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Researchers Reveal a New Pathway Through the Sodium Pump


In addition to its role as a sodium and potassium ion transporter, the ubiquitous sodium pump displays “hybrid” function by simultaneously importing protons into the cell. Proton inflow might play a role in certain pathologies, including heart...
3/25/2014 12:00 PM EDT

p53 Cuts Off Invading Cancer Cells


The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells. Sometimes oncogenes manage to initiate tumor development in the presence of p53, which focuses its efforts instead on limiting the...
3/19/2014 11:00 AM EDT

How Developing Sperm Stick to the Right Path


The process of producing high-quality, fertile sperm requires many steps. Researchers show the transcription factor p73 promotes this process by regulating the adhesions between developing sperm and their support cells.
3/19/2014 11:00 AM EDT

Gut Microbes Spur Development of Bowel Cancer


It is not only genetics that predispose to bowel cancer; microbes living in the gut help drive the development of intestinal tumors, according to new research in mice.
2/25/2014 3:00 PM EST

Mdm2 Suppresses Tumors by Pulling the Plug on Glycolysis


Cancer cells have long been known to have higher rates of the energy-generating metabolic pathway known as glycolysis. This enhanced glycolysis is thought to allow cancer cells to survive the oxygen-deficient conditions they experience in the center...
2/19/2014 1:00 PM EST

Two-Pronged Approach Successfully Targets DNA Synthesis in Leukemic Cells


Researchers show that a novel two-pronged strategy targeting DNA synthesis can treat leukemia in mice while sparing damage to normal blood cells.
2/19/2014 2:00 PM EST

A Trigger for Muscular Diseases


Various muscular diseases are associated with changes in the elasticity of the protein titin, but whether these changes are a cause or an effect of disease has been unclear. Researchers help solve this “chicken or the egg” conundrum and identify...
1/22/2014 2:15 PM EST

Unexpected Player in Regulation of Blood Cholesterol Levels


Kinesins are motor proteins that “walk” along microtubules and transport various cargoes throughout the cell. Researchers uncover an unexpected role for one kinesin in the pathway that regulates cholesterol levels in the blood.
1/22/2014 2:00 PM EST

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