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The American Association for Cancer Research announces the launch of its newest journal, Cancer Discovery, which will publish high-impact, peer-reviewed articles describing major advances in basic and clinical research. Its unique format will feature game-changing research, review articles, perspectives and commentaries, news, and “Research Watch” summaries of important journal articles. Cancer Discovery is a new addition to the AACR’s robust publication program.

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1) Test found 64 percent of colorectal pre-cancers and 85 percent of cancers; 2) Validation study included 1,100 patient samples; 3) Ease of use could increase screening rates.

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1) Y15, a novel FAK inhibitor, may be useful for treating colon cancer; 2) Y15 targets a specific site on the Y397 molecule.

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1) Researchers will present validation study of more than 1,100 patients; 2) Test can be done conveniently with a stool sample; 3) Early testing showed high specificity and sensitivity.

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1) Colon cancer stem cells may be the root of therapy resistance; 2) Idea is to shut down cells that continually revive tumors; 3) First model that shows how a single colon cancer stem cell behaves.

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1) More specific target increases efficacy, decreases toxicity; 2) Small-molecule inhibitors could be developed into oral-based therapies.

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1) MicroRNA variant also predicts worse survival in later stages of cancer; 2) Variant leads to ineffective regulation of KRAS; 3) Another pathway may be regulating tumor growth.

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1) Telomeres of some young-onset colorectal cancer patients showed accelerated aging; 2) Other patients had telomeres longer than those of young healthy people.

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John D. Groopman, Ph.D., has been selected to receive the 2010 American Association for Cancer Research-Prevent Cancer Foundation Award for Excellence in Cancer Prevention Research.

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The American Association for Cancer Research expresses its congratulations to and appreciation of William S. Dalton, M.D., Ph.D., who will receive the 2010 Leadership in Personalized Medicine Award from the Personalized Medicine Coalition (PMC).

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1) Press conference held on Thursday, Oct. 28 at 1:00 p.m. ET at the Loews Hotel; 2) New DNA methylation test may change screening landscape; 3) Emerging targeted treatments show promise in hard to treat cases.

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The American Association for Cancer Research calls upon the cancer research community to submit Letters of Intent for Stand Up To Cancer’s Innovative Research Grants (IRG), which support the next generation of extraordinary cancer research leaders in their quest to conquer cancer.

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An article published in the fall 2010 issue of CR, the AACR’s magazine for cancer survivors and their families and caregivers, details the immense challenges faced by those who suffer with cancer and lack the necessary resources for proper treatment and care — the homeless.

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The American Association for Cancer Research congratulates 12 of its members on their election into the Institute of Medicine. They are among the 65 new members and five foreign associates.

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The 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium will honor two leading breast cancer researchers during its meeting, which will be held Dec. 8-12 in the Henry B. Gonzales Convention Center, San Antonio, Texas. Klaus Pantel, M.D., Ph.D., is the recipient of the 2010 AACR Outstanding Investigator Award for Breast Cancer Research, funded by Susan G. Komen for the Cure®. Alan Ashworth, Ph.D., will give the 2010 AACR Distinguished Lectureship in Breast Cancer Research.

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PHILADELPHIA — Researchers at Kaiser Permanente have found that patients with a very early form of breast cancer (ductal carcinoma in situ or DCIS) who have higher mammographic density may be at increased risk for subsequent breast cancer, especially in the breast opposite to the one with the initial cancer.

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This November, the American Association for Cancer Research will host its Ninth Annual International Conference on Frontiers in Cancer Prevention Research at the Pennsylvania Convention Center, located in Philadelphia. Thousands of scientists will gather to discuss new data on lifestyle modifications, chemoprevention and other strategies.

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This October, the American Association for Cancer Research will host the special conference Colorectal Cancer: Biology to Therapy at the Loews Philadelphia Hotel. Hundreds of scientists, physicians and allied health professionals will gather and discuss new data on new screening methods and emerging therapies.

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1) Time to diagnosis twice as long for insured minorities vs. insured white women; 2) Diagnostic delay twice as long for uninsured vs. insured black women.

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1) Despite insurance and incomes, racial disparities in treatment delay exist; 2) Disparities have not improved; may have worsened over time.

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1) Biological tumor differences seen in Hispanics and Asians; 2) Surgery led to higher survival rates; underwent by fewer black patients; 3) Bronchoalveolar lung cancer had a better prognosis.

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1) Women with this cancer subtype have more than twice the risk of death; 2) Poor prognosis linked to age at diagnosis and regional/distant disease.

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1) Study conducted among patients with uterine cancer; 2) African-Americans had higher death rates, even with insurance; 3) Mortality higher among patients with public vs. private insurance.

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1) Fewer nonwhite female cancer survivors spoke with a friend or family member about their health; 2) Social support often key to continued health.

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As part of the Third AACR Conference on The Science of Cancer Health Disparities, Olveen Carrasquillo, M.D., M.P.H., chief of the division of general medicine at the University of Miami, Miller School of Medicine in Florida, will host a press conference on Friday, Oct. 1, at 6:00 p.m. in the Cowrie 2 Room of the Loews Hotel in Miami.

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1) Fifty-six percent of Puerto Ricans have heard about direct-to-consumer genetic testing; 2) Only 4.3 percent of Puerto Ricans have used a genetic test; 3) Awareness of genetic testing in Puerto Rico is higher, but use is lower, compared with the United States.

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1) Lower levels may be linked to aggressive breast cancer; 2) Findings suggest possible prevention strategy; 3) Vitamin D levels should be monitored closely.

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1) A multidimensional holistic approach reduced fatigue in blacks and whites; 2) Persistent fatigue may last for years after breast cancer treatment.

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1) Study conducted among Puerto Ricans; 2) DNA repair capacity assessment may predict skin cancer risk even at an early age; 3) Non-melanoma skin cancer risk could be lowered by increasing DNA repair capacity.

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1) Large study shows cancer patients have significant memory problems; 2) Impairment may be linked to biology, treatments and biological predisposition; 3) Strategies to diagnose and treat memory impairments are needed.

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1) Increase seen in both premenopausal and postmenopausal women; 2) Women who smoked between puberty and first childbirth had an increased risk.

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1) As little as two hours a week of vigorous exercise reduces risk; 2) Benefits are seen with regular walking as well.

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1) Association between low socioeconomic status and colorectal cancer is independent of other risk factors; 2) Public health programs and practitioners should target these areas.

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1) Assay allows classification into four distinct subtypes; 2) Subtype analysis may enable more effective therapeutic assignment; 3) Test works on preoperative fine needle aspirates and biopsies.

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1) Earlier PSA detection could affirm that cancer is “cured” or needs earlier treatment; 2) Test is 1,000 to 10,000 times more sensitive than leading PSA tests; 3) Able to measure PSA in all blood samples previously categorized as “below detection levels.”

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1) Robust profiling of miRNAs from plasma is feasible using LNA™-enhanced technology; 2) miRNA profiles in plasma can detect early-stage colorectal cancer; 3) Plasma miRNA is a promising new biomarker for diseases, including cancer.

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1) The On-Q-ity C5 chip enables more accurate clinical decision making; 2) Chip provides better, more accurate prognosis, diagnosis and treatment prediction.

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1) Nanoscale proteomic method identifies potential biomarkers; 2) Specific isoforms of signaling proteins associated with clinical response to agents that target cancer pathways; 3) Nanoscale profiling can help distinguish malignant and non-malignant cells.

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1) c-Met activation linked with poor prognosis; 2) c-Met was highly overexpressed in metastatic liver cancer cells.

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1) Scientists are using a microRNA panel to determine presence of disease; 2) Bladder cancer is the fourth leading cause of cancer in men; 3) Most bladder cancer is detected in later stages.

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• Large study shows equal prevalence of EGFR mutations. • EGFR mutations among African-Americans more likely to be found on exon 19, rather than exon 21. • Patients with EGFR mutations are more likely to respond to erlotinib.

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The American Association for Cancer Research will host its Third Conference on The Science of Cancer Health Disparities at the Loews Hotel in Miami from Sept. 30 to Oct. 3, 2010.

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1) Panels of up to15 biomarkers identify patients with cancer with high accuracy; 2) Performance is considerably better than current clinical tests; 3) Test could flag cancer years before symptoms begin.

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1) Some patients with triple-negative breast cancer overexpressed IGF-1R; 2) Expression of IGF-1R is associated with longer survival; 3) Data provides potential target for new drugs.

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1) Novel biomarkers will enable early detection of aggressive cancers; 2) Results verify initial discoveries; validation studies underway; 3) Discoveries result from breakthrough aptamer-based proteomic array technology.

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1) Similar CTC capture efficiency observed in CellSearch and biochip platforms; 2) Biomarker status in CTCs is reflective of status in tumor tissue; 3) Evidence of using CTCs as “tissue source” in predictive diagnostics.

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1) Tivozanib being tested in multiple tumor types; 2) Research includes Phase III trial in kidney cancer.

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The American Association for Cancer Research is currently accepting nominations for the following awards, which will be presented at the AACR 102nd Annual Meeting 2011 in Orlando, Fla., from April 2 to 6. The nomination deadline for the awards below is Oct. 15, 2010.

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1) Conference to focus on the latest in personalized medicine; 2) New clinical data on diagnostic methods and therapeutics presented; 3) Press conference to be held on Sept. 28 at 1:00 p.m. MT.

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Stand Up To Cancer today announced that in connection with the September 10, 2010, simultaneous commercial-free telecast, more than $80 million has been pledged so far to accelerate ground-breaking research and bring new treatments to patients as quickly as possible. The telecast is available online at www.su2c.org/2010show. Donations can continue to be made online at www.su2c.org and at 1-888-90-STAND (78263).