Curated News: Journal of Experimental Medicine

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Newswise: Could cancer immunotherapy success depend on gut bacteria?
Released: 6-Mar-2020 3:40 PM EST
Could cancer immunotherapy success depend on gut bacteria?
UT Southwestern Medical Center

Gut bacteria can penetrate tumor cells and boost the effectiveness of an experimental immunotherapy that targets the CD47 protein.

Newswise: Gut bacteria can penetrate tumors and aid cancer therapy, study suggests
2-Mar-2020 8:45 AM EST
Gut bacteria can penetrate tumors and aid cancer therapy, study suggests
The Rockefeller University Press

Researchers at the University of Texas Southwestern Medical Center and University of Chicago have discovered that bacteria that usually live in the gut can accumulate in tumors and improve the effectiveness of immunotherapy in mice. The study, which will be published March 6 in the Journal of Experimental Medicine (JEM), suggests that treating cancer patients with Bifidobacteria might boost their response to CD47 immunotherapy, a wide-ranging anti-cancer treatment that is currently being evaluated in several clinical trials.

Newswise: Activating Immune Cells Could Revitalize the Aging Brain, Study Suggests
29-Jan-2020 8:05 AM EST
Activating Immune Cells Could Revitalize the Aging Brain, Study Suggests
The Rockefeller University Press

Researchers at Albany Medical College in New York have discovered that a specific type of immune cell accumulates in older brains, and that activating these cells improves the memory of aged mice. The study, which will be published February 5 in the Journal of Experimental Medicine (JEM), suggests that targeting these cells might reduce age-related cognitive decline and combat aging-associated neurodegenerative disease in humans.

Newswise: Breaking the dogma: Key cell death regulator has more than one way to get the job done
Released: 23-Dec-2019 1:55 PM EST
Breaking the dogma: Key cell death regulator has more than one way to get the job done
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process. The findings appeared online today in the Journal of Experimental Medicine.

Newswise: Scientists Find Molecular Key to Body Making Healthy T Cells
24-Oct-2019 11:05 AM EDT
Scientists Find Molecular Key to Body Making Healthy T Cells
Cincinnati Children's Hospital Medical Center

In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.

Newswise: Creatine powers T cells’ fight against cancer
Released: 18-Oct-2019 12:05 PM EDT
Creatine powers T cells’ fight against cancer
UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research

The study, conducted in mice, is the first to show that creatine uptake is critical to the anti-tumor activities of killer T cells, the foot soldiers of the immune system.

Newswise: Researchers Identify New Therapeutic Target for Pulmonary Fibrosis
7-Oct-2019 9:00 AM EDT
Researchers Identify New Therapeutic Target for Pulmonary Fibrosis
The Rockefeller University Press

Researchers in Japan have identified a genetic mutation that causes a severe lung disease called idiopathic pulmonary fibrosis (IPF) by killing the cells lining the lung’s airways. The study, which will be published October 10 in the Journal of Experimental Medicine (JEM), suggests that protecting these cells by inhibiting a cell death pathway called necroptosis could be a new therapeutic approach to treating IPF.

Newswise:Video Embedded targeting-immune-cells-may-be-potential-therapy-for-alzheimer-s
VIDEO
7-Oct-2019 5:05 PM EDT
Targeting immune cells may be potential therapy for Alzheimer’s
Washington University in St. Louis

A study from Washington University School of Medicine in St. Louis has found that microglia drive neurodegeneration in diseases, including Alzheimer's disease, that are linked to tau protein. Targeting microglia may help treat such diseases.

Newswise: Birth defects associated with Zika virus infection may depend on mother’s immune response, study suggests
7-Aug-2019 8:05 AM EDT
Birth defects associated with Zika virus infection may depend on mother’s immune response, study suggests
The Rockefeller University Press

New research led by scientists at The Rockefeller University in New York may help explain why Zika virus infection causes birth defects in some children but not others. The study, which will be published August 14 in the Journal of Experimental Medicine, suggests that the risk of developing an abnormally small head (microcephaly) depends on the types of antibody produced by pregnant mothers in response to Zika infection.

Newswise: Precision Editing of Gut Bacteria Reduces Cancer in Mice
Released: 31-Jul-2019 5:00 PM EDT
Precision Editing of Gut Bacteria Reduces Cancer in Mice
UT Southwestern Medical Center

UT Southwestern researchers have shown that precision editing of the bacterial populations in the gut reduces inflammation-associated colorectal cancer in mice.


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