In a new study, researchers from the Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease. This insight, they say, reveals the mechanism for how prions can jump between some animal species, while retaining a transmissibility barrier between other species.
Case Western Reserve University in Cleveland, Ohio, ranks No. 21 globally for the number of U.S. Utility Patents awarded to the university and its researchers, according to 2021 data compiled by the U.S. Patent and Trademark Office (USPTO).
Research led by Case Western Reserve University has identified a promising path to developing therapies to treat esophageal tumors––a form of cancer that not only is among the most deadly, but also has been occurring at increasing rates over the past decade.
The research arm of the U. S. Army has awarded Case Western Reserve University blood surrogate pioneer Anirban Sen Gupta a four-year, $2.5 million grant to advance and optimize his latest nanotechnology to stop bleeding from battlefield injuries.
The new technology devised by Sen Gupta and his team is called “SanguiStop.” It allows a clot-promoting enzyme called thrombin to be intravenously delivered in a targeted manner to a bleeding area—especially to the site of internal injuries.
Older physicians benefit from their many years of experience and the skills they have developed over decades of practice. At the same time, they may be at risk of cognitive decline, raising concerns about job performance deficits.
Leading researchers will gather this week at a Case Western Reserve University-led symposium highlighting progress and opportunities in biomedical research and human-performance sciences.
The event takes place this Thursday and Friday, Aug. 18-19, at the Wolstein Research Center on the Case Western Reserve campus, and features researchers and clinicians from the university, area hospital affiliates and the Wright-Patterson Air Force Base in Dayton.
The new five-year, $500,000 grant will support Ayday’s ongoing work to identify, analyze and mitigate privacy vulnerabilities for individuals who share their genomic information with institutions, which then share the data with wider genomic databases.
Personal genomic data refers to each person’s unique genome, his or her genetic makeup and information that can be gleaned from DNA analysis of a blood test or saliva sample.
A team of researchers at the Case Western Reserve University School of Medicine and Case Comprehensive Cancer Center believe they have identified a cell signaling pathway responsible for the development of esophageal adenocarcinomas, an aggressive form of esophageal cancer that has gradually become more common, even in younger people.
Neutrophils are a type of white blood cell that helps fight illness and disease by traveling to the body’s infected site to seek and destroy harmful pathogens.
Following numerous atrocities in Ukraine, a team of international law experts is offering a proposal for a special court in Ukraine to investigate and prosecute those responsible.
New research from the Case Western Reserve University School of Medicine brings into focus how prions might be formed and how they affect health outcomes.
Researchers at Case Western Reserve University have created a simple prototype device that enables users to control “smart home” technology by changing their breathing patterns.
The self-powered unit fits into the nostrils and has the potential to enhance the quality of life for people with limited mobility or inability to speak clearly. It also can be programmed provide automatic alerts to medical personnel if an individual has trouble breathing.
Researchers at the Case Western Reserve University School of Dental Medicine will use a $3.25 million grant from the National Institutes of Health (NIH) to better understand how HIV impacts the human body, from mouth lesions to oral cancer.
Aresearch team is testing a protein block to suppress specific cells of the body’s immune system contribute to developing type 1 diabetes. If successful, the drug would diminish autoimmunity, preserving the body’s ability to naturally produce more insulin, the researchers said.
Researchers at Case Western Reserve University and the University of Washington expect to gain valuable new insights into highly aggressive prostate cancer by combining Artificial Intelligence (AI)-powered diagnostic imaging with three-dimensional (3D) tissue imaging.
The study found that Omicron-specific antibodies reached detectable levels in 86% of nursing home residents and 93% of healthcare workers after receiving the booster shot, compared to just 28% of nursing home residents and healthcare workers after the initial two-dose COVID-19 vaccine series.
The U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) recently awarded a combined $2.08 million to seven organizations in six states to develop “manufacturing technology roadmaps.”
Case Western Reserve University has signed an exclusive license agreement with Picture Health that aims to turn the promise of AI tools into a reality that ultimately benefits patients around the globe.
Breakthrough COVID-19 cases resulting in infections, hospitalizations and deaths are significantly more likely in cancer and Alzheimer’s patients, according to two new studies from researchers at the Case Western Reserve University School of Medicine.
The condition, known as hypoxic-ischemic encephalopathy (HIE), can result in severe brain damage, which is why researchers at the Case Western Reserve University School of Medicine and UH Rainbow Babies & Children's Hospital (UH Rainbow) are studying the condition to evaluate how HIE is treated and develop new, more effective options.
Researchers at the Case Western Reserve University School Medicine have found that combining two cancer drugs can be effective in treating a specific type of colorectal cancer, according to a new study published in Nature Communications.
Cancer researchers at the Case Western Reserve University School of Medicine say they have successfully suppressed the growth of some solid tumors in research models by manipulating immune cells known as a macrophages.
About 5,000 children and teens in the United States are diagnosed with type 2 diabetes each year, and the rate is increasing about 5% annually, putting thousands of children at risk for diabetic kidney disease (DKD). While DKD is still considered relatively rare in children, Katherine Kutney, an assistant professor of pediatrics at Case Western Reserve University, expects cases to increase from pandemic-induced obesity—the lack of physical activity, more time spent stationary in front of computer screens. But DKD in children may be slowed with medication therapy if signs of the disease can be detected early and monitored—the goal of new research Kutney will pursue with a 2021 Hartwell Individual Biomedical Research Award.
A new study from Case Western Reserve University suggests a key protein molecule plays a major role in the accumulation of brain cholesterol, triggering the development of Alzheimer’s and supporting the use of peptide inhibitors as a therapeutic treatment target. The study found that mice, when treated with the peptide inhibitor, demonstrated 50% restored memory function, based on testing such as navigating mazes.
New research from the Case Western Reserve University (CWRU) School of Medicine suggests that the children younger than age 5 who are infected with the COVID-19 Omicron variant have less risk of severe health outcomes than those infected with the Delta variant.
Stanton Gerson, dean and senior vice president for medical affairs at the Case Western Reserve University (CWRU) School of Medicine, has appointed Daniel Simon senior associate dean for academic affairs for University Hospitals (UH).
With$1.7 million in support from the U.S. Department of Energy (DOE) and the Critical Materials Institute, scientists at Case Western Reserve University in Cleveland, Ohio, are developing a high-temperature electrochemical process to convert rare earth minerals like neodymium into highly sought-after metals for clean-energy applications.
Scientists at Case Western Reserve University have developed an inexpensive way to transform an ordinary shirt into an electronic smart shirt—one able to monitor and adjust body temperature or even allow the wearer to apply heat to a sore shoulder or back. All from a design printed on the fabric of the shirt or any other piece of clothing.
An international team led by the Case Western Reserve University School of Medicine has discovered novel properties of the protein Gasdermin B that promotes repair of cells lining the gastrointestinal tract in people with chronic inflammatory disorders like Crohn’s disease and ulcerative colitis.
Case Western Reserve University announced today that alumnus Joel Roth has committed more than $20 million to support a leadership institute designed to prepare students to address the increasingly complex challenges facing the globe.
The tall tale of the “steel-driving man” inspired songs, books and films—and, now, new research from Case Western Reserve University about the health effects of John Henryism.
A Case Western Reserve dental school researcher was awarded $3.7M in NIH grants to study the link between people living with HIV and higher rates of cancer and other diseases.
Case Western Reserve University School of Medicine Professor Neil Greenspan has been named a fellow of the American Association for the Advancement of Science (AAAS), an honor bestowed upon AAAS members by their peers for their “scientifically or socially distinguished efforts to advance science or its applications.”
Case Western Reserve University and Ionis Pharmaceuticals, Inc. have signed an exclusive license agreement to advance and commercialize a therapeutic approach discovered by university medical researchers to treat Pelizaeus-Merzbacher disease (PMD).
The Inamori International Center for Ethics and Excellence at Case Western Reserve University will award Paul Farmer, a physician and medical anthropologist who has dedicated his life to improving healthcare for the world's most in need, with the 2022 Inamori Ethics Prize.
A new study by researchers at the Case Western Reserve University School of Medicine finds those who received the Moderna COVID-19 mRNA vaccine are less likely to experience “breakthrough” COVID-19 cases, compared to recipients of the Pfizer-BioNTech mRNA vaccine.
Researchers from Case Western Reserve University have identified a new mechanism by which a protein known for repairing damaged DNA also protects the integrity of DNA by preserving its structural shape. The discovery, involving the protein 53BP1, offers insight into understanding how cells maintain the integrity of DNA in the nucleus, which is critical for preventing diseases like premature aging and cancer.
When Cleveland City Council passed the Lead Safe Cleveland ordinance in 2019—landmark legislation resulting from data showing the toxic heavy metal was poisoning the city’s youth at alarming rate—a team of researchers from Case Western Reserve University was tasked with tracking and evaluating the initiative’s progress.
Results of a new study by researchers at Case Western Reserve University represent a step toward improving our understanding of Crohn’s disease and the factors that cause its intestinal inflammation.
A Northeast Ohio student-founded company developing inexpensive, acoustically solid, and durable 3D-printed ¼-size violins for children’s use will show off their latest iteration at CES 2022 in January.
A Case Western Reserve University engineer will lead a team of scientists helping NASA and other agencies plan for the future refueling of spacecraft while in space.
More than 250 researchers across nearly two dozen research groups—from computer science to materials science to robotics will benefit from the faster and larger computing power of a new “Artificial Intelligence SuperComputer” (AISC) at Case Western Reserve University. The nearly $1 million computer system, expected to be installed and in use by summer 2022, is the university’s largest and far more powerful than anything university researchers had access to before.
Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have used artificial intelligence (AI) to identify patterns on computed tomography (CT) scans that offer new promise for treating patients with small cell lung cancer. Small cell lung cancer (SCLC) represents about 13% of all lung cancers, but grows faster and is more likely to spread than non-small cell lung cancer, according to the American Cancer Society.