Mechanism of Icariin regulation of the effect of miR-122-5p in osteoblast-derived exosomes on osteogenesis and migration of bone marrow mesenchymal stem cells
PreprintsAofei Yang, z刘 lx, Lu Yang, Haijia Xu, Jing Hu, Hantao Cai, Yu Ning, Zhanghua Li
Aofei Yang, z刘 lx, Lu Yang, Haijia Xu, Jing Hu, Hantao Cai, Yu Ning, Zhanghua Li
Shiwei Chen, Taiyong Wu, Simin Ning, Zhuangzhuang Wu, Wenxuan Jin, Pengcui Li
Jeong Uk Lim, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chin Kook Rhee
Hosuk Ryou, Korsuk Sirinukunwattana, Alan Aberdeen, Gillian Grindstaff, Bernadett Stolz, Helen Byrne, Heather A. Harrington, Nikolaos Sousos, Anna L. Godfrey, Claire N. Harrison, Bethan Psaila, Adam J. Mead, Gabrielle Rees, Gareth D.H. Turner, Jens Rittscher, Daniel Royston
Guoqing Wang, Xiangpeng Shen, Xiangkong Song, Ningfen Wang, Xuewen Wo, Yonglei Gao
Researchers have created an injectable therapy for spinal cord injuries that uses specially engineered molecules that trigger a healing response in spinal cells. These molecules come together to form tiny fibers in a liquid solution. Scientists can control the motion of these fibers, allowing the fibers to connect more effectively with cells in the spine. The research may lead to a cure for spinal injuries in humans.
Shigeki Yoshiura, Fumio Matsuzaki
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Han Sun, Antje K Rottner, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Weslowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders Larsson, Patrick E MacDonald, Benjamin Davies, Marcel Den Hoed, Anna L Gloyn
Mahdi Moqri, Andrea Cipriano, Daniel Nachun, Tara Murty, Guilherme De Sena Brandine, Sajede Rasouli, Andrei Tarkhov, Karolina A Aberg, Edwin Jcg Van Den Oord, Wanding Zhou, Andrew D Smith, Crystal Mackall, Vadim N Gladyshev, Steve Horvath, Michael Snyder, Vittorio Sebastiano
Yue Wu, Bibo Zhu, Ruixuan Zhang, Nick P. Goplen, Xiaochen Gao, Harish Narasimhan, Ao Shi, Yin Chen, Ying Li, Haidong Dong, Thomas J. Braciale, Jie Sun
Jacqueline A Larouche, Emily C Wallace, Bonnie D Spence, Scott A Johnson, Mangesh Kulkarni, Eric Buras, Bryan N Brown, Stephen F Badylak, Carlos Andres Aguilar
Your chance of breaking a bone sometime within the next year is nearly 4%. If you're unlucky enough to need a bone replacement, it'll probably be based on a metal part. Unfortunately, metal parts are sometimes toxic over time, and will not help your original bone regrow.
Aqueous droplet formation by liquid-liquid phase separation (or coacervation) in macromolecules is a hot topic in life sciences research.
Osteoarthritis – a painful condition that results from the deterioration of the cartilage in our joints – affects millions of people worldwide. To combat this issue, NIBIB-funded researchers are developing an implantable, biodegradable film that helps to regenerate the native cartilage at the site of damage. Their study, performed in rabbits, could be an initial, important step in the establishment of a new treatment for this common condition.
Austin B. Keeler, Amy L. Van Deusen, Irene Cheng, Corey M. Williams, Sarah M. Goggin, Ashley K. Hirt, Shayla A. Vradenburgh, Kristen I. Fread, Emily A. Puleo, Lucy Jin, O. Yipkin Calhan, Christopher D Deppmann, Eli R. Zunder
Jiawei Zhao, Yuemeng Jia, Dilnar Mahmut, Amy Anderson Deik, Sarah Jeanfavre, Clary B. Clish, Vijay G. Sankaran
Yoshihiro Yamanaka, Kumiko Yoshioka-Kobayashi, Sofiane Hamidi, Sirajam Munira, Kazunori Sunadome, Yi Zhang, Yuzuru Kurokawa, Ai Mieda, Jamie L. Thompson, Janet Kerwin, Steven Lisgo, Takuya Yamamoto, Naomi Moris, Alfonso Martinez-Arias, Taro Tsujimura, Cantas Alev
Roberto Altieri, Giuseppe Broggi, Francesco Certo, Daniela Pacella, Giacomo Cammarata, Massimiliano Maione, Marco Garozzo, Davide Barbagallo, Michele Purrello, Rosario Caltabiano, Gaetano Magro, Giuseppe Barbagallo
Pierre-Antoine Defossez, Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, Fumihito Miura, Laure Ferry, Olivier Kirsh, Anaelle Azogui, Kohsuke Yamaguchi, Marthe Laisné, Cécilia Domrane, Frédéric Bonhomme, Arpita Sarkar, Marine Delagrange, Bertrand Ducos, Gael Cristofari, Takashi Ito, Maxim Greenberg
Unedo Hence Markus Sihombing, Andrijono Andrijono, Gatot Purwoto, Supriadi Gandamihardja, Alida R. Harahap, Primariadewi Rustamadji, Aria Kekalih, Retno Widyawati, Dzicky Rifqi Fuady
Miguel Branco, Jennifer Frost, Samuele Amante, Hiroaki Okae, Eleri Jones, Brogan Ashley, Rohan Lewis, Jane Cleal, Takahiro Arima, Tania Maffucci, Matthew Caley
Emiliano Hergenreder, Yana Zorina, Zeping Zhao, Hermany Munguba, Elizabeth L Calder, Arianna Baggiolini, Andrew P Minotti, Ryan M Walsh, Conor Liston, Joshua Levitz, Ralph Garippa, Shuibing Chen, Gabriele Ciceri, Lorenz Studer
Gabriele Ciceri, Hyunwoo Cho, Meghana Kshirsagar, Arianna Baggiolini, Kelly A Aromolaran, Ryan M Walsh, Peter A Goldstein, Richard P Koche, Christina S Leslie, Lorenz Studer
Takashi Satake, Shingo Komura, Hitomi Aoki, Akihiro Hirakawa, Yuuki Imai, Haruhiko Akiyama
Xiangfei Yuan, Yang Lu, Yuanyuan Yang, Wencong Tian, Dongmei Fan, Ruoqi Liu, Xiaomin Lei, Yafei Xia, Lei Yang, Shu Yan, Dongsheng Xiong
Smitha Surendran Thamarath, Ching Ann Tee, Shu Hui Neo, Dahou Yang, Rashida Binte Othman, Laurie Boyer, Jongyoon Han
Ula Jurkunas, Jia Yin, Lynette Johns, Sanming Li, Helene Negre, Kit Shaw, Lassana Samarakoon, Allison Ayala, Ahmad Kheirkhah, Kishore Katikireddy, Alex Gauthier, Stephan Ong Tone, Stacey Ellender, Diego Hernandez Rodriguez, Heather Daley, Reza Dana, Jerome Ritz, Myriam Armant
Wei Wang, Lingjuan Zhao, Yong Sun, Weicong Ren, Xuxia Zhang, Chuanyou Li, Mengqiu Gao
Karthikeyan Kandasamy, Nuryanti Binti Johana, Lay Geok Tan, Yvonne Tan, Julie Yeo Su Li, Li Zhihui, Koh Jiayu, Florent Ginhoux, Jerry Ky Chan, Mahesh A Choolani, Citra Nz Mattar
The Liver4Life research team owes its perfusion machine, which was developed in house, to the fact that it became possible to implant a human organ into a patient after a storage period of three days outside a body.
An innovative artificial enzyme has shown it can chew through woody lignin, an abundant carbon-based substance that stores tremendous potential for renewable energy and materials.
Blake T Darkow, Joseph P Herbert, Mark J Messler, Abigail Grisolano, August J Hemmerla, Austin D Kimes, Julien Lanza, Yisheng Sun, Julia R Crim, Derek Stensby, Caixia Wan, Don K Moore, Bret D Ulery
Amala John, Elizabeth Sarkel Smith, Daniel S Jones, Cara Soyars, Zachary L. Nimchuk
Shandong Tao, Lixiao Song, Dan Zhou, Banghe Ding, Yuan Deng, Yue Chen, Zhengmei He, Chunling Wang, Liang Yu
Gabi Escherich, Kerstin Mezger, Sabine Ebert, Hannah Muhle, Udo Zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Tobias Feuchtinger, Thomas Imschweiler, Norbert Jorch, Arnulf Pekrun, Irene Schmid, Franziska Schramm, Martin Zimmermann, Martin Horstmann
Luis Quintanilla, Juan Song, Jeremy Simon, Ya-Dong Li, Brent Asrican, Seth Tart, Yan-Jia Luo, Yijing Su, Hongjun Song, Ryan N. Sheehy, Guo-Li Ming
Dongshu Liu, Suhe Dong, Cong Liu, Jicong Du, SiNian Wang, Huijie Yu, Wei Li, Zhongmin Chen, Renjun Peng, Qisheng Jiang, Mengying Zou, Fengsheng Li, Rong Zhang
Pronamee Borah, Nitin Dayal, Sangeeta Pathak, Rahul Naithani
Xiaohong Zhao, Xue Li, Ying Wang, Yicheng Guo, Yong Huang, Dalun Lv, Mingxing Lei, Shicang Yu, Gaoxing Luo, Rixing Zhan
Alec B Chaves, Donghai Zheng, Jonathan A Johnson, Bryan C Bergman, Zachary W Patinkin, Vincent Zaegel, Ericka M Biagioni, Polina Krassovskaia, Nicholas T Broskey, Linda E May, Dana Dabelea, Joseph A Houmard, Kristen E Boyle
Xinyang Li, Zhenyu Xie, Yinde Huang, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Wenbin Chen, Yuchen He, Jian Zhang
Old dogs may not learn new tricks, but old drugs can, according to a research team based in China.
Poor healing of cutaneous wounds is a common medical problem in the field of traumatology. Due to the intricate pathophysiological processes of wound healing, the use of conventional treatment methods, such as chemical molecule drugs and tradit
BACKGROUNDDiabetes mellitus (DM) is a serious and growing global health burden. It is estimated that 80% of diabetic patients have micturition problems such as poor emptying, urinary incontinence, urgency, and urgency incontinence. Patients wit
BACKGROUNDHuman Wharton’s jelly-derived mesenchymal stromal/stem cells (hWJ-MSCs) have gained considerable attention in their applications in cell-based therapy due to several advantages offered by them. Recently, we reported that hWJ-MSCs an
Pharmacological inhibitors of glutathione synthesis and circulation, such as buthionine-sulfoximine, inhibit glutathione metabolism. These drugs decrease the aggressiveness of pancreatic cancer, inhibit tumor stem cell survival, and reduce chem
Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.
Prilenia Therapeutics B.V., a clinical stage biotechnology company focused on the urgent mission to develop novel therapeutics to slow the progression of neurodegenerative and neurodevelopmental disorders, today announced publication of its research in the peer-reviewed journal Autophagy which support pridopidine’s potential neuroprotective properties by enhancing autophagy in an amyotrophic lateral sclerosis (ALS) model.
A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response.