Feature Channels: Stem Cells

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Woranop Sukparangsi, Ampika Thongphakdee, Santhita Karoon, Nattakorn Suban Na Ayuttaya, Intira Hengkhunthod, Rachapon Parkongkeaw, Rungnapa Bootsri, Wiewaree Sikaeo

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Human nuclear receptors (NRs) involve 49 ligand-dependent transcription factors that are important for regulating the cell cycle and processes.

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Clonal hematopoiesis resulting from enhanced fitness of mutant hematopoietic stem cells (HSCs) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear.

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Metazoan chromosomes are organized into discrete domains (TADs), believed to contribute to the regulation of transcriptional programs.

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Mesenchymal stem cell (MSC) transplantation was suggested as a promising approach to treat spinal cord injury (SCI).

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The molecular mechanisms controlling the balance of quiescence and proliferation in adult neural stem cells (NSCs) are often deregulated in brain cancers such as glioblastoma (GBM).

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Xiaotong Chen, Yanqiu Zhao, Qi Li, ShengJin Fan

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Intramuscular fatty infiltration in muscle injuries and diseases, caused by aberrant adipogenesis of fibro-adipogenic progenitors, negatively impacts function.

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Tyrosine kinase inhibitors (TKI) have revolutionised the treatment of CML.

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A common feature in the gastrointestinal (GI) tract during allogeneic hematopoietic stem cell transplantation is the loss of microbial diversity and emergence of opportunistic pathogens that can adversely impact survival.

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The repair of critical-sized bone defects, resulting from tumor resection, skeletal trauma or infection, remains a significant clinical problem.

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The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes.

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Dietary quantity and quality are key determinants for insect development from egg to adult.

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The importance of the immune microenvironment in ovarian cancer progression, metastasis, and response to therapies has become increasingly clear, especially with the new emphasis on immunotherapies.

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Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been demonstrated to be effective in the treatment of OA, but the precise target cells and response mechanisms are not well characterised.

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Bi-allelic loss-of-function mutations in TANGO2 (Transport and Golgi Organization protein 2) cause a rare multiorgan genetic disorder.

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Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma stem cell (GSC) self-renewal, invasiveness and tumorigenicity.

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Autism spectrum disorder (ASD) is a heterogenous, early-onset neurodevelopmental disorder with multifactorial aetiology. There are hundreds of genes that contribute to ASD.

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Environmental obesogens are being studied for their potential role in the increasing prevalence of obesity globally.