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Cellular Architecture of Human IDH1-Mutant Gliomas Revealed Using Single-Cell RNA Sequencing

Single cell transcriptome analysis in IDH1-mutant gliomas reveals three distinct subpopulations of tumor cells: two dominant populations of specialized glial-like cells and a third rarer stem/progenitor-like subpopulation capable of cellular proliferation.

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Transplanted Nerve Cells Survive a Quarter of a Century in a Parkinson’s Disease Patient

In the late 1980s and over the 1990s, researchers at Lund University in Sweden pioneered the transplantation of new nerve cells into the brains of patients with Parkinson’s disease. The outcomes proved for the first time that transplanted nerve cells can survive and function in the diseased human brain. Some patients showed marked improvement after the transplantation while others showed moderate or no relief of symptoms. A small number of patients suffered unwanted side-effects in the form of involuntary movements.

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Morbidity and Mortality of Meningioma Resection Increases in Octogenarians

This study utilizes a large national database to assess outcomes in octogenarians undergoing surgery for meningioma, as large-scale studies examining the effect outcomes in this group after meningioma surgery had not been conducted.

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Parkinson’s Disease Pathogenesis Is Reduced in a Rat Model Using a Cell-Signaling Inhibitor Drug

Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson’s.

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Changes in Pulsatility and Resistance Indices of Cerebral Arteriovenous Malformation Feeder Arteries After Embolization and Surgery

The authors measured PI, RI in AVM arterial feeders pre- and post-embolization and/or surgery.

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A Trial for Lumbar Drain Placement After Endoscopic Endonasal Skull Base Surgery

Cerebrospinal fluid (CSF) leaks remain a complication after endoscopic endonasal surgery. In this study, subjects were randomized to receive an immediate postoperative lumbar drain or not, with comparison of postoperative leak rates.

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Loyola Promoting National Stroke Awareness Month

In recognition of National Stroke Awareness Month, Loyola Medicine will hold free education-and-screening health fairs, host a mass for stroke survivors and post educational tips on social media in May.

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UT Southwestern Researchers Identify New Autism Blood Biomarker

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Researchers at UT Southwestern Medical Center have identified a blood biomarker that may aid in earlier diagnosis of children with autism spectrum disorder, or ASD.

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Yoga and Aquatic Exercise Can Help Combat MS Symptoms

Exercise can have a positive influence on certain symptoms of multiple sclerosis: Patients who do yoga and aquatic exercise suffer less from fatigue, depression and paresthesia, as reported by researchers from the University of Basel and the Psychiatric University Clinics Basel in a joint study with colleagues in Iran.

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The Incidence of Position-Related Neuropraxia in Patients Undergoing Spine Surgery

The authors reviewed records of patients undergoing spine surgery, with reported incidence of peripheral nerve injury from positioning. IOM changes related to arm and leg positioning and sensitivity and specificity predicting the development of a new position-related peripheral nerve injury was calculated.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 4-May-2016 12:00 PM EDT

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 4-May-2016 4:00 PM EDT

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Act Fast When It Comes to Stroke

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In observance of Stroke Awareness Month, Meridian Neuroscience is kicking off a series of informative community events, providing expert advice, tips, and the latest information about stroke prevention and treatments. The events will take place at Meridian Health locations throughout Monmouth and Ocean counties.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 4-May-2016 2:00 PM EDT

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NIH Funding for Neurosurgeons from 1991-2015

For this study, the authors defined variables associated with neurosurgical NIH funding, the prevalence of funded topics by neurosurgical subspecialty and identified temporal trends in NIH neurosurgical funding by conducting a retrospective review of NIH-funded AANS members.

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Does the Open Payments Database Provide Sunshine on Neurosurgery?

While the OPD details physician interactions with industry, it suffers from multiple inaccuracies and a lack of appropriate context for value transfers.

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The Timing of Cranioplasty: A 10-year Analysis of 754 Patients

When evaluating complication rates against the timing of the cranioplasty, the authors found infection was significantly higher when the cranioplasty was performed 14 days from the original decompression.

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First Structural Views of the NMDA Receptor in Action Will Aid Drug Development

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Structural biologists at Cold Spring Harbor Laboratory (CSHL) and Janelia Research Campus/HHMI, have obtained snapshots of the activation of an important type of brain-cell receptor. Dysfunction of the receptor has been implicated in a range of neurological illnesses, including Alzheimer's disease, Parkinson's disease, depression, seizure, schizophrenia, autism, and injuries related to stroke.

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Neuroscientists Find Evidence for ‘Visual Stereotyping’

The stereotypes we hold can influence our brain’s visual system, prompting us to see others’ faces in ways that conform to these stereotypes, neuroscientists at New York University have found.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 4-May-2016 12:00 PM EDT