Curated News: NEJM

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Released: 7-Jan-2019 9:50 AM EST
Opioids Fueled a Doubling of Suicides and Overdoses in the U.S.
Michigan Medicine - University of Michigan

Suicides and drug overdoses kill American adults at twice the rate today as they did just 17 years ago, and opioids are a key contributor to that rise, according to a new review and analysis. Reversing this deadly double trend will take investment in programs that have been proven to prevent and treat opioid addiction, the researchers say.

21-Dec-2018 10:05 AM EST
For Patients with Kidney Disease, Genetic Testing May Soon Be Routine
Columbia University Irving Medical Center

DNA sequencing can be used to identify the underlying genetic cause of many rare types of chronic kidney disease, leading to better treatment, finds a new study from Columbia University.

14-Dec-2018 11:05 AM EST
Targeted Treatment Slows Progression of Rare Connective Tissue Tumor
Columbia University Irving Medical Center

About 80 percent of patients with desmoid tumors had no progression of their tumors over a two-year period while taking a drug called sorafenib during a phase 3 clinical trial.

14-Dec-2018 1:05 PM EST
How Children & Teens Die in America: Study Reveals the Widespread & Persistent Role of Firearms
Michigan Medicine - University of Michigan

America lost 20,360 children and teens in 2016 -- 60 percent of them to preventable injuries, a new study shows. But while death rates from the top cause – motor vehicle crashes – have declined steadily since 1999, rates from the second-leading cause - firearms - have gone up. It’s the first time all causes of child and adolescent death have been tallied by both mechanism and intent.

5-Dec-2018 8:05 PM EST
15 percent of babies exposed to Zika before birth had severe abnormalities in first 18 months of life
University of California, Los Angeles (UCLA), Health Sciences

By age 12 to 18 months, 6.25% of children exposed to Zika during their mothers’ pregnancies had eye abnormalities, 12.2% had hearing problems, and 11.7% had severe delays in language, motor skills and/or cognitive function. In all, 14.5% had at least one of the three abnormalities.

30-Nov-2018 8:30 AM EST
Global Trial Shows CAR T Therapy Can Lead to Durable Remissions in Non-Hodgkin’s Lymphoma
Perelman School of Medicine at the University of Pennsylvania

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

30-Nov-2018 4:00 PM EST
CAR-T cell update: therapy improves outcomes for patients with B-cell lymphoma
University of Chicago Medical Center

An international phase-2 trial of a CAR-T cell therapy—to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)—found that 52% of patients responded favorably to the therapy; 40% had a complete response and 12% had a partial response. One year later, 65% of those patients were relapse-free, including 79% of complete responders. The median progression-free survival “has not been reached.”

29-Nov-2018 1:00 PM EST
Sickle Cell Anemia Treatment Safely Lowers Disease Burden in African Children
Cincinnati Children's Hospital Medical Center

A daily hydroxyurea pill may bring relief for children living with the painful and deadly blood disease sickle cell anemia (SCA) in resource-challenged sub-Saharan Africa, where the disease is prevalent and health care is suboptimal. This is what a multinational clinical trial called REACH discovered when it tested daily hydroxyurea treatment in 606 children between the ages of 1 and 10 years old. Study data are published in the New England Journal of Medicine.

26-Nov-2018 3:35 PM EST
Children Who Start School a Year Early More Likely to Be Diagnosed with ADHD, Study Shows
Harvard Medical School

Children who enter elementary school younger than their peers are more likely to be diagnosed with ADHD. Children born in August in states with a Sept. 1 cutoff birth date for school enrollment have a 30 percent higher risk for ADHD diagnosis than peers born in September, which may reflect over-diagnosis.

16-Nov-2018 1:40 PM EST
Probiotics no help to young kids with stomach virus
Washington University in St. Louis

A major U.S. study led by Washington University School of Medicine in St. Louis found that a commonly used probiotic is not effective in improving symptoms of diarrhea and vomiting in young children with gastroenteritis.

20-Nov-2018 3:30 PM EST
Probiotic No Better Than Placebo for Acute Gastroenteritis in Children
Ann and Robert H. Lurie Children's Hospital of Chicago

While probiotics are often used to treat acute gastroenteritis (also known as infectious diarrhea) in children, the latest evidence shows no significant differences in outcomes, compared to a placebo.

Released: 20-Nov-2018 10:50 AM EST
Peanut Allergy Immunotherapy Shows Positive Results in Phase 3 Trial
Ann and Robert H. Lurie Children's Hospital of Chicago

About a year after receiving daily oral immunotherapy for severe peanut allergy, 67 percent of children in a Phase 3 trial were able to tolerate eating at least two peanuts (600 mg) without an allergic reaction, while 50 percent tolerated eating three to four peanuts (1,000 mg) without symptoms. At the start of the study, all of these children had allergic reactions after ingesting just 1/10 of a peanut (30 mg). These results of an international, randomized, double-blind, placebo-controlled trial conducted at 66 sites, including Ann & Robert H. Lurie Children’s Hospital of Chicago, were published in the New England Journal of Medicine.

Released: 19-Nov-2018 11:05 AM EST
Researchers find promise in new treatment for peanut allergy
University of Chicago Medical Center

Controlled ingestion of peanut protein could help build tolerance in peanut allergy sufferers. Authors of a new study published in the New England Journal of Medicine say an oral immunotherapy drug they tested could be the first FDA-approved medication of its kind for people with peanut allergy. The medication, called AR101, is derived from peanut protein.

Released: 19-Nov-2018 8:00 AM EST
Media Advisory: Look to Social Aspects of Health Not Just Biology, Say Researchers
Johns Hopkins Medicine

It’s a common scenario in many emergency rooms: A man with a long history of homelessness and schizophrenia reports hallucinations and thoughts of suicide. Should the medical team admit him for hospitalization or treat him with antipsychotic drugs and release him from the ER? Lessons learned from this experience are the focus of the first article in a series of case studies that begins Nov. 15 in the New England Journal of Medicine.

13-Nov-2018 12:00 PM EST
New Treatment to Protect People with Peanut Allergies ready for FDA Review
American College of Allergy, Asthma and Immunology (ACAAI)

Final research results for a new treatment for protection against accidental exposure to peanut were presented today at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting and published in the New England Journal of Medicine.

Released: 8-Nov-2018 4:05 PM EST
Oral Antibiotic Treatment Option for Gonorrhea Identified by UAB Researchers
University of Alabama at Birmingham

Scientists have found that a single-dose of the oral antibiotic zoliflodacin successfully treated uncomplicated genital infections caused by gonorrhea, according to research published in The New England Journal of Medicine.

Released: 8-Nov-2018 11:05 AM EST
Case Western Reserve-Led Study Triggers Change in WHO Guidelines for Treating Lymphatic Filariasis, Now Targeted for Elimination
Case Western Reserve University

Researchers from Case Western Reserve University School of Medicine have shown that a single “cocktail” of three pill-based anti-parasite medications is significantly more effective at killing microscopic larval worms in people diagnosed with lymphatic filariasis, commonly known as elephantiasis, than other standard two-drug combinations previously used in the global effort to eliminate this infectious disease. A combination of all three drugs given simultaneously had never been tested until now. An estimated 120 million people in over 50 tropical and subtropical countries are infected with lymphatic filariasis and another 856 million people are at risk.

Released: 6-Nov-2018 10:05 AM EST
New Checkpoint Inhibitor Shows Promise in Clinical Trial for Non-Hodgkin’s Lymphoma
University of Chicago Medical Center

By combining the experimental anti-cancer antibody known as 5F9 with the anti-cancer antibody rituximab, researchers managing a phase 1b clinical trial were able to induce a positive response in 11 out of 22 people with relapsed/refractory non-Hodgkin’s lymphoma. Eight of the 22 patients went into complete remission from their cancers.

Released: 1-Nov-2018 12:10 PM EDT
Cluster of Cocaine-Fentanyl Overdoses in Philadelphia Underscores Need for More “Test Strips” and Rapid Response
Perelman School of Medicine at the University of Pennsylvania

Penn Medicine emergency department physicians are calling for more readily available testing strips to identify the presence of fentanyl in patients experiencing a drug overdose, and a rapid, coordinated response among health care providers and city agencies to help curb overdoses and identify high potency high risk drugs.

30-Oct-2018 10:05 AM EDT
For Early Cervical Cancer, Open Hysterectomy is Safer than Minimally Invasive Surgery
Columbia University Irving Medical Center

A new study found that women with cervical cancer who had a radical hysterectomy with minimally invasive surgery had a significantly higher risk of death than those who had open surgery.



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