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Finding the Target: How Timing Is Critical in Establishing an Olfactory Wiring Map

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In the April 11, 2014 issue of Science, Associate Investigator C. Ron Yu, Ph.D. and colleagues at the Stowers Institute of Medical Research identify a developmental window during which olfactory neurons of newborn mice can form a proper wiring map....
4/3/2014 9:30 AM EDT

Planaria Deploy an Ancient Gene Expression Program in the Course of Organ Regeneration

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In the April 15, 2014 issue of the online journal eLife, Stowers Institute for Medical Research Investigator Alejandro Sánchez Alvarado and colleagues report the identification of genes that worms use to rebuild an amputated pharynx.
4/10/2014 11:00 AM EDT

Going Global

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In textbooks, the grand-finale of cell division is the tug-of-war fought inside dividing cells as duplicated pairs of chromosomes get dragged in opposite directions into daughter cells. This process, called mitosis, is visually stunning to observe...
4/2/2014 4:00 PM EDT

Could Far-Flung Mutations in the Genome Activate Cancer-Causing Genes? Ask an Expert!

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A Perspective published with his postdocs, Hans-Martin Herz, Ph.D. and Deqing Hu, Ph.D., in the March 20th issue of Molecular Cell, will serve as the basis for Shilatifard’s AACR talk. In it, they summarize how aberrant enhancer...
3/14/2014 5:00 PM EDT

What Makes Memories Last?

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Prions can be notoriously destructive, spurring proteins to misfold and interfere with cellular function as they spread without control. New research, published in the open access journal PLOS Biology on February 11 2014, from scientists at...
2/4/2014 10:00 AM EST

Conserved Nuclear Envelope Protein Uses a Shuttle Service to Travel Between Job Sites

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Researchers at the Stowers Institute for Medical Research have glimpsed two proteins working together inside living cells to facilitate communication between the cell's nucleus and its exterior compartment, the cytoplasm. The research provides new...
2/5/2014 5:00 PM EST

Fruit Flies Reveal Normal Function of a Gene Mutated in Spinocerebellar Ataxia Type 7

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Disruptive clumps of mutated protein are often blamed for clogging cells and interfering with brain function in patients with the neurodegenerative diseases known as spinocerebellar ataxias. But a new study in fruit flies suggests that for at least...
1/24/2014 11:00 AM EST

Next-Gen Reappraisal of Interactions Within a Cancer-Associated Protein Complex

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At a glance, DNA is a rather simple sequence of A, G, C, T bases, but once it is packaged by histone proteins into an amalgam called chromatin, a more complex picture emerges. Histones, which come in four subtypes—H2A, H2B, H3, and H4—can either...
1/15/2014 3:00 PM EST

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