Drosophila ovarian Follicle Stem Cells (FSCs) present a favorable paradigm for understanding how stem cell division and differentiation are balanced in communities where they can be regulated independently.
Artificial human blastoids investigate fundamentals of early embryo development using in vitro models and study the pregnancy failures and birth deficiencies, previously hindered by the need for human embryos.
Adipose tissue (AT) is recognized as a complex organ involved in major home-ostatic body functions, such as food intake, energy balance, immunomodulation, development and growth, and functioning of the reproductive organs. The role of AT in tis
Muscle weakness and atrophy are clinical hallmarks of myotonic dystrophy type 1 (DM1). Muscle stem cells, which contribute to skeletal muscle growth and repair, are also affected in this disease. However, the molecular mechanisms leading to this defective activity and the impact on the disease severity are still elusive. Here, we explored through an unbiased approach the molecular signature leading to myogenic cell defects in DM1.
Cell-intrinsic response patterns control risks arising from genome-damaged cells, preventing malignant transformation. p53-dependent DNA damage responses halt the cell cycle and induce either repair, senescence or cell death. Cyclic-GMP-AMP synthase (cGAS) has emerged as a new principle detecting genome damage and activating complex response programs.
Neha Paranjape, Yu-Hsiu Tony Lin, Quetzal Flores-Ramirez, Vishesh Sarin, Amanda Brooke Johnson, Julia Chu, Mercedes Paredes, Arun P. Wiita
Human pluripotent stem cells (hPSCs) have become a powerful tool to generate various kinds of cell types comprising the human body. Recently, organoid technology emerged as a platform to build a physiologically relevant tissue-like structure from the PSCs, which provides a more relevant three-dimensional microenvironment to the actual human body than the conventional monolayer culture system for transplantation, disease modeling, and drug development.
Previous studies of the murine Ly49 and human KIR gene clusters have revealed a role for bidirectional promoters in the control of variegated gene expression. Whether or not competing promoters control other instances of cell fate determination remains an outstanding question.
The epithelial and interstitial stem cells of the freshwater polyp Hydra are the best characterized stem cell systems in any cnidarian, providing valuable insight into cell type evolution and the origin of stemness in animals.
Canine renal ischemia-reperfusion (IR) causes severe acute kidney injury characterized by renal dysfunction and inflammatory disorder.
Neural crest cells (NCCs), a multipotent stem cell population, contribute to cardiac development as a source of the outflow septum, vascular smooth muscle and semilunar valves. However, genetic programs underlying lineage diversification of cardiac NCCs remain largely unknown.
Auxin plays pleiotropic roles in plant development via gene regulation upon perception by the receptors TRANSPORT INHIBITOR RESPONSE 1/AUXIN SIGNALING F-BOX (TIR1/AFBs). This nuclear auxin signaling (NAS) originated in the common ancestor of land plants.
Cell culture at liquid-liquid interfaces, for example at the surface of oil microdroplets, is an attractive strategy to scale up adherent cell manufacturing whilst replacing the use of microplastics.
Weimin Zhang, Ilona Golynker, Ran Brosh, Aleksandra M. Wudzinska, Yinan Zhu, Lucia Carrau, Payal Damani-Yokota, Camille Khairallah, Noor Chalhoub, Emily Huang, Hannah Ashe, Kamal M. Khanna, Matthew T. Maurano, Sang Yong Kim,
Relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allogeneic stem cell transplantation (allo-HCT) still represents a major concern with poor outcomes.
Bone marrow (BM) stroma plays key roles in supporting hematopoietic stem cell (HSC) growth.
Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with varios metaplastic components.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and a leading cause of dementia.
This study aimed to investigate the effects and mechanisms of miRNA-140 in exosomes of hypoxic bone marrow mesenchymal stem cells on articular chondrocytes. Articular chondrocytes were stimulated with IL-1β (10 μg/ml) to give them an inflammatory state.
Diabetic foot (DF) is one of the most common and serious complications of diabetes mellitus (DM), which brings great psychological and economic pressure to patients. This study aimed to evaluate the efficacy of stem cells in the treatment of diabetic foot.
Endogenous retroviruses (ERVs) have rewired host gene networks through co-option of their enhancers.
TANGO2-deficient disorder (TDD) is an autosomal recessive genetic disease caused by biallelic loss-of-function variants in TANGO2 gene.
RNA-binding proteins (RBPs) are pivotal for regulating gene expression as they are involved in each step of RNA metabolism.
Matteo Togninalli, Andrew T.V. Ho, Christopher M Madl, Colin A. Holbrook, Yu Xin Wang, Klas E.G. Magnusson, Anna Kirillova, Andrew Chang, Helen Blau
One of the most devastating aspects of stroke and traumatic brain injury is that the neurons we lose are never replaced.
Fabiana Faleiros, Deyse Braga, Soraia Dornelles Schoeller, Sílvia Helena Henriques, Naira Beatriz Favoretto Cunha, Lorena Gomes Neves Videira, Adriana Cordeiro Leandro Silva Grillo
Daniel Levy, Anjana Jeyaram, Louis J Born, Kai-Hua Chang, Sanaz Nourmohammadi Abadchi, Angela Ting Wei Hsu, Talia Solomon, Amaya Aranda, Samantha Stewart, XiaoMing He, John W Harmon, Steven M Jay
Donna L McPhie, Boyu Ren, Juan Antonio Garcıa-Leon, Catherine M Verfaillie, Bruce M Cohen
Keisuke Kozai, Ayelen Moreno Irusta, Khursheed Iqbal, Mae-Lan Winchester, Regan L Scott, Mikaela E Simon, Masanaga Muto, Marc R Parrish, Michael J Soares
Yongkang Yang, David Z. Chen, Sergio Rey, Jun O. Liu, Gregg L. Semenza
Mehmet Kural, Umidahan Djakbarova, Bilal Cakir, Yoshiaki Tanaka, Yasaman Madraki, Hong Qian, Jinkyu Park, Lorenzo Sewanan, Comert Kural, Laura Niklason
Erik Jacques, Yinni Kuang, Allison P Kann, Robert S Krauss, Penney M Gilbert
Nicholas Daniel Henkel, Alex Joyce, Elizabeth Shedroff, Ali Sajid Imami, Khaled Alganem, Abdul-Rizaq Hamoud, Chongchong Xu, Benjamin Siciliano, Tao Ma, Zhexing Wen, Robert Erne McCullumsmith
Hisao Masai, Youichi Tajima, Futoshi Shibazaki
Zhiqiang Wang, Leilei Li, Wanpu Wang, Lilin Luo, Shuai Dong, Menglong Li, Tianxing Chen, Qingyang Meng, Rui Liang
Evdokiia Potolitsyna, Sarah Hazell Pickering, Ave Tooming-Klunderud, Philippe Collas, Nolwenn Briand
Marija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.
Julianne N.P. Smith, Brittany A Cordova, Brian Richardson, Kelsey F Christo, Jordan Campanelli, Alyssia V Broncano, Jonathan Chen, Juyeun Lee, Scott J Cameron, Justin D Lathia, Wendy A Goodman, Mark J Cameron, Amar B Desai
Jéssica Rodrigues Orlandin, Sarah Ingrid Pinto Santos, Luciana Cristina Machado, Paulo Fantinato Neto, Fabiana Fernandes Bressan, Naira Caroline Godoy Pieri, Kaiana Recchia, Meline de Paula Coutinho, Priscilla Avelino Ferreira Pinto, Annalisa Santucci, Valter Travagli, Carlos Eduardo Ambrosio
Lingli Gong, Ying Yin, Cheng Chen, Quan Wan, Die Xia, Mei Wang, Zhening Pu, Bo Zhang, Jian Zou
Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser, Cord Sunderkoetter, Jörg H. W. Distler, Margitta Worm, Alexander Kreuter, Gernot Keyzer, Hanns-Martin Lorenz, Thomas Krieg, Nicolas Hunzelmann, Joerg Henes
Hani Jieun Kim, Michelle Ohara-Wright, Daniel Kim, To Ha Loi, Benjamin Y Lim, Robyn V Jamieson, Anai Gonzalez Cordero, Pengyi Yang
Sha Yin, Wenjin Gao, Ye Fan, Rui Xia, Mingyue Duan, Xi Zhang, Ansheng Liu, Yanmin Zhang
Gregory W Roloff, Reid Shaw, Timothy E O'Connor, Michael W Drazer
Sangeeta Ghuwalewala, Kevin Jiang, Sara Ragi, David Shalloway, Tudorita Tumbar
Parisa Kangari, Leila Roshangar, Aida Iraji, Tahereh Talaei-Khozani, Mahboobeh Razmkhah
As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems. One of these is age-related macular degeneration, which affects the macula — the back part of the eye that gives us sharp vision and the ability to distinguish details.
Terry Hermiston, Jonathan Hardy, Maxine Bauzon, Francis G Blankenberg, Masamitsu Kanada, Ashley Makela, Charles K. F. Chan, Christopher H Contag
Pei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang, Haibo Xiao
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