UCLA researchers have found that embryonic stem cells and skin cells reprogrammed into embryonic-like cells have inherent molecular differences, demonstrating for the first time that the two cell types are clearly distinguishable from one another.
A gene well known to stop or suppress cancer plays a role in cancer stem cells, according to a new study from the University of Michigan Comprehensive Cancer Center. The researchers found that several pathways linked to the gene, called PTEN, also affected the growth of breast cancer stem cells.
Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood. Two papers next week in Cell and Nature show that the mechanical stresses of a beating heart and blood flow are required for the blood system to develop, and offer clues that may help in developing cell-based therapies for blood diseases such as leukemia, immune deficiency and sickle cell anemia.
Using cancer cells from an ovarian cancer patient, human embryonic stem cells and mice, Israeli researchers have created a pre-clinical experimental model that mimics the way a tumor would develop in the patient's body. The researchers say their findings could facilitate the development of personalized cancer therapies.
Dalhousie Medical School researchers have discovered that embryonic stem cells may play a critical role in helping people with nerve damage and motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), regain muscular strength.
A novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. For the first time researchers have demonstrated that cells expressing the marker can differentiate into both liver cells and cells that line the bile duct.
Researchers at the University of Southern California (USC) have identified a novel mechanism in the regulation and differentiation of neural stem cells. Researchers found that the protein receptor Ryk has a key role in the differentiation of neural stem cells, and demonstrated a signaling mechanism that regulates neuronal differentiation as stem cells begin to grow into neurons.
Ten years ago today (Nov. 6, 1998), the publication in the journal Science of a short paper entitled "Embryonic Stem Cell Lines Derived from Human Blastocysts" rocked biology "“ and the world "“ as the all-purpose stem cell and its possibilities were ushered into the limelight.
Researchers have shown that immune-defense cells influenced by embryonic stem cell-derived cells can help prevent the rejection of hearts transplanted into mice, all without the use of immunosuppressive drugs.
Mayo Clinic investigators have demonstrated that stem cells can be used to regenerate heart tissue to treat dilated cardiomyopathy, a congenital defect. Publication of the discovery was expedited by the editors of Stem Cells and appeared online in the "express" section of the journal's Web site at http://stemcells.alphamedpress.org/.
Using the molecular equivalent of a tattoo on DNA that adult stem cells (ASC) pass to their "daughter" cells in combination with gene expression profiles, University of Utah researchers have identified two early steps in adult stem cell differentiation"”the process that determines whether cells will form muscle, neurons, skin, etc., in people and animals.
Researchers from the Harvard Stem Cell Institute and Stem Cell Program at Children's Hospital Boston have produced a robust new collection of disease-specific stem cell lines, all of which were developed using the new induced pluripotent stem cell (iPS) technique.
Researchers at Johns Hopkins have discovered that the Notch protein helps human embryonic stem cells "decide" their own fate, a finding which may eventually be useful in programming cells for the development of stem cell therapies. Their results are reported in the May 2008 issue of Cell Stem Cell.
Kansas State University researchers are working on a method of delivering cancer drugs that promises to be more efficient and reduce the side effects patients have to deal with.
Researchers at the Joslin Diabetes Center have demonstrated for the first time that transplanted muscle stem cells can both improve muscle function in animals with a form of muscular dystrophy and replenish the stem cell population for use in the repair of future muscle injuries.
A gene that is overexpressed in 20 percent of breast cancers increases the number of cancer stem cells, the cells that fuel a tumor's growth and spread, according to a new study from the University of Michigan Comprehensive Cancer Center.
Researchers have shown that they can put mouse embryonic stem cells to work building the heart, potentially moving medical science a significant step closer to a new generation of heart disease treatments that use human stem cells.
In recent years, stem cell researchers have become very adept at manipulating the fate of adult stem cells cultured in the lab. Now, researchers at the Salk Institute for Biological Studies achieved the same feat with adult neural stem cells still in place in the brain. They successfully coaxed mouse brain stem cells bound to join the neuronal network to differentiate into support cells instead.
Burnham Scientists have genetically programmed embryonic stem cells to become nerve cells when transplanted into the brain. The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells.
Adult stem cells improve healing of broken bones and could eventually serve as a new treatment for the 10 to 20 percent of fractures that fail to heal, according to a new study. The results will be presented Monday, June 16, at The Endocrine Society's 90th Annual Meeting in San Francisco, by Froilan Granero-Molto, PhD, research associate of the University of North Carolina.
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