La Jolla Institute for Allergy and Immunology
La Jolla, CA USA
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T Cells Join the Fight Against Zika


The worst of the global Zika virus outbreak may be over but many key questions remain, such as why the virus persists in certain tissues after the systemic infection has cleared; how does the immune system counteract the virus and protect against...
12-Jan-2017 9:05 AM EST Add to Favorites

LJI Researchers Strengthen the Case for Sexual Transmission of Zika Virus


Aedes aegypti mosquitoes harboring parasitic Zika virus (ZIKV) are the primary transmitters of virus to humans, potentially causing catastrophic congenital microcephaly in babies born to women bitten by infected mosquitoes. But confirmation earlier...
15-Dec-2016 9:40 AM EST Add to Favorites

Exhausted T cells


In a bid to better understand the gene expression patterns that control T cell activity, researchers at the La Jolla Institute for Allergy and Immunology mapped genome-wide changes in chromatin accessibility as T cells respond to acute and chronic...
19-Dec-2016 1:05 PM EST Add to Favorites

Dual Loss of TET Proteins Prompts Lethal Upsurge in Inflammatory T Cells in a Mouse Model of Lymphoid Cancer


Members of the TET family of proteins help protect against cancer by regulating the chemical state of DNA —and thus turning growth-promoting genes on or off. The latest findings reported by researchers at La Jolla Institute for Allergy and...
12-Dec-2016 9:05 AM EST Add to Favorites

TET Proteins Drive Early Neurogenesis

The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells’ offspring have found their station and purpose in the body. Their decisions are guided in part by TET proteins rewriting...
7-Dec-2016 10:40 AM EST Add to Favorites

LJI Scientists Flip Molecular Switches to Distinguish Closely Related Immune Cell Populations


The cornerstone of genetics is the loss-of-function experiment. In short, this means that to figure out what exactly gene X is doing in a tissue of interest—be it developing brain cells or a pancreatic tumor—you somehow cut out, switch off or...
27-Oct-2016 12:35 PM EDT Add to Favorites

ZikaPLAN: La Jolla Institute Unites with 25 Research Organizations to Fight Zika Virus and Build Long-Term Outbreak Response Capacity in Latin America


La Jolla Institute for Allergy and Immunology (LJI) is among the 25 leading research and public health organizations from Latin America, North America, Africa, Asia, and Europe gathered in Recife for the launch of ZikaPLAN (Zika Preparedness Latin...
26-Oct-2016 12:35 PM EDT Add to Favorites

Zika Infection May Affect Adult Brain Cells, Suggesting Risk May Not Be Limited to Pregnant Women


Concerns over the Zika virus have focused on pregnant women due to mounting evidence that it causes brain abnormalities in developing fetuses. However, new research in mice from scientists at The Rockefeller University and La Jolla Institute for...
24-Oct-2016 11:20 AM EDT Add to Favorites

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