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A reporter's PressPass is required to access this story until the embargo expires on 3-Aug-2015 12:00 AM EDT

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New Tool Uses ‘Drug Spillover’ to Match Cancer Patients with Treatments

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Article in journal Bioinformatics from University of Colorado Cancer Center describes a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best “kinase inhibitor” to silence these dangerous genetic causes of disease.

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A reporter's PressPass is required to access this story until the embargo expires on 30-Jul-2015 2:00 PM EDT

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Scripps Florida Scientists Receive $1.4 Million to Study Drug Candidates for Neurological Disorders and Other Diseases

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Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $1.4 million from the National Institute of Mental Health of the National Institutes of Health (NIH) to explore the development of drug candidates for a wide range of conditions, including circadian rhythm disorders.

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Movement Tracking Technology Sheds Light on Different Speech Disorders in Children

Facial motion capture – the same technology used to develop realistic computer graphics in video games and movies – has been used to identify differences between children with childhood apraxia of speech and those with other types of speech disorders, finds a new study by NYU’s Steinhardt School of Culture, Education, and Human Development.

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Researchers Create Promising New Mouse Model for Lung Injury Repair

Researchers at Children’s Hospital Los Angeles and The Saban Research Institute of CHLA created a dynamic functional mouse model for lung injury repair, a tool that will help scientists explain the origins of lung disease and provide a system by which new therapies can be identified and tested.

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University of Colorado Cancer Center and Loxo Oncology Announce Publication That Provides Clinical Validation For LOXO-101 Against TRK Fusion Cancer

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Published today in Cancer Discovery, results of LOXO-101 against TRK fusion cancer confirm that stage IV patient's tumors had substantially regressed. With four months of treatment, additional CT scans demonstrated almost complete disappearance of the largest tumors.

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Researchers Identify Protein in Mice That Helps Prepare for Healthy Egg-Sperm Union

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Researchers at the National Institutes of Health have discovered a protein that plays a vital role in healthy egg-sperm union in mice. The protein RGS2 can delay an egg’s development into an embryo in order to allow time for sperm to arrive and merge with the egg in a healthy fertilization process. The embryo cannot survive without the male chromosomes.

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Wayne State to Lead $4.8 Million NIH Study That Will Teach an Old Drug to Maintain Its Tricks

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With the decline of the development of new antibiotics due to the complexity and expense of discovering them, there has been a rapid growth of antibiotic resistant pathogens that is one of the leading causes of death. With the help of a nearly $4.9 million, 5-year grant from the National Institute for Allergy and Infectious Diseases of the National Institutes of Health, Wayne State University School of Medicine researchers are leading a landmark multi-center, international study that will provide essential information to clinicians for use of polymoxin B in critically ill patients where no other treatments will work.

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Malaria’s Key to the Liver Uncovered

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Scientists uncover a port of liver entry for malaria parasites, and if these results hold up in humans, drugs that target this entry protein might help prevent the spread of disease.