Four proposed state-of-the art image search engines for automating search and retrieval of digital histopathology slides were found to be of inadequate performance for routine clinical care. Some had less than 50% accuracy, which is not suitable for clinical practice.
Researchers say a machine learning tool can identify many patients with rare, undiagnosed diseases years earlier, potentially improving outcomes and reducing cost and morbidity. The findings, led by researchers at UCLA Health, are described in Science Translational Medicine.
A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.
Challenges remain in ensuring equitable access to screening and addressing gaps in evidence regarding supplemental screening modalities and the adoption of artificial intelligence (AI) technologies, notes Joann Elmore, MD, MPH, a professor of medicine at the David Geffen School of Medicine at UCLA in a newly published editorial in JAMA.
UCLA Health is part of a multi-institution research team to receive a contract for up to $33 million from the federal Advanced Research Projects Agency for Health (ARPA-H) for the development of new treatments specifically focused on joint regeneration for osteoarthritis.
For undocumented Latinx patients who sought care in the emergency room during the pandemic, the reported rate of having received the COVID-19 vaccine was found to be the same as U.S. citizens, a new UCLA Health study found.
Faculty, scientists, and urologists from UCLA Health Urology will present research data on the latest discoveries and innovations in urology at the 2024 American Urological Association’s (AUA) Annual Meeting in San Antonio, Texas, May 3-6.
A new UCLA Health study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson’s disease.
The FDA approval was based on results of the QUILT 3.032 clinical trial, which was led by Dr. Karim Chamie, associate professor urology at the David Geffen School of Medicine at UCLA and a researcher at the UCLA Health Jonsson Comprehensive Cancer Center.
Patients have lower rates of mortality and hospital readmissions when treated by female physicians, with female patients benefitting more than their male counterparts.
UCLA Health researchers will be co-principal investigators in the Untangling Addiction program launched this year by the nonprofit health research organization Wellcome Leap. The three-year, $50 million project includes 13 other partnering universities and organizations and is aimed at developing new ways to quantify addiction risk and progression through biomarkers.
A new analysis by researchers at UCLA Health found that mortality rates of middle-aged Black Americans caused by the “deaths of despair” -- suicide, drug overdose and alcoholic liver disease – surpassed the rate of white Americans in 2022.
A mutation in a protein regulating natural killer (NK) cells’ function is at the root of immune deficiency in some people with a rare genetic condition characterized by cognitive and developmental delay, seizures, and other manifestations. The findings also have broader implications for immunity and cell therapies.
A pilot study led by UCLA Health Jonsson Comprehensive Cancer Center investigators suggests that for people with borderline resectable pancreatic cancer, administrating an immunotherapy drug in combination with chemotherapy before surgery is safe and may improve long-term outcomes.
Study finds that lonely women experienced increased activation in regions of the brain associated with food cravings.
Women with serious mental illness (SMI) who are pregnant or planning a pregnancy face gaps in information, support and resources in mental health services. The findings highlight the need to integrate pregnancy and parenting interventions, education, and other resources for women with SMI.
Dr. Rhonda Voskuhl, a professor of neurology at UCLA Health, has been awarded the 2024 John Dystel Prize for Multiple Sclerosis Research in recognition of her outstanding contributions to multiple sclerosis research and treatment.
HERSTORY is focused on understanding genetic, environmental, socio-economic, and other determinants of cancer in women with a family history of the disease.
The results of a UCLA study suggest that using CXCL9 and CXCL10-producing dendritic cells alongside immunotherapy can be a promising strategy to overcome treatment resistance and improve clinical outcomes for patients with non-small cell lung cancer.
The annual meeting will feature more than 40 regular, late-breaking and clinical trial abstracts from UCLA physicians and scientists, who will present their latest work in key areas of translational and basic scientific research, including new compounds and drug targets, combination immunotherapy approaches, updated organoid models, survivorship research and more.
A vaccine against the bacterium that causes melioidosis was highly protective against the disease, which is endemic in many tropical areas, causing approximately 165,000 cases with 89,000 fatalities around the world each year. It is so dangerous that it is categorized as a Tier 1 Select Agent of bioterrorism.
A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators.
Text nudges encouraging people to get the COVID-19 vaccine, which had proven effective in prior real-world field tests, are also effective at prompting people to get a booster. The key in both cases is to include in the text a sense of ownership in the dose awaiting them.
A team of UCLA Health Jonsson Comprehensive Cancer Center investigators has shown the combination of a short course of powerful and intense hormonal therapy with targeted radiation is safe and effective in treating people with prostate cancer that has come back and has spread to other parts of the body.
The UCLA Department of Medicine is pleased to announce that Priscilla Hsue, MD will be joining us as the chief of the Division of Cardiology at UCLA, effective July 1, 2024.
A new UCLA-led study suggests that some people living with long COVID may be able to alleviate certain symptoms by using short-term, self-regulating therapies.
A team of investigators from the UCLA Health Jonsson Comprehensive Cancer and the University of Arkansas for Medical Sciences (UAMS) Winthrop P. Rockefeller Cancer Institute was awarded a $3.2 million grant from the National Institutes of Health to identify new ways to prevent and overcome treatment resistance to targeted therapy in patients with all sub-types of cutaneous melanoma, an aggressive form of skin cancer.
A new training protocol to assist first responders in recognizing and responding to symptoms of heart events in women is being rolled out.
UCLA Health researchers have discovered a group of specialized support cells in the brain that can regulate behaviors associated with human neuropsychiatric disorders.
Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.
A new UCLA Health study found Kundalini yoga provided several benefits to cognition and memory for older women at risk of developing Alzheimer’s disease including restoring neural pathways, preventing brain matter decline and reversing aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.
For Colon Cancer Awareness Month, experts from the UCLA Health will educate members of the community on the importance of starting colorectal cancer screening early and continuing to have it done regularly throughout their lives to prevent the development of cancer.
Samara Rahman, 74, enrolled in a clinical trial at UCLA Health that was evaluating an “off-the-shelf” vaccine that is given after surgery to prevent or delay the cancer from coming back in high-risk patients.
Folasade May, MD, PhD, UCLA Health cancer prevention researcher and gastroenterologist, is available for interview on a variety of topics during colorectal cancer awareness month.
A UCLA Health-led study found a combination of interventions of one-on-one telehealth coaching, peer support forums, and automated text messages more than doubled the use of the HIV prevention strategy, called PrEP, among younger, at-risk Americans, a group that historically has had low use of the medication.
Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.
A four-drug chemotherapy regimen of irinotecan liposome (Onivyde) in combination with oxaliplatin, leucovorin, and fluorouracil has been approved by the FDA for the first-line treatment of metastatic pancreatic adenocarcinoma.
UCLA Therapy dogs dressed in costumes deliver Valentines to pediatric patients on the unit.
A new study, co-led by UCLA Health and the University of Glasgow, found that young teenagers who develop a strong distrust of other people as a result of childhood bullying are substantially more likely to have significant mental health problems as they enter adulthood compared to those who do not develop interpersonal trust issues.
Therapy dogs dressed in costumes deliver Valentines to pediatric patients on the unit.
The UCLA team played a pivotal role in a clinical trial that led to the FDA granting accelerated approval of the first antibody drug conjugate (ADC), mirvetuximab soravtansine, for the treatment of platinum-resistant ovarian cancer.
Genicular artery embolization is a non-invasive alternative to knee replacement.
New prostate screening guidelines organized by the Prostate Cancer Foundation aim to address the longstanding health disparity in prostate cancer: Black men are diagnosed with and die from prostate cancer at a much higher rate than white men.
A UCLA Health-led evaluation of Los Angeles County’s pilot program aimed at bolstering aid to gravely disabled homeless residents found the initiative could offer a promising framework to improve housing and health outcomes for this vulnerable population while also relieving overburdened psychiatric hospitals.
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