UC San Diego biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new “gene atlas” with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Scientists with Cedars-Sinai Guerin Children’s, the University of California, San Francisco (UCSF), and other institutions have identified the critical first steps in how the digestive system develops.
Rutgers Health researchers found that long COVID is associated with active inflammatory changes in the nervous system, but the condition is distinct from Alzheimer’s disease and other neurodegenerative disorders.
Researchers from Johns Hopkins Medicine say they have uncovered insights as to why lupus symptoms and severity present differently in individuals with the autoimmune condition, which affects up to 1.5 million Americans.
A new study led by University of Michigan Health Rogel Cancer Center researchers identifies novel biomarkers in renal cell carcinomas.
• Two complementary research articles, published simultaneously in the journals Science and Cell Stem Cell by a team of scientists from the UPF and IRB Barcelona, reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles. • The coordination between the two clocks (central and peripheral) guarantees 50% of the circadian functions of tissues, including vital processes such as the cell cycle, DNA repair, mitochondrial activity, and metabolism. • Synchronisation between the central brain clock and peripheral ones prevents premature muscle ageing and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.
Researchers have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance of the hypothalamus of the brain and its role in common childhood obesity and the target gene may serve as a druggable target for future therapeutic interventions.
By examining which genes were turned on and off in a mix of cell types from breast cancer biopsies, a team led by UT Southwestern Medical Center researchers developed a tool that can accurately predict which patients with breast cancer will respond to immunotherapies.
Fungal disease Fusarium head blight (FHB) is on the rise due to increasingly humid conditions induced by climate change during the wheat growing season, but a fundamental discovery by University of Adelaide researchers could help reduce its economic harm.
Scientists from the University of California San Diego discovered a novel signaling pathway in liver cells, leading to a treatment for fibrosis.
Conditions such as diabetes, heart attack and vascular diseases commonly diagnosed in people with spinal cord injuries can be traced to abnormal post-injury neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs, a new animal study has found.
Using state-of-the-art microscopy techniques developed on campus, researchers at UC San Diego School of Medicine have shed new light on the underlying mechanisms driving Alzheimer’s disease.
A new study offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson’s disease and some dementias.
The Martinot Lab at Cummings School of Veterinary Medicine at Tufts University, where faculty and students have been researching the mpox virus in endometrial tissues to raise awareness of the potential increased risk of mpox virus for women.
Biologist B. Duygu Özpolat at Washington University in St. Louis and colleagues published a single-cell atlas for a highly regenerative annelid worm. This research may help inform stem cell technologies and regenerative medicine down the line.
The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That’s still the case, for the most part, but, Johns Hopkins Medicine researchers, studying nerve cells grown in the lab and mice, say that the proteasome’s role may go well beyond that.
A research team from the National University of Singapore (NUS) has unearthed new findings which may help explain the connection between cancer risk and poor diet, as well as common diseases like diabetes, which arise from poor diet.
In findings published in Cell Reports, senior author Jerold Chun, M.D., Ph.D., and team also discovered that the biological instructions within these vesicles differed significantly in postmortem brain samples donated from patients suffering from Alzheimer’s disease.
A research team led by the University of California, Irvine has built the first genetic reference maps for short lengths of DNA repeated multiple times which are known to cause more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington’s disease and multiple cancers.
New research from the University of Wisconsin–Madison decodes the evolutionary pathway of regulatory proteins, the molecules that help control gene expression.The findings from the Raman Lab in the Department of Biochemistry recently published their findings in the journal Cell Systems.
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