SOX10 Expression Levels may be a Critical Mediator of White Matter Dysfunction in Schizophrenia
PreprintsDonna L McPhie, Boyu Ren, Juan Antonio Garcıa-Leon, Catherine M Verfaillie, Bruce M Cohen
Feature Channels: Stem Cells
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Released: 17-Jun-2022 12:00 PM EDT
Released: 17-Jun-2022 12:00 PM EDT
AKT1-FOXO4 Axis Regulates Hemochorial Placentation
PreprintsKeisuke Kozai, Ayelen Moreno Irusta, Khursheed Iqbal, Mae-Lan Winchester, Regan L Scott, Mikaela E Simon, Masanaga Muto, Marc R Parrish, Michael J Soares
Released: 17-Jun-2022 12:00 PM EDT
Daily administration of low-dose daunorubicin or doxorubicin inhibits hypoxia-inducible factor 1 and tumor vascularization
PreprintsYongkang Yang, David Z. Chen, Sergio Rey, Jun O. Liu, Gregg L. Semenza
Released: 17-Jun-2022 12:00 PM EDT
Inhibition of Fas Receptor Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis
PreprintsMehmet Kural, Umidahan Djakbarova, Bilal Cakir, Yoshiaki Tanaka, Yasaman Madraki, Hong Qian, Jinkyu Park, Lorenzo Sewanan, Comert Kural, Laura Niklason
Released: 17-Jun-2022 12:00 PM EDT
Rescue of aged muscle stem cell intrinsic quiescence defects by AKT inhibition revealed with a 3D biomimetic culture assay
PreprintsErik Jacques, Yinni Kuang, Allison P Kann, Robert S Krauss, Penney M Gilbert
Released: 17-Jun-2022 12:00 PM EDT
Alterations in protein kinase networks in astrocytes and neurons derived from patients with familial Alzheimers Disease
PreprintsNicholas Daniel Henkel, Alex Joyce, Elizabeth Shedroff, Ali Sajid Imami, Khaled Alganem, Abdul-Rizaq Hamoud, Chongchong Xu, Benjamin Siciliano, Tao Ma, Zhexing Wen, Robert Erne McCullumsmith
Released: 17-Jun-2022 12:00 PM EDT
Cell fusion upregulates PD-L1 expression and promotes tumor formation
PreprintsHisao Masai, Youichi Tajima, Futoshi Shibazaki
Released: 17-Jun-2022 12:00 PM EDT
Differentiation of intestinal epithelial stem cells from parthenogenetic embryonic stem cells
PreprintsZhiqiang Wang, Leilei Li, Wanpu Wang, Lilin Luo, Shuai Dong, Menglong Li, Tianxing Chen, Qingyang Meng, Rui Liang
Released: 17-Jun-2022 12:00 PM EDT
De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switch
PreprintsEvdokiia Potolitsyna, Sarah Hazell Pickering, Ave Tooming-Klunderud, Philippe Collas, Nolwenn Briand
Released: 17-Jun-2022 12:00 PM EDT
CITED2 Is A Conserved Regulator Of Deep Hemochorial Placentation
PreprintsMarija Kuna, Pramod Dhakal, Khursheed Iqbal, Esteban M. Dominguez, Lindsey N. Kent, Masanaga Muto, Ayelen Moreno-Irusta, Keisuke Kozai, Kaela M. Varberg, Hiroaki Okae, Takahiro Arima, Henry M. Sucov, Michael J. Soares
Released: 16-Jun-2022 1:30 PM EDT
New Solution for Stem Cell Manufacturing
University of Technology, SydneyResearchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.
Released: 16-Jun-2022 12:00 PM EDT
Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation
PreprintsJulianne N.P. Smith, Brittany A Cordova, Brian Richardson, Kelsey F Christo, Jordan Campanelli, Alyssia V Broncano, Jonathan Chen, Juyeun Lee, Scott J Cameron, Justin D Lathia, Wendy A Goodman, Mark J Cameron, Amar B Desai
Released: 16-Jun-2022 12:00 PM EDT
Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma
PreprintsLingli Gong, Ying Yin, Cheng Chen, Quan Wan, Die Xia, Mei Wang, Zhening Pu, Bo Zhang, Jian Zou
Released: 16-Jun-2022 12:00 PM EDT
Evaluation of targeted oxidative stress induced by oxygen-ozone gas mixtures in vitro after ischemic induction
PreprintsJéssica Rodrigues Orlandin, Sarah Ingrid Pinto Santos, Luciana Cristina Machado, Paulo Fantinato Neto, Fabiana Fernandes Bressan, Naira Caroline Godoy Pieri, Kaiana Recchia, Meline de Paula Coutinho, Priscilla Avelino Ferreira Pinto, Annalisa Santucci, Valter Travagli, Carlos Eduardo Ambrosio
Released: 16-Jun-2022 12:00 PM EDT
Autologous hematopoietic stem cell transplantation improves long term survival – data from a national registry
PreprintsNorbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser, Cord Sunderkoetter, Jörg H. W. Distler, Margitta Worm, Alexander Kreuter, Gernot Keyzer, Hanns-Martin Lorenz, Thomas Krieg, Nicolas Hunzelmann, Joerg Henes
Released: 16-Jun-2022 12:00 PM EDT
Comprehensive Characterisation of Fetal and Mature Retinal Cell Identity to Assess the Fidelity of Retinal Organoids
PreprintsHani Jieun Kim, Michelle Ohara-Wright, Daniel Kim, To Ha Loi, Benjamin Y Lim, Robyn V Jamieson, Anai Gonzalez Cordero, Pengyi Yang
Released: 16-Jun-2022 12:00 PM EDT
The Role of QRSL1 in Clinical Subtypes and Prognosis of Childhood B-cell Acute Lymphoblastic Leukemia
PreprintsSha Yin, Wenjin Gao, Ye Fan, Rui Xia, Mingyue Duan, Xi Zhang, Ansheng Liu, Yanmin Zhang
Released: 16-Jun-2022 12:00 PM EDT
Stagnation in quality of next-generation sequencing assays for the diagnosis of hereditary hematopoietic malignancies
PreprintsGregory W Roloff, Reid Shaw, Timothy E O'Connor, Michael W Drazer
Released: 15-Jun-2022 12:00 PM EDT
Transit-amplifying progenitor with maturation-dependent behavior contributes to epidermal renewal
PreprintsSangeeta Ghuwalewala, Kevin Jiang, Sara Ragi, David Shalloway, Tudorita Tumbar
Released: 15-Jun-2022 12:00 PM EDT
Accelerating effect of Shilajit on osteogenic property of adipose derived mesenchymal stem cells (ASCs)
PreprintsParisa Kangari, Leila Roshangar, Aida Iraji, Tahereh Talaei-Khozani, Mahboobeh Razmkhah
Released: 14-Jun-2022 2:05 PM EDT
Streamlining Stem Cells to Treat Macular Degeneration
École Polytechnique Fédérale de Lausanne (EPFL)As we age, so do our eyes; most commonly, this involves changes to our vision and new glasses, but there are more severe forms of age-related eye problems. One of these is age-related macular degeneration, which affects the macula — the back part of the eye that gives us sharp vision and the ability to distinguish details.
Released: 14-Jun-2022 12:00 PM EDT
Gla-domain mediated targeting of externalized phosphatidylserine for intracellular delivery
PreprintsTerry Hermiston, Jonathan Hardy, Maxine Bauzon, Francis G Blankenberg, Masamitsu Kanada, Ashley Makela, Charles K. F. Chan, Christopher H Contag
Released: 14-Jun-2022 12:00 PM EDT
The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition
PreprintsPei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang, Haibo Xiao
Released: 14-Jun-2022 12:00 PM EDT
Connexin43 Overexpression Promotes Bone Regeneration by Osteogenesis and Angiogenesis in Rat Glucocorticoid-Induced Osteonecrosis of the Femoral Head
PreprintsXin Zhao, Changjun Chen, Yue Luo, Donghai Li, Qiuru Wang, Yuying Fang, Pengde Kang
Released: 14-Jun-2022 12:00 PM EDT
Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
PreprintsJames A. Watson, Raphaël Pantier, Uma Jayachandran, Kashyap Chhatbar, Beatrice Alexander-Howden, Valdeko Kruusvee, Michal Prendecki, Adrian P Bird, Atlanta G. Cook
Released: 14-Jun-2022 12:00 PM EDT
Public Opinion About Stem Cell Research and Human Cloning - The Bioethics of Stem Cell Research and Therapy
PreprintsDaniel Cebo
Released: 14-Jun-2022 12:00 PM EDT
Comparative effects of retinoic acid, granulosa cells conditioned medium or forskolin in combination with granulosa cell co-culturing on mouse germ cell differentiation
PreprintsSoghra Bahmanpour, Zia Moasses, Nehleh Zareifard
Released: 13-Jun-2022 12:00 PM EDT
Stretchable mesh microelectronics for the biointegration and stimulation of neural organoids
PreprintsThomas L Li, Yuxin Liu, Csaba Forro, Levent Beker, Zhenan Bao, Bianxiao Cui, Sergiu P Pasca
Released: 13-Jun-2022 12:00 PM EDT
Comparison of antibacterial effect of Plantaricin 149 suspension and traditional root canal irrigation solutions in root canal infections in vitro
PreprintsYing Wang, Keda Chen, Xiaolong Lin
Released: 13-Jun-2022 12:00 PM EDT
Nervous system reduction in branched-chain amino acid metabolism disrupts hippocampal neurogenesis and memory
PreprintsKhadar Abdi, Ramona Rodriguez, William C Wetsel, Michelle E Arlotto, Robert W McGarrah, Phillip J White
Released: 13-Jun-2022 12:00 PM EDT
Phospholipase D1 promotes astrocytic differentiation through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural stem/progenitor cells
PreprintsMin-Jeong Kang, Nuri Jin, Shin-Young Park, Joong-Soo Han
Released: 13-Jun-2022 12:00 PM EDT
Generation of Cerebral Organoids with Enriched Cortical Cellular Diversity and Outer Radial Glial Cell Identity from Human Pluripotent Stem Cells
PreprintsYechiel Elkabetz, Sneha Arora, Anastasios Balaskas, Amèlia Aragonés Hernández, Daniel Rosebrock
Released: 13-Jun-2022 12:00 PM EDT
ΔNp63α Transcriptionally Represses p53 Target Genes Involved in the Radiation-Induced DNA Damage Response
PreprintsKen-Ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Sakai
Released: 12-Jun-2022 12:00 PM EDT
A Development-Inspired Niche for Homeostatic Human Mini-Intestines
PreprintsCharlie J Childs, Emily M Holloway, Caden W Sweet, Yu-Hwai Tsai, Angeline Wu, Joshua Wu, Oscar Pellon Cardenas, Meghan M Capeling, Madeline Eiken, Rachel Zwick, Brisa Palikuqi, Coralie Trentesaux, Charles Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, Gray Camp, Jonathan Z Sexton, Ophir D Klein, Michael P Verzi, Jason J Spence
Released: 12-Jun-2022 12:00 PM EDT
Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture
PreprintsEster Gil Vasquez, Nadia Nasreddin, Gabriel N Valbuena, Eoghan J Mulholland, Hayley L Belnoue-Davis, Holly Eggington, Ryan O Schenck, Valerie M Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R M Lannagan, Dustin J Flanagan, Arafath K Najumudeen, Sulochana Omwenga, Amy M B McCorry, Alistair Easton, Viktor H Koelzer, James E East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D Campbell, Maurice B Loughrey, Philip D Dunne, Petros Tsantoulis, David J Huels, Sabine Tejpar, Owen Sansom, Simon J Leedham
Released: 12-Jun-2022 12:00 PM EDT
Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey
PreprintsRavi Jagasia, Charlotte Bon, Soren V. Rasmussen, Solveig Badillo, Disa Tehler, Daniele Buchy, Marco Berrera, Megana Prasad, Marco Terrigno, Nikhil J. Pandya, Veronica Costa, Congwei Wang, Lykke Pedersen, Meghan T Miller, Kamille Dumong Erichsen, Lars Joenson, Joerg Hipp, Azad Bonni, Lutz Mueller, Annamaria Braendli-Baiocco, Thomas Kremer, Erich Koller, Marius Hoener
Released: 12-Jun-2022 12:00 PM EDT
Antiviral Therapy Defiant Polyviral Retinitis Post Hematopoietic Allogeneic Stem Cell Transplant
PreprintsNadia Gabarin, Mili Roy, Alexander J. Kaplan, Shariq Haider, Dina Khalaf
Released: 11-Jun-2022 12:00 PM EDT
A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target
PreprintsAna Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J Hope
7-Jun-2022 9:00 AM EDT
Stem-Cell Based Therapy Shows Promise in Treating High-Risk Type 1 Diabetes
Endocrine SocietyAn investigative stem cell-based therapy called PEC-Direct, designed to act as a replacement pancreas, has the potential to provide blood sugar control in patients with high-risk type 1 diabetes, suggests a clinical study presented Saturday, June 11 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
Released: 10-Jun-2022 11:30 AM EDT
Pediatric Urologist Dr. Anthony Atala to Receive 2022 Jacobson Innovation Award of the American College of Surgeons for Pioneering Work in Regenerative Medicine
American College of Surgeons (ACS)The Jacobson Innovation Award is an international surgical honor that recognizes living surgeons who are innovators of a new development or technique in any field of surgery. It is made possible through a gift from Julius H. Jacobson II, MD, FACS, and his wife Joan. Dr. Jacobson is a general vascular surgeon known for his pioneering work in the development of microsurgery. This year's recipient, Dr. Anthony Atala, is a pediatric urologist, researcher, professor, and mentor who is renowned for developing foundational principles for regenerative medicine research, which holds great promise for people who require tissue substitution and reconstruction.
Released: 9-Jun-2022 12:00 PM EDT
Hyaluronic acid biosynthesis promotes an invasive, stem-like cancer cell phenotype by broadly altering metabolism
PreprintsAdrian Adwait Shimpi, Matthew Lee Tan, Michael Vilkhovoy, David Dai, Ladeidra Monet Roberts, Joe Chin-Hun Kuo, Lingting Huang, Jeffrey Varner, Matthew J Paszek, Claudia Fischbach
Released: 9-Jun-2022 12:00 PM EDT
The Korean Undiagnosed Diseases Program Phase I: Expansion of the Nationwide Network and the Development of Long-term Infrastructures
PreprintsSoo Yeon Kim, Seungbok Lee, Hyewon Woo, Young Jun Ko, Youngkyu Shim, Soojin Park, Se Song Jang, Byung Chan Lim, Jung Min Ko, Ki Joong Kim, Anna Cho, Hunmin Kim, Hee Hwang, Ji Eun Choi, Man Jin Kim, Jangsup Moon, Moon-Woo Seong, Sung Sup Park, Sun Ah Choi, Ji Eun Lee, Young Se Kwon, Young Bae Sohn, Jon Soo Kim, Won Seop Kim, Yun Jeong Lee, Soonhak Kwon, Young Ok Kim, Hoon Kook, Yong Gon Cho, Chong Kun Cheon, Ki-Soo Kang, Mi-Ryoung Song, Hyuk-Jin Cha, Hee-Jung Choi, Yun Kee, Seung Tae Baek, Murim Choi, Jong-Hee Chae, Dong-Sung Ryu
Released: 9-Jun-2022 12:00 PM EDT
Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimer's Disease
PreprintsYubing Liu, Bensun Cambell Fong, Richard A Harris, Marie-Michelle McNicoll, Amaal A Abdi, Jacob B Cuthbert, David P Cook, Daniel Figeys, Jing Wang, Barbara C Vanderhyden, Ruth S Slack
Released: 9-Jun-2022 12:00 PM EDT
Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles
PreprintsYuta Baba, Saki Onishi-Sakamoto, Kaori Ide, Koji Nishifuji
Released: 9-Jun-2022 12:00 PM EDT
A Retrospective Study of Treatment and Outcomes of Patients with Lymphoma Undergoing Hematopoietic Stem Cell Transplantation
PreprintsMerve Gozde Sezgin, Hicran Bektas
Released: 9-Jun-2022 11:35 AM EDT
First-of-its-Kind Stem Cell and Gene Therapy Highlighted at Annual Stem Cell Meeting
Cedars-SinaiInvestigators from Cedars-Sinai will present the latest novel stem cell and regenerative medicine research at the International Society for Stem Cell Research (ISSCR) Annual Meeting, which is being held in person and virtually June 15-19 in San Francisco.
Released: 8-Jun-2022 2:05 AM EDT
Double Agents: How Stomach Stem Cells Change Allegiance Upon Injury
Institute of Molecular BiotechnologyThe interest of scientists in adult stem cells resides in their ability to self-renew indefinitely and differentiate into all cell types making up the organ where they reside.
Released: 7-Jun-2022 5:05 PM EDT
Stem Cells Either Overproduce or Underproduce Brain Cells in Autism Patients
Rutgers University-New BrunswickAnalyzing brain stem cells of patients with autism spectrum disorder (ASD), Rutgers scientists have found evidence of irregularities in very early brain development that may contribute to the neuropsychiatric disorder.
Released: 7-Jun-2022 12:00 PM EDT
Metadichol, A natural ligand for expression of Yamanaka reprogramming factors in somatic and primary cancer cell lines
PreprintsP.R. Raghavan
Released: 7-Jun-2022 12:00 PM EDT
Effect of Electrical Stimulation on Spinal Cord Injury: In Vitro and In Vivo Analysis
PreprintsWoo-Seok Bang, Inbo Han, Seul-Ah Mun, Dae-Chul Cho, Sang-Woo Lee, Byoung-Joon Kim, Chi Heon Kim, Hyuk Choi, Kyoung-Tae Kim
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