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Diverse Autism Mutations Lead to Different Disease Outcomes

People with autism have a wide range of symptoms, with no two people sharing the exact type and severity of behaviors. Now a large-scale analysis of hundreds of patients and nearly 1000 genes has started to uncover how diversity among traits can be traced to differences in patients’ genetic mutations.

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A reporter's PressPass is required to access this story until the embargo expires on 22-Dec-2014 3:00 PM EST

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A reporter's PressPass is required to access this story until the embargo expires on 24-Dec-2014 12:00 PM EST

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Researchers Discover New Genetic Anomalies in Lung Cancer

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By analyzing the DNA and RNA of lung cancers, researchers at the University of Michigan Comprehensive Cancer Center found that patients whose tumors contained a large number of gene fusions had worse outcomes than patients with fewer gene fusions. In addition, the researchers identified several new genetic anomalies that occur in lung cancer, including in patients with a history of smoking.

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One Common Genetic Variant and the Bacteria Inside Of Us Help Dictate Inflammation, Antitumor Activity, and Outcome in Cancer Patients

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New findings show how an inactivating polymorphism in the TLR5 Gene that occurs in more than one out of 15 people, plays important role in progression of luminal breast cancer and ovarian cancer

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Cells Identified That Enhance Tumor Growth and Suppress Anti-Cancer Immune Attack

A study led by St. Jude Children’s Research Hospital scientists has identified the population of white blood cells that tumors use to enhance growth and suppress the disease-fighting immune system. The results, which appear in the December 18 edition of the scientific journal Immunity, mark a turning point in cancer immunology and provide the foundation for developing more effective immunotherapies.

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Autism and Intellectual Disability Studied in Quest for New Treatment Approaches

NIH-funded collaboration on treatments of rare genetic syndromes that could reveal a shared biology of autism spectrum disorders

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Islet Cell Transplantation Restores Type 1 Diabetics’ Blood Sugar Defense Mechanisms

Type 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments over time are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania, published online in Diabetes.

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‘Sugar-Coated’ Microcapsule Eliminates Toxic Punch of Experimental Anti-Cancer Drug

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Johns Hopkins researchers have developed a sugar-based molecular microcapsule that eliminates the toxicity of an anticancer agent developed a decade ago at Johns Hopkins, called 3-bromopyruvate, or 3BrPA, in studies of mice with implants of human pancreatic cancer tissue. The encapsulated drug packed a potent anticancer punch, stopping the progression of tumors in the mice, but without the usual toxic effects.

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Multiple Allergic Reactions Traced to Single Protein

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Johns Hopkins and University of Alberta researchers have identified a single protein as the root of painful and dangerous allergic reactions to a range of medications and other substances. If a new drug can be found that targets the problematic protein, they say, it could help smooth treatment for patients with conditions ranging from prostate cancer to diabetes to HIV.

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