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“Icebreaker” Protein Opens Genome for T Cell Development, Penn Researchers Find

Researchers describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development. The new connection between TCF-1 and chromatin will aid in...
20-Feb-2018 2:05 PM EST Add to Favorites

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Brain’s Immune System is Key to Recovery from Motor Neuron Degeneration in ALS Animal Model

Researchers engineered mice in which the damage caused by a mutant human TDP-43 protein could be reversed by one type of brain immune cell. TDP-43 is a protein that misfolds and accumulates in the motor areas of the brains of ALS patients. They...
20-Feb-2018 11:05 AM EST Add to Favorites

African Americans with Atrial Fibrillation at Significantly Higher Risk for Stroke Compared to Caucasians with the Disease

African Americans with atrial fibrillation (AF) – a quivering or irregular heartbeat that can lead to a host of dangerous complications – have a significantly higher risk of stroke than Caucasians with the condition, according to new research...
16-Feb-2018 11:00 AM EST Add to Favorites

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Highly Mutated Protein in Skin Cancer Plays Central Role in Skin Cell Renewal

Researchers have shown for the first time that a key protein called KMT2D involved in the epigenetic regulation of gene expression guides this renewal.
19-Feb-2018 11:05 AM EST Add to Favorites

Drug That Treats Psoriasis Also Reduces Aortic Vascular Inflammation

An antibody used to treat the skin disease psoriasis is also effective at reducing aortic inflammation, a key marker of future risk of major cardiovascular events.
15-Feb-2018 12:05 AM EST Add to Favorites

University of Pennsylvania Researchers Conduct Comprehensive Evaluation of Patients with Concussion-Like Symptoms Following Reports of Audible Phenomena in Cuba

A comprehensive evaluation by clinical researchers at the Perelman School of Medicine at the University of Pennsylvania identified a neurological syndrome that left U.S. government personnel serving in Havana, Cuba with persistent memory and...
15-Feb-2018 8:05 AM EST Add to Favorites

Cabozantinib Shows Promise as First Line Treatment for Differentiated Thyroid Cancer

A kinase inhibitor called cabozantinib could be a viable therapy option for patients with metastatic, radioactive iodine-resistant thyroid cancer. In a trial initiated and led by the Abramson Cancer Center and the Perelman School of Medicine at the...
13-Feb-2018 12:05 PM EST Add to Favorites

On-Screen, On-Demand, On-Time: The Future of Telemedicine at Penn Medicine

Penn Medicine Announces its new Center for Connected Care to centralize the health system’s telemedicine activities.
13-Feb-2018 10:05 AM EST Add to Favorites


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