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Blocking Key Enzyme Halts Parkinson's Disease Symptoms in Mice

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Researchers at Johns Hopkins say they have gleaned two important new clues in the fight against Parkinson’s disease: that blocking an enzyme called c-Abl prevents the disease in specially bred mice, and that a chemical tag on a second protein may signal the disorder’s presence and progression.

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Gene Hunters Find Rare Inherited Mutations Linked to Bipolar Disorder

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Using so-called next-generation genome sequencing, researchers at Johns Hopkins have identified 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder. About 5.6 million Americans are estimated to have bipolar disorder.

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IU Study: Virtual Tissue Technology Reveals New Drug Target in Polycystic Kidney Disease

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Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States. The study, which appears in the journal Molecular Biology of the Cell, reveals that errors in how cells stick together give rise to two forms of kidney cysts.

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Why KID Syndrome Patients Experience Different Sets of Symptoms

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A team of New York-based researchers has compared the effects of two disease-causing mutations, potentially explaining why patients with the rare genetic disorder keratitis-ichthyosis-deafness (KID) syndrome can experience different sets of symptoms. The study, “Syndromic deafness mutations at Asn 14 differentially alter open stability of Cx26 hemichannels,” will be published online June 27 in The Journal of General Physiology.

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NYU’s Bluestone Center Awarded $1.2M from NIH to Investigate Gene Delivery for the Treatment of Oral Cancer Pain

Gene therapy is emerging as an exciting alternative to opioids for the treatment of cancer pain. The NYU researchers seek to alleviate oral cancer pain by reversing epigenetic changes, and using gene therapy, set the stage for a new class of medicines that selectively disrupt nociceptive signaling with fewer off-target effects.

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Heading to the Hospital? Even with Insurance, It May Cost You $1,000 or More, New Study Finds

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Even if you have what you might think of as good health insurance, your next hospital stay could cost you more than $1,000 out of your own pocket. And that amount has gone up sharply in recent years – a rise of more than 37 percent just for straightforward hospital stays for common conditions.

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TSRI Scientists Reveal Single-Neuron Gene Landscape of the Human Brain

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A team of scientists at The Scripps Research Institute (TSRI), University of California, San Diego (UC San Diego) and Illumina, Inc., has completed the first large-scale assessment of single neuronal “transcriptomes.”

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IU Study: 'Smoke Alarm' One of 36 Genes Newly Found to Play Role in Pain Sensation

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Indiana University researchers have that found a suite of genes in both fruit flies and humans -- including one dubbed "smoke alarm" -- plays a role in nerve sensitivity. The study, published June 23 in Cell Reports, could help lead to new drug targets in pain management.

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Novel Study in Nairobi Infants May Accelerate Path to HIV Vaccine

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The first and only study to look at isolate HIV-neutralizing antibodies from infants has found that novel antibodies that could protect against many variants of HIV can be produced relatively quickly after infection compared to adults.

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NYU Research Shows the Struggle to Maintain Accurate Data on the Prevalence of Nonmedical Opioid Use by High School Students

A new study describes the differences in self-reporting of nonmedical opioid use among high school seniors. The results underscore that medical and law enforcement communities may be underestimating opioid use and not just among younger populations.

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Memory Loss Caused by West Nile Virus Explained

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Many West Nile encephalitis survivors suffer long-term neurological problems such as memory loss. New research from Washington University School of Medicine shows that the patients’ own immune systems may have destroyed parts of their neurons, and that intervening in the immune response may help.

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Case Western Reserve University Receives NIH Funding to Participate in Launch of Genomics Center on Alzheimer's Disease

Case Western Reserve University School of Medicine is one of six recipients of a five-year, $10.8 million award from the National Institute on Aging, part of the National Institutes of Health, to establish the Coordinating Center for Genetics and Genomics of Alzheimer’s disease.