A solitary cell containing a unique abnormality can result in certain types of blood cancers known as myeloproliferative neoplasms (MPN), according to researchers in Switzerland. The results open new opportunities to examine single mutant cells and follow tumor initiation and progression of human MPN cancers.
Scientists have found a way to find the proverbial needle in the cancer antigen haystack. The results have the potential to completely change current approaches to generating anticancer vaccines.
Leaky intestines may cripple bacteria-fighting immune cells in patients with common variable immunodeficiency (CVID), a rare hereditary disease. The study may explain why these patients suffer from recurrent bacterial infections.
A single protein may tip the balance between ridding the body of a dangerous hepatitis virus and enduring life-long chronic infection, according to researchers in Germany.
Two studies from Christopher Miller's lab at Brandeis University provide new insights into the mechanisms that allow bacteria to resist fluoride toxicity, information that could eventually help inform new strategies for treating harmful bacterial diseases.
Through the deep-Indexing of journals, ReadCube Discover makes RUP’s content more accessible and easier to find across ReadCube’s web, desktop, and mobile reading portals, plus search engines and recommendation feeds.
Researchers reveal how the alteration of a single nucleotide—the basic building block of DNA—could initiate fragile X syndrome, the most common inherited form of intellectual disability.
A study in JCB provides further detail into how male fruit flies deploy exosomes to alter the mating behavior of females. The findings also identify a signaling pathway that might play a role in human cancers of tissues that secrete exosomes, such as the prostate and breast.
Reserachers show that a specialized subset of lung cells can shake flu infection, yet they remain stamped with an inflammatory gene signature that wreaks havoc in the lung.
Researchers reveal how a lung-damaging bacterium turns the body's antibody response in its favor.
Researchers uncover a new drug that spurs liver regeneration after surgery.
Crafty parasites undergo dramatic shape changes that enable them to adapt to different living conditions and thrive. Researchers show that these transformations might not be as difficult as they appear.
A diet enriched in 18-HEPE might help prevent heart failure in patients with cardiovascular diseases, according to researchers in Japan.
Unclogging the body’s protein disposal system may improve memory in patients with Alzheimer’s disease, according to researchers in Korea.
A new study provides the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan, potentially providing the key that will enable researchers to unlock their therapeutic potential.
Before it can fertilize an egg, a sperm has to bind to and bore through an outer egg layer known as the zona pellucida. Researchers now identify the protein in the zona pellucida that sperm latch onto.
Follicular lymphoma is an incurable form of non-Hodgkin lymphoma that is diagnosed each year in 120,000 people worldwide. Researchers show that a high-risk group of patients with the disease could benefit from a novel drug combination.
Researchers reveal that neurons can utilize a supremely localized internal store of calcium to initiate the secretion of neuropeptides, one class of signaling molecules through which neurons communicate with each other and with other cells.
The venom from marine cone snails, used to immobilize prey, contains numerous peptides called conotoxins, some of which can act as painkillers in mammals. Researchers provide new insight into the mechanisms by which one conotoxin, Vc1.1, inhibits pain.
Researchers describe how aspirin acts on key skin cells called keratinocytes to delay skin repair at wound sites. A better understanding of this process offers hope for the development of drugs to encourage wounds to heal.
Researchers show that IKKβ functions in smooth muscle cells to regulate vascular inflammatory responses and atherosclerosis development in mice. Surprisingly, the lack of IKKβ also protects the animals from diet-induced obesity. The use of IKKβ inhibitors may provide an innovative treatment for atherosclerosis, obesity, and metabolic disorders.
In addition to its role as a sodium and potassium ion transporter, the ubiquitous sodium pump displays “hybrid” function by simultaneously importing protons into the cell. Proton inflow might play a role in certain pathologies, including heart attack and stroke.
The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells. Sometimes oncogenes manage to initiate tumor development in the presence of p53, which focuses its efforts instead on limiting the tumor’s ability to invade and metastasize. Researchers uncover one way that p53 acts to prevent cancer cell invasion.
The process of producing high-quality, fertile sperm requires many steps. Researchers show the transcription factor p73 promotes this process by regulating the adhesions between developing sperm and their support cells.
It is not only genetics that predispose to bowel cancer; microbes living in the gut help drive the development of intestinal tumors, according to new research in mice.
Cancer cells have long been known to have higher rates of the energy-generating metabolic pathway known as glycolysis. This enhanced glycolysis is thought to allow cancer cells to survive the oxygen-deficient conditions they experience in the center of solid tumors. Researchers reveal how damaged cells normally switch off glycolysis as they shut down and show that defects in this process may contribute to the early stages of tumor development.
Researchers show that a novel two-pronged strategy targeting DNA synthesis can treat leukemia in mice while sparing damage to normal blood cells.
Various muscular diseases are associated with changes in the elasticity of the protein titin, but whether these changes are a cause or an effect of disease has been unclear. Researchers help solve this “chicken or the egg” conundrum and identify a key player in determining titin’s size and stiffness.
Kinesins are motor proteins that “walk” along microtubules and transport various cargoes throughout the cell. Researchers uncover an unexpected role for one kinesin in the pathway that regulates cholesterol levels in the blood.
The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. Researchers provide new insight into the molecular pathway underlying this process.
The JCB DataViewer archives data for authors and makes those data available for viewing, query, and re-use by other scientists. It has been under continuous development to support new image data formats and to provide new functionality for its users, including the hosting of extremely large images.
Cancer cells have something that every prisoner longs for—a master key that allows them to escape. A new study describes how a protein that promotes tumor growth also enables cancer cells to use this key and metastasize.
Study helps explain how nicotine exploits the body’s cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.
Using a new technique to evaluate working muscles in mice, researchers have uncovered physiological mechanisms that could lead to new strategies for combating metabolism-related disorders like muscle wasting and obesity.
The study identifies a common, early marker of senescent cells that could have important implications for tumor suppression and aging-related diseases like Progeria
RNA molecules are generally thought to be “silent” when stowed in cytoplasmic granules. But a protein mutated in some ALS patients forms granules that permit translation of stored RNAs. The finding identifies a new mechanism that could contribute to the pathology of the disease.
A novel immune-boosting drug combination eradicates an aggressive form of brain cancer in mice, according to a study in The Journal of Experimental Medicine.
Most people have experienced the effects of circadian-rhythm disruption. To have any hope of modulating our biological “clocks,” we need to first understand the physiology at play. A new JGP study helps explain some of the biophysical processes underlying regulation of circadian rhythms.
Our ability to hear relies on hair cells, sensory receptors that mechanically amplify low-level sound that enters the inner ear through a transduction channel. A new study in The Journal of General Physiology could help lead to a definitive identification of this mystery channel.
Two gene alterations pair up to promote the growth of leukemia cells and their escape from anti-cancer drugs.
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers.
A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology.
A new book presents the in-depth story about the men and women who created a new science, modern cell biology.
Synapse development is promoted by a variety of cell adhesion molecules that connect neurons and organize synaptic proteins. Many of these adhesion molecules are linked to neurodevelopmental disorders; mutations in neuroligin and neurexin proteins, for example, are associated with autism and schizophrenia. According to a study in The Journal of Cell Biology, another family of proteins linked to these disorders regulates the function of neuroligins and neurexins in order to suppress the development of inhibitory synapses.
Researchers used induced pluripotent stem cells (iPSCs) derived from a young patient with Long QT syndrome (LQTS), a congenital heart disorder, to determine a course of treatment that helped manage the patient’s life-threatening arrhythmias.
Failure to launch an adequate immune response may be at the root of septic shock, according to a study published in The Journal of Experimental Medicine on December 17th.
The orientation of antibody binding to bacteria can mean life or death to the bug, according to a study published in The Journal of Experimental Medicine. These findings may help explain why these bacteria cause millions of localized infections, but more serious, systemic blood infections are rare.
A JCB study shows how a transcription factor called STAT3 remains in the axon of nerve cells to help prevent neurodegeneration. The findings could pave the way for future drug therapies to slow nerve damage in patients with neurodegenerative diseases.
A new study in JEM may provide a powerful new way to reduce relapses in people who have quit smoking or chewing tobacco.
A study in The Journal of Cell Biology identifies a motor protein that ferries HIV to the plasma membrane, helping the virus escape from macrophages
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