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A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities

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A new original research article in SLAS Discovery presents a fast, sensitive, and robust methodology for screening small molecule inhibitors against CD73/Ecto-5’-Nucleotidase, a promising target for developing anti-cancer drugs.
11-Jan-2018 7:05 AM EST Add to Favorites

A Fluorescence-Based High-Throughput Assay for the Identification of Anticancer Reagents Targeting Fructose-1,6-Bisphosphate Aldolase

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An original research report by Eun Jeong Cho et al. (University of Texas at Austin) in the January 2018 Issue of SLAS Discovery presents a newly designed biochemical assay that is rapid, sensitive, inexpensive, and high-throughput screening...
21-Dec-2017 9:05 AM EST Add to Favorites

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of Cytochrome CYP1A2 Inhibitors in Metabolic Mixtures

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This new (and freely available) original research article presents a fast, robust and accurate methodology for correlating compound identity to CYP1A2 potency of inhibitors in metabolic mixtures. The methodology is centered around an at-line...
19-Dec-2017 7:05 AM EST Add to Favorites

Bioluminescent Succinate Detection for Monitoring the Activity of Dioxygenases and JMJC Demethylases

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A new (and freely available) original research article published ahead-of-print at SLAS Discovery Online describes a new methodology that enables the investigation of a large number of structurally conserved enzymes belonging to the...
12-Dec-2017 3:05 AM EST Add to Favorites

Advances in MALDI Mass Spectrometry within Drug Discovery

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SLAS Discovery marks the 30th anniversary of Matrix Assisted Laser Desorption/Ionization Time of Flight (MALDI TOF), the soft ionization technique for analyzing non-volatile biomolecules using mass spectrometry, with a special issue showcasing 10...
28-Nov-2017 7:05 AM EST Add to Favorites

Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing

A review article in the December 2017 issue of SLAS Technology provides important information for life sciences and technology professionals in academia and industry and members of the general public who are interested in antibiotic resistance,...
22-Nov-2017 6:05 AM EST Add to Favorites

Theranostic Nanoparticles for Tracking and Monitoring Disease State

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A new SLAS Technology review article by researchers at the University of Southern California and the University of California, Los Angeles, sheds light on the growing number and more sophisticated designs of theranostic nanoparticles.
6-Nov-2017 9:05 AM EST Add to Favorites

In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization

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A new SLAS Discovery article available for free ahead-of-print enables researchers to derive more clinically-relevant information from 3D cell culture models.
1-Nov-2017 3:05 AM EDT Add to Favorites

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