Feature Channels: Stem Cells

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Guomin Li, Xu Han, Ye Wu, Wei Wang, Hong-Xia Tang, Mei-Ping Lu, Xue-Mei Tang, Yi Lin, Fan Deng, Jun Yang, Xin-Ning Wang, Cong-Cong Liu, Wen-Jie Zheng, Bing-Bing Wu, Fang Zhou

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Brijesh Kumar, Katie Batic, Poornima Bhat-Nakshatri, Maggie M Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J Temm, George Sandusky, Sandra K Althouse, Anna Maria Storniolo, Harikrishna Nakshatri

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Ao Fang, Yifan Wang, Naiyu Guan, Lingmin Lin, Binjie Guo, Wanxiong Cai, Xiangfeng Chen, Jingjia Ye, Zeinab Abdelrahman, Shuang Jin, Bin Yu, Xiaosong Gu, Xuhua Wang

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Andrew D Duckworth, Cath Eberlein, Victoria Pollard, Richard Bethell, Joseph R Slupsky, Oliver Schon, John F Woolley, Tiffany Thorn

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Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell,

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Peng Ding, Chuan Gao, Youshui Gao, Delin Liu, Hao Li, Jun Xu, Xiaoyi Chen, Yigang Huang, Changqing Zhang, Ming Hao Zheng, Junjie Gao

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Wenxuan Wang, Chun Fan, Xinbo Yu, Xu Qiu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Qiuxia Ji

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Tarik Hadid, Ayad Al-Katib, Jose Binongo, Gina M. Berteotti, Salman Fazal, James M. Rossetti, John Lister

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Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Martin J Lohse, Paolo Annibale

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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Abstract: Background: Clinical and research based genetic testing has uncovered genes that encode chromatin modifying complex components required for organogenesis. Covalent histone modifications play a key role in establishing transcriptional plasticity during development, required for cell fate specification, and have been implicated as a developmental mechanism that accounts for autism spectrum disorder (ASD) and CHD co-occurrence. ASXL3 has been identified as a high confidence ASD gene. ASXL3 is a component of the Polycomb Repressive Deubiquitination (PR-DUB) complex, which deubiquitinates histone H2A. However, the role of ASXL3 in cardiac development remains unknown.

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Neuroinflammation and activated microglia play important role in neuron damage in the traumatic brain injury (TBI). In this study, we determined the effect of human umbilical cord mesenchymal stem cells (UMSCs) combined with monosialotetrahexosy 1 ganglioside (GM1) on the neuroinflammation and polarization of microglia in a rat model of TBI, which was established in male rats using a fluid percussion brain injury device.

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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KPTN-related disorder (KRD) is an autosomal recessive disorder associated with germline variants in KPTN (kaptin), a component of the mTOR regulatory complex KICSTOR.

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Alternative splicing of neuronal genes is controlled in part by the coordinated action of the polypyrimidine tract binding proteins (PTBP1 and PTBP2).

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Vascular cambium contains bifacial stem cells, which produce secondary xylem to one side and secondary phloem to the other.

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Olfactory mucosa is well-known for its lifelong ability for regeneration. Regeneration of neurons and regrowth of severed axons are the most common neural repair mechanisms in olfactory mucosa.

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The polygenic and multifactorial nature of many psychiatric disorders has hampered the personalized medicine approach implementation in clinical practice.