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Dividing T Cells Inherit Uneven Enzyme Activity: A Potential Target for Improving Cancer Immunotherapy

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When an immune T cell divides into two daughter cells, the activity of an enzyme called mTORC1, which controls protein production, splits unevenly between the progeny, producing two cells with different properties. Such "asymmetric division,"...
1-Jul-2016 10:45 AM EDT Add to Favorites

Rx for Better Orthopaedic Surgeons: Track Their Errors as Well as Their Skills

In a small study to determine the best way to assess the operating skills of would-be orthopaedic surgeons, researchers found that tracking the trainees’ performance on cadavers using step-by-step checklists and measures of general surgical...
29-Jun-2016 12:05 PM EDT Add to Favorites

Researchers Identify the Molecular Roots of Lung Damage in Preemies with GI Disease

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Johns Hopkins researchers report they have figured out a root cause of the lung damage that occurs in up to 10 percent of premature infants who develop necrotizing enterocolitis, a disorder that damages and kills the lining of the intestine.
29-Jun-2016 12:05 PM EDT Add to Favorites

Ovarian Cancer Study Uncovers New Biology

In what is believed to be the largest study of its kind, scientists at The Johns Hopkins University and the Pacific Northwest National Laboratory led a study that examined the proteomes of 169 ovarian cancer patients to identify critical proteins...
23-Jun-2016 12:00 PM EDT Add to Favorites

Normal Bacterial Colonies in Human Body Linked to Presence of Cancer of the Mouth and Throat

In a sample study, researchers at Johns Hopkins say they have found an association between the makeup of an individual’s microbiome and head and neck cancer, a finding that potentially advances the quest for faster and more accurate cancer...
27-Jun-2016 5:05 PM EDT Add to Favorites

Blocking Key Enzyme Halts Parkinson's Disease Symptoms in Mice

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Researchers at Johns Hopkins say they have gleaned two important new clues in the fight against Parkinson’s disease: that blocking an enzyme called c-Abl prevents the disease in specially bred mice, and that a chemical tag on a second protein may...
22-Jun-2016 10:05 AM EDT Add to Favorites

Teaching an Old Drug New Tricks to Fight Cytomegalovirus

Researchers at Johns Hopkins have found that an old drug once mostly used to treat amebiasis — a disease caused by a parasite — and induce vomiting in cases of poisoning appears to also halt replication of cytomegalovirus (CMV), a herpesvirus...
27-Jun-2016 2:05 PM EDT Add to Favorites

Gene Hunters Find Rare Inherited Mutations Linked to Bipolar Disorder

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Using so-called next-generation genome sequencing, researchers at Johns Hopkins have identified 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder. About 5.6 million Americans are estimated to have...
27-Jun-2016 1:35 PM EDT Add to Favorites

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