Feature Channels: Clinical Trials

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An individual patient data (IPD) meta-analysis of randomized, controlled clinical trials provides strong evidence for the addition of androgen deprivation therapy (ADT) to definitive radiotherapy (RT) for the treatment of prostate cancer, with the projection that adding ADT to the treatment of 10-15 men would prevent the development of distant metastasis in one man.

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Researchers at University of California San Diego School of Medicine tested the same treatment for kids with Kawasaki disease and rare COVID-19 reaction.

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Cleveland Clinic researchers have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

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ISPOR—The Professional Society for Health Economics and Outcomes Research announced today that the Real-World Evidence Transparency Initiative has launched the Real-World Evidence Registry.

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Using fewer—but higher—doses of radiation to treat men with prostate cancer who had their prostates removed does not increase long-term side effects or lower their quality of life compared to conventional radiation treatment, a new, multi-institutional clinical trial shows.

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A new trial by UC San Diego Health infectious disease specialist Maile Young Karris, MD, will use longitudinal questionnaires and qualitative interviews to assess the impact of living in an interconnected virtual village on the loneliness known to afflict older people with HIV.

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Expanded partnerships, access to clinical trials and new medical and behavioral treatments and interventions reaching individuals more quickly will benefit communities in Pennsylvania and beyond thanks to the renewal of Penn State’s Clinical and Translational Science Award (CTSA) funded by the National Institutes of Health (NIH).

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Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.

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University of Illinois Chicago researchers are launching a clinical trial that focuses on diet quality and its effect on asthma in adults.The study — Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern — aims to evaluate if and how a healthy diet can improve asthma.

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A new study shows that women are underrepresented in stroke clinical trials relative to the number who have strokes in the general population. The research is published in the October 13, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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USC Norris Comprehensive Cancer Center launches global clinical trial testing potential therapy for aggressive type of breast cancer.

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Early data from a biomarker-driven Phase I trial of ATR inhibitor RP-3500 shows encouraging results for patients with advanced solid tumors harboring selected molecular alterations

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Newly developed device shows the potential to automate the critical task of detecting IV infiltration

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The American Society for Radiation Oncology (ASTRO) announced the press program for the 2021 ASTRO Annual Meeting. Researchers will discuss their findings in three news briefings on October 25 and 26 in Chicago and via live webcast. Reporters can register for press access at www.astro.org/annualmeetingpress.

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Researchers from Argonne and the University of Chicago have found that lasofoxifene, a drug used to treat osteoporosis, may be a safer and more effective treatment for breast cancer than the current gold standard. Clinical trials have begun.

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Researchers have received a $5.3 million grant to conduct the Eliminating Monitor Overuse (EMO) clinical trial, seeking to discover how best to reduce the overuse of unnecessary monitoring strategies for infants who have a common lung infection called bronchiolitis.

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Promising Therapy Is Offered through Multicenter International Study

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The American Thoracic Society strongly opposes the use of Ivermectin for the prevention and treatment of COVID-19 outside of a registered clinical trial. The ATS further opposes court or other legal efforts to compel physicians to provide unproven treatments for COVID-19 or any other health condition.

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CRI's Online Immunotherapy Patient Summit connects cancer patients and caregivers to scientific and medical experts, explores clinical trials, cancer care disparities

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A clinical trial investigating whether high-dose vitamin D3 supplements combined with a multivitamin could effectively prevent cluster headaches is now recruiting patients at The University of Texas Health Science Center at Houston (UTHealth Houston).

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A University of Miami Miller School of Medicine urologist was awarded a significant R01 grant from the National Institutes of Health (NIH) for a first-of-its-kind study for treating erectile dysfunction using a combination of platelet-rich plasma and shockwave therapy.

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New research from Johns Hopkins Kimmel Cancer Center investigators shows why some drugs in clinical trials for treating a form of acute myeloid leukemia (AML) often fail and demonstrates a way to restore their effectiveness.

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The National Cancer Institute renewed the “comprehensive” designation of the UC Davis Comprehensive Cancer Center in recognition of its breadth and depth in cancer research, clinical care, cancer control and population sciences.

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New research in JNCCN finds four out of five cancer therapies tested in Phase III trials do not achieve clinically-meaningful benefit in prolonging survival, and is the first study to quantify the number of false-positive, false-negative, and true-negative trial results.

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The outlook for patients diagnosed with breast cancer has been changing for the better over time thanks to surgical advances, clinical trials & a more personalized treatment approach. Dr. Lindsay Potdevin, surgical oncologist at Rutgers Cancer Institute of New Jersey, shares how these advances are improving the lives of patients.

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Early results from a UCLA-led clinical trial found treating women with estrogen receptor (ER)-positive and human epidermal growth factor receptor-2 (HER2)-negative early breast cancers with a novel type of anti-hormonal therapy, called an oral selective estrogen receptor degrader (SERD), led to clinically meaningful reductions in tumor activity prior to surgery.

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More than half of patients with non-small cell lung cancer (NSCLC) bearing a mutation in the HER2 gene had their tumors stop growing or shrink for an extended time after treatment with a drug that hitches a chemotherapy agent to a highly targeted antibody, an international clinical trial led by investigators at Dana-Farber Cancer Institute has found.

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Moffitt Cancer Center is participating in a national pilot project being conducted by the American Society of Clinical Oncology (ASCO) and the Association of Community Cancer Centers (ACCC). The pilot project is testing a research site self-assessment tool and an implicit bias training program focused on increasing racial and ethnic diversity among cancer treatment trial participants.

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Rutgers pioneers a virtual approach to clinical trials, revolutionizing how studies are performed and increasing participant access, leading to stronger scientific results and accelerated treatment

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Modest weight loss can lead to meaningful risk reduction in adults with obesity. Although both behavioral economic incentives and environmental change strategies have shown promise for initial weight loss, to date their efficacy alone or in combination have not been compared.

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Eating yogurt containing a particular strain of a well-studied probiotic appears to protect against harmful changes in the gut microbiome that are associated with antibiotic administration.

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In a research letter in JAMA, physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) found that the vast majority of patients who had a diagnosis of either cognitive impairment, Alzheimer’s disease, or Alzheimer’s disease related disorders, including cardiovascular disease, prior stroke, use of blood thinners, and age over 85 years, would have been excluded them from the aducanumab clinical trials.

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Columbia University Irving Medical Center, its Herbert Irving Comprehensive Cancer Center, and Pfizer Inc. have established the Columbia-Pfizer Clinical Trials Diversity Initiative, with the aim of reducing health disparities by increasing the participation of underrepresented minorities in clinical trials and enhancing the diversity of clinical researchers.

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From tele-monitoring patients with diabetes to using artificial intelligence to prevent sepsis, the newly launched Center for Health Innovation will seek to develop, test and commercialize technologies that make a real, measurable difference in the lives and wellbeing of patients.

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SEATTLE — September 1, 2021 — Below are summaries of recent Fred Hutch research findings and other news.

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A primary analysis of an experimental HIV vaccine regimen being studied in a high-incidence population of young women in sub-Saharan Africa found the experimental vaccine did not provide sufficient protection against HIV infection.

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Researchers reviewed the recent major randomized, double-blind placebo-controlled trials and present an updated meta-analysis of hydroxychloroquine in post-exposure prophylaxis as well as in hospitalized patients.