Feature Channels: Liver Disease

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Released: 2-Jul-2020 12:30 PM EDT
Tiny mineral particles are better vehicles for promising gene therapy
University of Wisconsin-Madison

University of Wisconsin–Madison researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination — including a COVID-19 vaccine from Moderna Therapeutics that has advanced to clinical trials with humans.

Newswise: Universal Gut Microbiome-Derived Signature Predicts Cirrhosis
Released: 30-Jun-2020 1:05 PM EDT
Universal Gut Microbiome-Derived Signature Predicts Cirrhosis
University of California San Diego Health

UC San Diego School of Medicine researchers report that stool microbiomes of NAFLD patients are distinct enough to potentially be used to accurately predict which persons with NAFLD are at greatest risk for having cirrhosis.

Released: 29-Jun-2020 12:05 PM EDT
The Gut Shields the Liver from Fructose-Induced Damage
Perelman School of Medicine at the University of Pennsylvania

After one consumes food or a beverage containing fructose, the gut helps to shield the liver from damage by breaking down the sugar. However, the consumption of too much fructose can overwhelm the gut, causing fructose to “spill over” into the liver, where it wreaks havoc and causes fatty liver, researchers discovered.

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Released: 17-Jun-2020 11:20 AM EDT
Liver perfusion could save 7 in 10 rejected donor livers
University of Birmingham

A major study investigating the effectiveness of liver perfusion as a technique to improve the function of donor livers that would have otherwise been rejected has shown that up to 7 in every 10 could be used after just 4-6 hours of the assessment.

Newswise: Novel Antisense Drug Shows Promise in Slowing Fatty Liver Disease
Released: 16-Jun-2020 1:20 PM EDT
Novel Antisense Drug Shows Promise in Slowing Fatty Liver Disease
University of California San Diego Health

A first-in-class clinical trial suggests a novel treatment measurably slowed progression of non-alcoholic fatty liver disease to its more progressive and deadly form.

Newswise: Link between liver and heart disease could lead to new therapeutics
5-Jun-2020 10:45 AM EDT
Link between liver and heart disease could lead to new therapeutics
Iowa State University

A newly published study of flies found that protecting liver function also preserves heart health. The research could lead to new therapeutic approaches in human health and illuminate the role of understudied organelles known as peroxisomes.

Released: 20-May-2020 10:35 AM EDT
New Liver Cancer Research Targets Non-Cancer Cells to Blunt Tumor Growth
Perelman School of Medicine at the University of Pennsylvania

“Senotherapy,” a treatment that uses small molecule drugs to target “senescent” cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, PhD, a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute. The study was published in Nature Cell Biology.

Newswise: New treatment extends lives of people with most common type of liver cancer
11-May-2020 11:20 AM EDT
New treatment extends lives of people with most common type of liver cancer
University of California, Los Angeles (UCLA), Health Sciences

For the first time in over a decade, scientists have identified a first-line treatment that significantly improves survival for people with hepatocellular carcinoma, the most common type of liver cancer.

Released: 7-May-2020 1:50 PM EDT
Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences
Society of Toxicology

During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.

Newswise: Racial Inequalities in Liver Cancer Deaths Soared After Launch of Hepatitis C Drugs
Released: 30-Apr-2020 3:55 PM EDT
Racial Inequalities in Liver Cancer Deaths Soared After Launch of Hepatitis C Drugs
Florida Atlantic University

A study explored racial inequalities in death from liver cancer before and after the introduction of lifesaving drugs for hepatitis C. Results showed that from 1979 to 1998, racial inequalities in mortality from liver cancer in the U.S. were declining. But, from 1998 to 2016, of the 16,770 deaths from liver cancer among blacks, the excess relative to whites increased from 27.8 percent to 45.4 percent. Concurrently, racial inequalities in death decreased for major risk factors for liver cancer, such as alcohol and diabetes.

Newswise: Researchers receive $2.8 million grant to develop blood-based test for liver transplant candidate selection
Released: 27-Apr-2020 1:55 PM EDT
Researchers receive $2.8 million grant to develop blood-based test for liver transplant candidate selection
University of California, Los Angeles (UCLA), Health Sciences

Researchers from the UCLA Jonsson Comprehensive Cancer Center received a $2.8 million, five-year grant from the National Cancer Institute to help develop a blood-based test to improve the selection and prioritization for patients with liver cancer who need a liver transplantation.

Released: 14-Apr-2020 12:25 PM EDT
Therapies show knockout potential for rare, deadly liver cancer
Cornell University

A new study identifies some of the most critical genes that may drive a rare but deadly liver cancer, providing a road map for developing drugs that target those genes.

Newswise: UC San Diego to Advance Stem Cell Therapies in New Space Station Lab
Released: 8-Apr-2020 3:45 PM EDT
UC San Diego to Advance Stem Cell Therapies in New Space Station Lab
University of California San Diego Health

UC San Diego and Space Tango received a NASA award to develop the first dedicated stem cell research laboratory within the International Space Station.

Released: 7-Apr-2020 4:25 PM EDT
Hangover drug shows wider benefits in USC research
University of Southern California (USC)

A well-known hangover drug not only helps soothe pounding headaches but also triggers profound changes that protect the liver, USC scientists report in new findings that could help prevent alcohol-related harm.

Released: 6-Apr-2020 5:10 PM EDT
Researchers Identify Potential Early Biomarker to Track Development of Dangerous Non-alcoholic Fatty Liver Disease
Joslin Diabetes Center

Fatty liver disease not associated with alcohol consumption, which is called Nonalcoholic Fatty Liver Disease or NAFLD, affects more than one billion people worldwide. Even in children the numbers are overwhelming, with up to 80 percent of pediatric patients who are considered obese affected worldwide. People with NAFLD can progress to a severe form known as nonalcoholic steatohepatitis (NASH), which puts patients at higher risk for cirrhosis or liver cancer.

26-Mar-2020 11:05 AM EDT
Bariatric surgery may be effective treatment for non-alcoholic fatty liver disease
Endocrine Society

Bariatric surgery may be an effective treatment for non-alcoholic fatty liver disease (NAFLD), suggests a new study accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting, and publication in the Journal of the Endocrine Society.

26-Mar-2020 12:10 PM EDT
Three non-invasive methods used to predict who has NASH agree only about 20% of the time
Endocrine Society

Researchers and clinicians have been trying to find a way to diagnose nonalcoholic steatohepatitis (NASH) without taking a liver tissue biopsy, but according to new research, formulas that aim to predict NASH based on risk factors do not agree with each other and their accuracy varies. The study was accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society.

Released: 30-Mar-2020 4:50 PM EDT
Read-Across of Chemical Hepatotoxicants; Exposure-Based Cholinergic Synaptic Functional Deficits; and More Featured in April 2020 Toxicological Sciences
Society of Toxicology

The April 2020 issue of the Society of Toxicology’s official journal, Toxicological Sciences, features leading research in toxicology, including several manuscripts covering emerging technologies, methods, and models.

Released: 25-Mar-2020 1:15 PM EDT
AASLD Releases Clinical Insight Guide for Treating Patients with Liver Disease and COVID-19
American Association for the Study of Liver Diseases (AASLD)

The American Association for the Study of Liver Disease (AASLD) has released a clinical insight document for clinicians and frontline healthcare providers who are treating patients with liver disease during the COVID-19 pandemic. The document, which cites recent studies conducted in China, assesses how hepatologists and liver transplant physicians/surgeons and their patients may be affected by the COVID-19 virus (also known as SARS-CoV-2) and provides continued guidance on clinical approaches to disease management.

Released: 5-Mar-2020 9:40 AM EST
Vinyl Chloride, Nerve Growth Factor, Chemical Warfare, and More Examined in March 2020 Toxicological Sciences
Society of Toxicology

The March 2020 issue of Toxicological Sciences features leading research in toxicology, covering investigations in biotransformation, toxicokinetics, and pharmacokinetics in addition to work in exposure sciences and environmental toxicology.

Newswise:Video Embedded how-resident-microbes-restructure-body-chemistry
VIDEO
24-Feb-2020 12:45 PM EST
How Resident Microbes Restructure Body Chemistry
University of California San Diego Health

A comparison of normal and germ-free mice revealed that as much as 70 percent of a mouse’s gut chemistry is determined by its gut microbiome. Even in distant organs, such as the uterus or the brain, approximately 20 percent of molecules were different in the mice with gut microbes.

26-Feb-2020 10:00 AM EST
New bile discovery will rewrite textbooks
Michigan State University

Forget what you know about bile because that's about to change, thanks to a new discovery made by Michigan State University and published in the current issue of Nature. Much of our knowledge about bile hasn’t changed in many decades. It’s produced in the liver, stored in our gall bladder and injected into our intestine when we eat, where it breaks down fats in our gut.

Released: 25-Feb-2020 7:00 AM EST
Think Before You Drink: The Brain Plays a Role in Alcoholic Fatty Liver Disease
American Physiological Society (APS)

New research shows that two brain proteins help regulate fat accumulation in the liver associated with excessive alcohol consumption, specifically binge drinking. The study is published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism.

Released: 24-Feb-2020 4:15 PM EST
Too Much of a Good Thing May Lead to Too Much of a Liver As Well
University of California San Diego Health

UC San Diego researchers suggest that prolonged exposure to a pair of antioxidant proteins may contribute to enlargement of the liver and fatty liver diseases.

Released: 24-Feb-2020 11:05 AM EST
Cardiac amyloidosis masquerades as other conditions; 1 type affects more black Americans
Mayo Clinic

Human bodies constantly produce thousands of perfectly folded proteins, but some proteins get misfolded. An excess of these misfolded proteins can overwhelm the body's ability to remove them. When that happens, the rogue proteins bind together and form a substance called amyloid. Webs of amyloid can deposit in any tissue or organ, but some types affect the heart.

Released: 14-Feb-2020 7:05 PM EST
研究发现,特定肝细胞将有助于预防器官移植后的排斥反应和其他问题
Mayo Clinic

脂肪组织和骨髓中的间充质基质细胞因具有抗炎特性而被广泛用于各类治疗试验,但Mayo Clinic的一项新研究发现,肝细胞在这方面可能具有更大的潜质。

Released: 14-Feb-2020 12:10 PM EST
New Guidelines for Hepatic Failure in the Intensive Care Unit
Wolters Kluwer Health: Lippincott Williams and Wilkins

For critical care specialists, hepatic failure poses complex challenges unlike those of other critical illnesses. A new set of evidence-based recommendations for management of liver failure is presented in the March issue of Critical Care Medicine, the official journal of the Society of Critical Care Medicine (SCCM). The journal is published in the Lippincott portfolio by Wolters Kluwer. The guidelines are being presented at the SCCM 49th Critical Care Congress.

10-Feb-2020 9:00 AM EST
CRISPR “Minigene” Approach Stops Genetic Liver Disease in Mice
Perelman School of Medicine at the University of Pennsylvania

A new CRISPR gene-editing technique prevented a genetic liver disease known to be driven by hundreds of different mutations and improved clinical symptoms in mice

Released: 12-Feb-2020 8:55 AM EST
Um estudo descobriu que certas células hepáticas podem ajudar a prevenir a rejeição de órgãos depois de um transplante e outras doenças
Mayo Clinic

As células-tronco mesenquimais do tecido adiposo e da medula óssea são amplamente utilizadas em ensaios terapêuticos por suas propriedades anti-inflamatórias, mas uma nova pesquisa da Mayo Clinic descobriu que as células hepáticas podem ser de maior valor.

Released: 12-Feb-2020 8:55 AM EST
خلايا كَبِديَّة قد تساعد على الوقاية من رفض العضو بعد زراعته وعلاج حالات أخرى، نتائج الدراسة
Mayo Clinic

ينتشر استخدام الخلايا السَّدَويَّة اللحمية المتوسطية من النسيج الدهني والنخاع العظمي في التجارب العلاجية، وذلك بسبب مزاياها المُضادة للالتهابات، ولكن البحث الحديث في Mayo Clinic اكتشف أن خلايا الكَبِد قد تكون ذات قيمة أكبر.

Released: 12-Feb-2020 8:55 AM EST
Laut einer Studie können bestimmte Leberzellen der Organabstoßung nach einer Transplantation und anderen Erkrankungen vorbeugen
Mayo Clinic

Mesenchymale Stromazellen aus Fettgewebe und Knochenmark werden wegen ihrer entzündungshemmenden Eigenschaften häufig in therapeutischen Studien eingesetzt, doch neue Forschungsergebnisse von Mayo Clinic zeigen, dass Leberzellen möglicherweise von größerem Nutzen sind.

Released: 12-Feb-2020 8:50 AM EST
Selon une étude, certaines cellules du foie pourraient contribuer à prévenir le rejet d'organe après une greffe ainsi que d'autres pathologies
Mayo Clinic

Les cellules mésenchymateuses stromales provenant du tissu adipeux et de la moelle osseuse sont largement utilisées dans les essais thérapeutiques pour leurs qualités anti-inflammatoires. Mais de nouvelles recherches menées par Mayo Clinic montrent que les cellules du foie pourraient représenter une valeur plus importante.

Newswise: Cedars-Sinai to Study How Fat May Promote Cancer Spread to Liver
Released: 6-Feb-2020 2:20 PM EST
Cedars-Sinai to Study How Fat May Promote Cancer Spread to Liver
Cedars-Sinai

A diagnosis of pancreatic or colon cancer often sparks dread about the disease's likely next destination: the liver. That's because liver metastasis is a leading cause of death in these patients. A Cedars-Sinai scientific team has been awarded a $9.1 million grant by the National Cancer Institute to study this often-fatal process, with the goal of understanding how cancer spreads to the liver and finding ways to block it.

Newswise: Study: Two Enzymes Control Liver Damage in NASH
4-Feb-2020 1:40 PM EST
Study: Two Enzymes Control Liver Damage in NASH
University of California San Diego Health

After identifying a molecular pathway that allows nonalcoholic steatohepatitis (NASH) to progress into liver cell death, University of California San Diego School of Medicine researchers were able to use these pathways to halt further liver damage.

Newswise: Choosing Common Pain Relievers: It’s Complicated
Released: 5-Feb-2020 8:30 AM EST
Choosing Common Pain Relievers: It’s Complicated
Florida Atlantic University

About 29 million Americans use over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain. Every year in the U.S., NSAID use is attributed to approximately 100,000 hospitalizations and 17,000 deaths. All of these drugs have benefits and risks, but deciding which one to use is complicated for health care providers and their patients. To assist in clinical decision-making, researchers address cardiovascular risks and beyond, which include gastrointestinal and kidney side effects of pain relievers.

Released: 3-Feb-2020 3:45 PM EST
Shift in treatment modalities associated with improved outcomes in uveal melanoma patients with liver metastasis
Thomas Jefferson University

New retrospective study indicates that the shift of treatment from systemic chemotherapies to liver-directed therapies provides survival benefits.

Released: 28-Jan-2020 7:00 AM EST
Low-protein Diet in Pregnancy May Lead to Mom’s Liver Damage
American Physiological Society (APS)

A study in rats examines a pathway through which protein deficiency during pregnancy leads to fat accumulation in the liver and increased risk of liver damage. The first-of-its-kind study is published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism.

Released: 23-Jan-2020 1:45 PM EST
Liver Fibrosis 'Off Switch' Discovered in Mice
University of California San Diego Health

UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis.

Released: 22-Jan-2020 5:05 PM EST
Ciertas células hepáticas pueden prevenir rechazo del órgano después del trasplante y otras afecciones, descubre estudio
Mayo Clinic

Las células mesenquimales del estroma procedentes del tejido graso y de la médula ósea se emplean ampliamente en ensayos terapéuticos por sus cualidades antiinflamatorias, pero un nuevo estudio de Mayo Clinic descubre que las células hepáticas podrían ser más valiosas.

Released: 20-Jan-2020 2:25 PM EST
Certain liver cells may help prevent organ rejection after transplant and other conditions, study finds
Mayo Clinic

Mesenchymal stromal cells from fat tissue and bone marrow are widely used in therapeutic trials for their anti-inflammatory qualities, but new Mayo Clinic research finds that liver cells may be of greater value. The study, published in Liver Transplantation, finds that liver mesenchymal stromal cells have immunoregulatory qualities that make them more effective than similar cells derived from adipose, or fat, tissue and bone marrow.

Released: 20-Jan-2020 10:50 AM EST
New Drug Prevents Liver Damage, Obesity and Glucose Intolerance in Mice on High-Fat Diet
Georgetown Lombardi Comprehensive Cancer Center

Mice given a new drug targeting a key gene involved in lipid and glucose metabolism could tolerate a high-fat diet regimen (composed of 60% fat from lard) without developing significant liver damage, becoming obese, or disrupting their body’s glucose balance.

Newswise: John Theurer Cancer Center Participating in Early-Phase Study of Immunotherapy-Boosting Treatment
Released: 16-Jan-2020 1:55 PM EST
John Theurer Cancer Center Participating in Early-Phase Study of Immunotherapy-Boosting Treatment
Hackensack Meridian Health

Investigators at John Theurer Cancer Center at Hackensack University Medical Center in New Jersey are participating in a first-in-patients clinical trial assessing VE800, a novel bacteria-containing therapy, in combination with the immunotherapy drug nivolumab. Laboratory research has suggested that VE800 may enhance the effectiveness of drugs like nivolumab.

14-Jan-2020 12:05 PM EST
Heterogeneity of Liver Cancer Cells Helps Explain Tumor Progression in Patients, Mount Sinai Research Found
Mount Sinai Health System

Many liver cancer tumors contain a highly diverse set of cells, a phenomenon known as intra-tumor heterogeneity that can significantly affect the rate at which the cancer grows, Mount Sinai researchers report. The immune system’s contribution to this heterogeneity can have major clinical implications.

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Released: 13-Jan-2020 1:15 PM EST
Machine keeps human livers alive for one week outside of the body
University of Zurich

Researchers from the University Hospital Zurich, ETH Zurich, Wyss Zurich and the University of Zurich have developed a machine that repairs injured human livers and keeps them alive outside the body for one week.

Released: 13-Jan-2020 12:50 PM EST
'Ageotypes' provide window into how individuals age, Stanford study reports
Stanford University School of Medicine

What's your type? That question could gain new meaning, thanks to scientists who've categorized how humans age into different classes dubbed "ageotypes," reports a new study from the Stanford University School of Medicine.

Released: 7-Jan-2020 9:00 AM EST
New Guideline on Disorders of Hepatic and Mesenteric Circulation Published by American College of Gastroenterology
American College of Gastroenterology (ACG)

A new clinical guideline addresses common disorders of the mesenteric, portal, and hepatic veins and mesenteric and hepatic arteries.


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