Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibility.
A review of previously published research suggests that stem cells harvested from an adult's blood or marrow may provide treatment benefit to select patients for some autoimmune diseases and cardiovascular disorders, according to an article in the February 27 issue of JAMA.
For the first time, researchers have used embryonic stem cells to develop functioning immune system blood cells -- an important step in eventually using embryonic stem cells as an alternative source of cells for traditional bone marrow transplantations.
Using embryonic stem cells from mice, UT Southwestern Medical Center researchers have prompted the growth of healthy "“ and more importantly, functioning "“ muscle cells in mice afflicted with a human model of Duchenne muscular dystrophy.
Stem cells -- popularly known as a source of biological rejuvenation -- may play harmful roles in the body, specifically in the growth and spread of cancer. Amongst the wildly dividing cells of a tumor, scientists have located cancer stem cells. Physician-scientists from Weill Cornell Medical College are studying these cells with hopes of combating malignant cancers in the brain.
The VCU Life Sciences Survey is the first poll to reflect the discovery reported internationally in November that human skin cells can be used to create stem cells or their near equivalents.
Researchers have discovered a key molecular switch that regulates cancer stem cells. This switch, which belongs to a class of molecules called microRNAs, can decrease a cancer stem cell's ability to propagate tumors.
Researchers at UAB and Whitehead Institute report correcting the basic genetic mutation in mouse models of sickle cell anemia through use of induced pluripotent stem cells, iPS cells.
A stem cells' immediate neighborhood, a specialized environment also known as the stem cell niche, provides crucial support needed for stem cell maintenance. But nothing lasts forever, found scientists at the Salk Institute for Biological Studies. During the aging process, the level of support drops off, diminishing the stem cells' ability to replenish themselves (self-renew) indefinitely.
Patients living with Myasthenia Gravis (MG) may breathe easier thanks to a rare bone marrow transplant procedure performed at The Bone Marrow Transplant Program at University of California, San Diego Medical Center, the only program in the western United States that has attempted this procedure.
At the 2007 Annual Meeting of the American Association for Cancer Research, researchers present new discoveries about stem cells in leukemia, breast and colon cancer that add to the growing evidence that perhaps cancer is, fundamentally, a stem cell problem.
Studies presented at the 2007 meeting of the American Association for Cancer Research show how researchers are using the new, as well as the natural, to help design and test new drugs to treat cancer.
A therapy that includes stem cell transplantation induced extended insulin independence in patients with type 1 diabetes mellitus, according to a preliminary study in the April 11 issue of JAMA.
University of Utah geneticists have engineered mice that can develop synovial sarcoma "“ a significant early step toward developing new treatments for the aggressive, deadly cancer that most often kills teenagers and young adults. The mice were used to determine that synovial sarcoma develops in muscle cell precursors known as myoblasts, the researchers report in the journal Cancer Cell.
Heart attack patients who received an new intravenous adult stem cell therapy, Provacelâ„¢, experienced a lower number of adverse events, such as cardiac arrhythmias, and had significant improvements in heart, lung and global function compared to those who received a placebo, according to six-month Phase I study data presented at the American College of Cardiology's Innovation in Intervention: i2Summit in New Orleans on March 25.
A newly discovered small molecule called IQ-1 plays a key role in preventing embryonic stem cells from differentiating into one or more specific cell types, allowing them to instead continue growing and dividing indefinitely, according to research performed by a team of scientists who have recently joined the stem-cell research efforts at the Keck School of Medicine of the University of Southern California.
The discovery that bone-marrow derived stem cells can regenerate damaged renal cells in an animal model of Alport syndrome provides a potential new strategy for managing this inherited kidney disease and offers the first example of how stem cells may be useful in repairing basement membrane matrix defects and restoring organ function.
Researchers at the University of Illinois at Chicago have been awarded $2 million to establish a Center for the Development of Stem Cell Therapies for Human Diseases.
Scientists uncover signatures near crucial developmental genes; analysis provides framework for understanding cells' unusual plasticity.
Scientists have uncovered new information about what orchestrates the complex balance between blood stem cells and mature blood cells, a relationship that is often disrupted in leukemia. The results will lead to a better understanding of the behavior of leukemic cells.
Liquid crystals, the same phase-shifting materials used to display information on cell phones, monitors and other electronic equipment, can also be used to report in real time on the differentiation of embryonic stem cells.
Therapy that involved bone marrow stem cells did not improve cardiac function in patients following a heart attack, according to a study.
A study has provided the first comprehensive map of a part of the adult human brain containing astrocytes, cells known to produce growth factors critical to the regeneration of damaged neural tissue and that potentially serve as brain stem cells.
A new study published this week in the Proceedings of the National Academy of Sciences online Early Edition provides compelling visual evidence that hematopoietic, or blood-forming, stem cells prefer a solitary life.
Whitehead Institute scientists have found that the same protein that causes neurodegenerative conditions such as bovine spongiform encephalopathy (mad cow disease) is also important for helping certain adult stem cells maintain themselves.
New study may lead to improved stem cell therapies for patients with compromised immune systems due to intensive cancer therapy or autoimmune disease. Researchers found that the sympathetic nervous system plays a critical role in coaxing bone marrow stem cells into the bloodstream.
Researchers in the lab of Whitehead Institute Member and MIT professor of biology Harvey Lodish have discovered a way to multiply an adult stem cell 30-fold, an expansion that offers tremendous promise for treatments such as bone marrow transplants and perhaps even gene therapy.
Analyzing the complete gene-expression profiles of both cloned and fertilization-derived stem cells in mice, scientists at Whitehead Institute for Biomedical Research now have concluded that the two are indistinguishable.
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