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Article ID: 693187

Putting Proteins in Their Proper Place

Perelman School of Medicine at the University of Pennsylvania

A host of nuclear RNA-binding proteins, when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including FTD and ALS. Clumps that form from these disease proteins are composed of sticky fibrils that damage nerve cells.

Released:
19-Apr-2018 4:00 PM EDT
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    19-Apr-2018 4:00 PM EDT

Article ID: 692849

Evidence Shows Non-invasive Nerve Stimulation May Help with Hand Tremor

American Academy of Neurology (AAN)

People with tremors in their hands from a condition called essential tremor may find some relief from a new, non-invasive type of nerve stimulation, according to a preliminary scientific abstract released today that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018.

Released:
15-Apr-2018 11:05 PM EDT
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  • Embargo expired:
    19-Apr-2018 2:00 PM EDT

Article ID: 693015

Defect in Debilitating Neurodegenerative Disease Reversed in Mouse Nerves

Washington University in St. Louis

Scientists have developed a new drug compound that shows promise as a future treatment for Charcot-Marie-Tooth disease, an inherited, often painful neurodegenerative condition that affects nerves in the hands, arms, feet and legs. The researchers used the compound to treat the nerves of mice harboring the genetic defects that cause the disease.

Released:
17-Apr-2018 5:05 PM EDT
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23-Apr-2018 11:00 AM EDT
Released to reporters:
19-Apr-2018 1:05 PM EDT

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  • Embargo expired:
    19-Apr-2018 12:00 PM EDT

Article ID: 692866

Human Protein Important for Cellular Communication Resembles Bacterial Toxin

University of Chicago Medical Center

A protein that plays an important role in embryonic development and nervous system wiring in humans appears to have been borrowed from bacteria. In a new study, scientists from the UChicago and Stanford describe the three-dimensional structure of proteins called teneurins for the first time.

Released:
16-Apr-2018 10:05 AM EDT
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    19-Apr-2018 12:00 PM EDT

Article ID: 692896

Scientists Identify Connection Between Dopamine And Behavior Related To Pain And Fear

University of Maryland School of Medicine

Scientists have for the first time found direct causal links between the neurotransmitter dopamine and avoidance – behavior related to pain and fear. Researchers have long known that dopamine plays a key role in driving behavior related to pleasurable goals, such as food, sex and social interaction. In general, increasing dopamine boosts the drive toward these stimuli. But dopamine’s role in allowing organisms to avoid negative events has remained mysterious.

Released:
16-Apr-2018 1:00 PM EDT
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24-Apr-2018 9:00 AM EDT
Released to reporters:
19-Apr-2018 9:05 AM EDT

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  • Embargo expired:
    18-Apr-2018 4:00 PM EDT

Article ID: 692848

Preliminary Study Suggests Drug May Help Babies with Spinal Muscular Atrophy

American Academy of Neurology (AAN)

A preliminary study suggests that an investigational drug may help increase protein levels in babies with spinal muscular atrophy. The open-label study is released today and will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018.

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15-Apr-2018 11:05 PM EDT
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    18-Apr-2018 4:00 PM EDT

Article ID: 692846

A Single Concussion May Increase Risk of Parkinson’s Disease

American Academy of Neurology (AAN)

People who have been diagnosed with a mild concussion, or mild traumatic brain injury, may have a 56 percent increased risk of developing Parkinson’s disease, according to a study published in the April 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released:
15-Apr-2018 10:05 PM EDT
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Article ID: 693101

Leptin’s Neural Circuit Identified

Tufts University

Scientists identified a neural circuit in the hypothalamus as the primary mechanism mediating the hormone leptin’s anti-obesity and anti-diabetes effects and found two mechanisms underlying leptin’s inhibition of appetite. The work in mice advances efforts to treat human obesity and diabetes.

Released:
18-Apr-2018 3:05 PM EDT
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