Feature Channels: Stem Cells

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The University of Texas MD Anderson Cancer Center and Affimed N.V., a clinical stage biopharmaceutical company focused on discovering and developing highly targeted cancer immunotherapies, today announced an exclusive strategic clinical development and commercialization collaboration to evaluate Affimed’s TandAb technology in combination with MD Anderson’s natural killer cell (NK) product.

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Researchers have developed a synthetic version of a cardiac stem cell. These synthetic stem cells offer therapeutic benefits comparable to those from natural stem cells and could reduce some of the risks associated with stem cell therapies.

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Using human embryonic stem cells to create a type of cardiac cells known as sinotrial (SA) node pacemaker cells, researchers have developed a biological pacemaker that overcomes many of the limitations of electrical pacemakers.

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Researchers at the University of Maryland School of Medicine (UM SOM) and the Interdisciplinary Stem Cell Institute (ISCI) at the University of Miami Miller School of Medicine have begun testing to see whether adult stem cells derived from bone marrow benefit children with the congenital heart defect hypoplastic left heart syndrome (HLHS).

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Miqin Zhang, a professor of materials science and engineering at the University of Washington, is looking for ways to help the body heal itself when injury, disease or surgery cause large-scale damage to one type of tissue in particular: skeletal muscle.

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Denis Evseenko, MD, PhD, of Keck Medicine of USC receives a $2.5 million grant from CIRM to develop an off-the-shelf therapy for osteoarthritis. Osteoarthritis affects tens of millions of Americans, with that number expected to grow exponentially due to obesity and longer lifespans.

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Delivery of stem cells to damaged tooth roots using a collagen-derived biomaterial is effective at regenerating dental pulp-like tissue and shows promise as a potential therapy for restoring natural tooth function in a rodent model.

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A ‘living bandage’ made from stem cells, which could revolutionise the treatment and prognosis of a common sporting knee injury, has been trialled in humans for the first time by scientists at the Universities of Liverpool and Bristol.

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In a Cancer Research paper, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

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Johns Hopkins scientists report success in using a cocktail of cell-signaling chemicals to further wind back the biological clock of human embryonic stem cells (ESCs), giving the cells the same flexibility researchers have prized in mice ESCs.

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Scientists from the McEwen Centre for Regenerative Medicine, University Health Network, have developed the first functional pacemaker cells from human stem cells, paving the way for alternate, biological pacemaker therapy.

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A team of scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) discovered a new bone-forming growth factor, Osteolectin (Clec11a), which reverses osteoporosis in mice and has implications for regenerative medicine.

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Blood-forming stem cells are able to count and store memories of the number of times that they divide, findings which could have major implications for disease research, scientists at the Icahn School of Medicine at Mount Sinai have found.

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A team of scientists has uncovered details of the cellular mechanisms that control the direct programming of stem cells into motor neurons.

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Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.

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The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells’ offspring have found their station and purpose in the body. Their decisions are guided in part by TET proteins rewriting the epigenome, the regulatory layer of chemical flags that adorn the genome and influence gene activity, report researchers at La Jolla Institute for Allergy and Immunology and UC San Diego.

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Researchers from the Cedars-Sinai Heart Institute and the Cedars-Sinai Department of Medicine are expanding their ongoing evaluation of a novel cell-based therapeutic candidate into the area of pulmonary arterial hypertension (PAH). This work will be supported by a recently-awarded $7.3 million grant from the California Institute for Regenerative Medicine.

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Fred Hutchinson Cancer Research Center announced promising results from an early trial in which patients with high-risk acute myeloid leukemia received genetically engineered immune cells. Of the 12 AML patients who received this experimental T-cell therapy after a transplant put their disease in remission, all are still in remission after a median follow-up of more than two years.

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Researchers at the University of Wisconsin-Madison have developed a novel strategy to reprogram cells from one type to another in a more efficient and less biased manner than previous methods.

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The Mayo Clinic Center for Regenerative Medicine is a co-sponsor of the 2016 World Stem Cell Summit. More than 1,200 attendees are expected at the 12th annual event in West Palm Beach, Florida.