La Jolla Institute for Allergy and Immunology
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The Molecular Underpinnings of T Cell Exhaustion

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One reason we survive into adulthood is that cell-killing T cells usually recognize and eliminate cancerous or pathogen-infected cells. But prolonged overactivity of immune cells summoned to a tumor or infection site can render them useless to...
14-Mar-2017 10:20 AM EDT Add to Favorites

Pre-Existing Immunity to Dengue Virus Shapes Zika-Specific T Cell Response

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Although Zika and dengue are considered different virus “species,” they are so closely related that the immune system treats Zika just like another version of dengue, report researchers at La Jolla Institute for Allergy and Immunology. Their...
10-Mar-2017 4:15 PM EST Add to Favorites

T Cells Join the Fight Against Zika

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The worst of the global Zika virus outbreak may be over but many key questions remain, such as why the virus persists in certain tissues after the systemic infection has cleared; how does the immune system counteract the virus and protect against...
12-Jan-2017 9:05 AM EST Add to Favorites

LJI Researchers Strengthen the Case for Sexual Transmission of Zika Virus

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Aedes aegypti mosquitoes harboring parasitic Zika virus (ZIKV) are the primary transmitters of virus to humans, potentially causing catastrophic congenital microcephaly in babies born to women bitten by infected mosquitoes. But confirmation earlier...
15-Dec-2016 9:40 AM EST Add to Favorites

Exhausted T cells

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In a bid to better understand the gene expression patterns that control T cell activity, researchers at the La Jolla Institute for Allergy and Immunology mapped genome-wide changes in chromatin accessibility as T cells respond to acute and chronic...
19-Dec-2016 1:05 PM EST Add to Favorites

Dual Loss of TET Proteins Prompts Lethal Upsurge in Inflammatory T Cells in a Mouse Model of Lymphoid Cancer

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Members of the TET family of proteins help protect against cancer by regulating the chemical state of DNA —and thus turning growth-promoting genes on or off. The latest findings reported by researchers at La Jolla Institute for Allergy and...
12-Dec-2016 9:05 AM EST Add to Favorites

TET Proteins Drive Early Neurogenesis

The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells’ offspring have found their station and purpose in the body. Their decisions are guided in part by TET proteins rewriting...
7-Dec-2016 10:40 AM EST Add to Favorites

LJI Scientists Flip Molecular Switches to Distinguish Closely Related Immune Cell Populations

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The cornerstone of genetics is the loss-of-function experiment. In short, this means that to figure out what exactly gene X is doing in a tissue of interest—be it developing brain cells or a pancreatic tumor—you somehow cut out, switch off or...
27-Oct-2016 12:35 PM EDT Add to Favorites

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