Credit: Cincinnati Children’s
This microscopic image shows human lung epithelial cells treated with a new experimental molecular compound called RCM-1. RCM-1 treatment removes a transcription factor called FOXM1 (shown in green) from the nucleus of cells (blue) to the cell cytoplasm. FOXM1 triggers excess inflammation and mucous in diseases like asthma and COPD. Researchers at Cincinnati Children’s report April 18 in Science Signaling that RMC-1 treatment prevents excess inflammation and mucous in mouse models and human respiratory cells.