kovalenko Medal for outstanding research in medical sciences, the National Academy of Sciences announced today.

Medicine

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West Nile Encephalitis, West Nile Virus, Memory

Memory Loss From West Nile Virus May Be Preventable

People who survive brain infection with West Nile virus can have neurological problems long after the virus is gone. A new study in mice suggests that such ongoing problems may be due to unresolved inflammation that hinders the brain's ability to repair damaged neurons and grow new ones. Reducing inflammation with an arthritis drug protected mice from West Nile-induced memory loss.







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