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Progerin’s “Discrimination” May Contribute to Fatal Disease HGPS

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A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology.
5/3/2013 12:00 PM EDT

Wip1 Could Be New Target for Cancer Treatment

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Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers.
5/3/2013 12:00 PM EDT

Entering an Unseen World

A new book presents the in-depth story about the men and women who created a new science, modern cell biology.
2/1/2013 2:00 PM EST

Protein Family Linked to Autism Suppresses the Development of Inhibitory Synapses

Synapse development is promoted by a variety of cell adhesion molecules that connect neurons and organize synaptic proteins. Many of these adhesion molecules are linked to neurodevelopmental disorders; mutations in neuroligin and neurexin proteins,...
1/25/2013 3:00 PM EST

Researchers Use iPSCs to Define Treatment for Heart Disorder

Researchers used induced pluripotent stem cells (iPSCs) derived from a young patient with Long QT syndrome (LQTS), a congenital heart disorder, to determine a course of treatment that helped manage the patient’s life-threatening arrhythmias.
1/11/2013 10:00 AM EST

Surviving Sepsis with LECT2

Failure to launch an adequate immune response may be at the root of septic shock, according to a study published in The Journal of Experimental Medicine on December 17th.
12/12/2012 3:00 PM EST

(Antibody) Orientation Matters

The orientation of antibody binding to bacteria can mean life or death to the bug, according to a study published in The Journal of Experimental Medicine. These findings may help explain why these bacteria cause millions of localized...
12/6/2012 11:00 AM EST

Stay-at-Home Transcription Factor Prevents Neurodegeneration

A JCB study shows how a transcription factor called STAT3 remains in the axon of nerve cells to help prevent neurodegeneration. The findings could pave the way for future drug therapies to slow nerve damage in patients with neurodegenerative...
10/19/2012 1:30 PM EDT

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