Curated News: Journal of Experimental Medicine

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Newswise: Immune cells have a metabolic backup plan for accessing their anti-cancer playbook
Released: 23-Aug-2024 10:05 AM EDT
Immune cells have a metabolic backup plan for accessing their anti-cancer playbook
Van Andel Institute

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.

Newswise: Master autoimmune regulator gets by with a little help from its friends
Released: 27-Jun-2024 1:05 PM EDT
Master autoimmune regulator gets by with a little help from its friends
St. Jude Children's Research Hospital

See how St. Jude researchers investigated Foxp3 function as a transcription cofactor in regulatory T cells in immune system activation and suppression.

Newswise: Mutations protected mice from B-cell cancers
Released: 14-May-2024 3:05 PM EDT
Mutations protected mice from B-cell cancers
UT Southwestern Medical Center

By completely or even partially depleting a protein called midnolin in B cells, UT Southwestern Medical Center researchers suppressed leukemia and lymphoma in a mouse model genetically prone to these cancers. Their findings, reported in the Journal of Experimental Medicine, could lead to new treatments for these diseases that avoid the serious side effects of current therapies.

Newswise: Researchers identify new way to inhibit immune cells that drive allergic asthma
19-Mar-2024 9:05 AM EDT
Researchers identify new way to inhibit immune cells that drive allergic asthma
The Rockefeller University Press

Researchers at the Keck School of Medicine, University of Southern California, have discovered that a protein called Piezo1 prevents a type of immune cell in the lung from becoming hyperactivated by allergens.

Newswise: Newly identified yeast could prevent fungal infections by outcompeting rivals, study suggests
11-Mar-2024 10:05 AM EDT
Newly identified yeast could prevent fungal infections by outcompeting rivals, study suggests
The Rockefeller University Press

Researchers at the Weizmann Institute of Science in Israel have identified a yeast that could be used to prevent invasive candidiasis, a major cause of death in hospitalized and immunocompromised patients. The study, to be published March 18 in the Journal of Experimental Medicine (JEM), shows that the novel yeast lives harmlessly in the intestines of mice and humans and can displace the yeast responsible for candidiasis, Candida albicans.

Newswise: Turbocharging CRISPR to Understand How the Immune System Fights Cancer
Released: 29-Feb-2024 8:00 AM EST
Turbocharging CRISPR to Understand How the Immune System Fights Cancer
Harvard Medical School

Harvard Medical School scientists develop new CRISPR-based tool to study the immune function of genes. New gene-editing approach could optimize how scientists study the immune system’s role in cancer and other immune-mediated diseases.

Newswise: Study identifies new pathway to suppressing autoimmunity
25-Sep-2023 2:05 PM EDT
Study identifies new pathway to suppressing autoimmunity
The Rockefeller University Press

Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body’s own, healthy tissues. The study, to be published September 29 in the Journal of Experimental Medicine (JEM), also reveals how this process is impaired in autoimmune disorders such as systemic sclerosis and systemic lupus erythematosus and suggests potential new strategies to treat these diseases.

Newswise: Treating NASH disease by removing cholesterol from macrophages using a unique supramolecule
Released: 19-Sep-2023 2:05 PM EDT
Treating NASH disease by removing cholesterol from macrophages using a unique supramolecule
Nagoya University

A research group from the Graduate School of Medicine and Research Institute of Environmental Medicine at Nagoya University reported that cholesterol accumulation in macrophages promotes liver fibrosis in the development of non-alcoholic steatohepatitis (NASH).

Released: 24-Aug-2023 11:05 AM EDT
Training immune cells to remove ‘trash’ helps resolve lung inflammation
University of Illinois Chicago

Acute lung injury occurs when our lung’s immune system response becomes hyperactivated and causes inflammation to continue unchecked. In fact, many deaths from COVID-19 were from acute lung injury.

Newswise: Mutations in blood stem cells can exacerbate colon cancer
21-Aug-2023 9:45 AM EDT
Mutations in blood stem cells can exacerbate colon cancer
The Rockefeller University Press

Researchers at the University of Florida College of Medicine have discovered how common age-related changes in the blood system can make certain colon cancers grow faster.

Newswise: Neuroscientists create new resource to improve Alzheimer’s disease research models
Released: 23-Aug-2023 7:30 AM EDT
Neuroscientists create new resource to improve Alzheimer’s disease research models
Indiana University

A new study by Indiana University School of Medicine researchers uses more genetically diverse mouse models to study the accumulation and spread of abnormal tau protein deposits in the brain.

Released: 3-Jul-2023 3:05 PM EDT
Researchers Identify a New Mechanism, Cancer Hijacks Enzyme Substrate Motif Mutations
University of North Carolina School of Medicine

Enzyme mutations have been of great interest to scientists who study cancer. Scientists in the Liu and Tan labs at UNC’s Lineberger Comprehensive Cancer Center have been studying mutations of enzyme recognition motifs in substrates, which may more faithfully reflect enzyme function with the potential to find new targets or directions for cancer treatment.

Newswise: Researchers Use ‘Natural’ System to Identify Proteins Most Useful For Developing an Effective HIV Vaccine
Released: 30-May-2023 2:00 PM EDT
Researchers Use ‘Natural’ System to Identify Proteins Most Useful For Developing an Effective HIV Vaccine
Johns Hopkins Medicine

Scientists have spent years trying to develop an effective HIV vaccine, but none have proven successful. Based on findings from a recently published study, a Johns Hopkins Medicine-led research team may have put science one step closer to that goal.

Newswise: Researchers discover how some brain cells transfer material to neurons in mice
Released: 17-Apr-2023 3:35 PM EDT
Researchers discover how some brain cells transfer material to neurons in mice
UC Davis Health

A UC Davis study is the first to report on a material transfer mechanism from cells, known as oligodendrocytes, to neurons in the brain of a mouse model. This discovery opens new possibilities for understanding brain maturation and finding treatments for many neurological conditions.

   
Newswise: Study to decode microbe-gut signaling suggests potential new treatment for IBD
Released: 4-Apr-2023 1:00 PM EDT
Study to decode microbe-gut signaling suggests potential new treatment for IBD
Cincinnati Children's Hospital Medical Center

Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.

Newswise: Can Controlling Retinoic Acid be a Key to Preventing Infections in the Gut?
Released: 28-Mar-2023 1:55 PM EDT
Can Controlling Retinoic Acid be a Key to Preventing Infections in the Gut?
Stony Brook University

A team of scientists from the Renaissance School of Medicine (RSOM) at Stony Brook University have identified a distinct role of retinoic acid, a metabolite of vitamin A, during the immune response of the gut.

Newswise: Insights into causes of rare genetic immune disorders
Released: 21-Mar-2023 3:55 PM EDT
Insights into causes of rare genetic immune disorders
Garvan Institute of Medical Research

The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research.

Newswise: New gene-editing technique reverses vision loss in mice
13-Mar-2023 9:55 AM EDT
New gene-editing technique reverses vision loss in mice
The Rockefeller University Press

Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans. The study, to be published March 17 in the Journal of Experimental Medicine, uses a new, highly versatile form of CRISPR-based genome editing with the potential to correct a wide variety of disease-causing genetic mutations.

Newswise: 新的基因编辑技术成功地逆转小鼠的视力损失
13-Mar-2023 9:55 AM EDT
新的基因编辑技术成功地逆转小鼠的视力损失
The Rockefeller University Press

视网膜色素变性症是人类失明的主要原因之一。中国的研究人员成功地恢复了患有视网膜色素变性症的小鼠的视力。该研究将于[三月十七日]发表在《实验医学杂志》上。该研究使用一种新型的、高度通用的CRISPR基因组编辑技术,有潜力纠正各种导致疾病的遗传突变。

Released: 8-Mar-2023 5:50 PM EST
Research Highlights for February 2023
University of Utah Health

Read how researchers discovered genetic markers that hinder pancreatic cancer treatment and mutations that increase sarcoma risk. Then learn how artificial intelligence is helping predict prostate cancer outcomes and see how a new clinical trial looks at less-invasive breast cancer treatments. Finally, find out how a new grant could help veterans get the cancer care they need.



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