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The deadline for nominations is Sept. 6, 2012.

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• Disease has high heterogeneity. • First-line chemosensitivity associated with subsequent chemoresistance. • Gene identified that may predict chemoresistance.

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• Denosumab reduced bone-related complications and need for radiation therapy. Treatment improved health-related quality of life. • May replace standard bisphosphonate treatments like zoledronic acid.

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• In a mouse xenograft model, TRPM7 drives breast cancer cell metastasis. • Class of proteins exemplified by TRPM7 should be explored as a potential therapeutic target.

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Research efforts will investigate DNA-guided personalized cancer treatment approaches.

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New senior editorial team announced.

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• Immune cell activation seen in skin metastases from melanoma patients. • Structures supported active B lymphocyte responses.

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• Lack of IDO protein reduced tumor burden in primary and metastatic lung cancer models. • In both models, loss of IDO improved survival. • Mechanisms by which IDO promoted tumorigenesis were identified.

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Grant nominations are now open: deadline is Tuesday, August 21, 2012.

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Law will allow the FDA to use innovative approaches to provide lifesaving treatments and cures.

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• Risk of basal cell carcinoma and coffee intake inversely associated. • No association with risk of other forms of skin cancer, including melanoma. • Caffeine most likely component of coffee responsible for the effect.

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• BAY 86-9766 offers survival benefit in mouse model of pancreatic cancer. • Treatment yields remarkable tumor regression rapidly. • Therapy effective in mice with advanced tumors.

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• A high-fat/calorie diet speeds development of precancerous lesions in mice. • Diet produces obese mice with pancreatic inflammation. • Human obesity may promote pancreatic cancer development.

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• Forty weak biomarkers must be identified. • Disease heterogeneity makes single biomarker diagnostics problematic.

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• Combining erlotinib with bevacizumab, capecitabine and radiation is well tolerated by pancreatic cancer patients. • Treatment enabled some patients with previously unresectable tumors to have their tumors surgically removed. • The encouraging median survival indicates the combination has promise as a potential new treatment option.

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• Cancer stem cells sensitive to metabolic reprogramming with metformin. • Metformin effectively combined with standard pancreatic treatments. • Approach ready for clinical trials.

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• Variant of vitamin D receptor gene associated with higher overall survival. • The variant increases levels of vitamin D receptor expression in in vitro assays. • Study refocuses attention on role of the vitamin D pathway in affecting the disease course.

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• KRAS protein is a key driver of most cases of pancreatic cancer. • KRAS, working via leukemia inhibitory factor, promotes the generation and maintenance of pancreatic cancer stem cells. • LIF shows promise as a target for pancreatic cancer treatment.

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• High levels of hypoxia in xenografted pancreatic tumors predict aggressive growth and enhanced metastatic potential. • Treatment efficacy of the hypoxia-targeting prodrug TH-302 depended on level of hypoxia and tumor growth rate. • Results provide additional rationale for ongoing clinical trials with TH-302.

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• Levels of a fusion product of the SLC45A3 and ELK4 genes correlated with prostate cancer disease progression. • The fusion product controlled proliferation of prostate cancer cell lines. • An unusual pathway and not chromosomal rearrangement led to fusion product expression.

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• Severe pain is a common symptom of pancreatic cancer. • Levels of four neurotrophic factors were elevated in a pancreatic cancer model. • Nerve bundles in the pancreas were larger and physical activity lower.

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• Study supports link between high sun exposure and lower pancreatic cancer risk. • History of skin cancer and sun-sensitive skin type decreased pancreatic cancer risk.

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• New approach has potential to change the way pancreatic cancer is treated. • GDC-0449 targets the Hedgehog signaling pathway. • Inhibiting this pathway may improve the efficacy of chemotherapy.

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• RLIP76 expression is elevated in pancreatic cancer cells. • Blocking RLIP76 shrinks human pancreatic tumors implanted in mice. • RLIP76 plays a key role in pancreatic cancer cell resistance to chemotherapy and radiation.

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AACR President Frank McCormick, Ph.D., F.R.S., D.Sc. (hon.), will serve on a top-tier panel of expert witnesses tomorrow, June 19, when the Senate Cancer Coalition convenes a congressional forum, “Preventing and Treating Breast Cancer in the 21st Century: Seeking the Right Treatment at the Right Time.”

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• JAK3 mutations detected in 35 percent of NK/T-cell lymphoma patients tested. • Mutations increased growth of cultured NK/T-cell lymphoma cell lines. • JAK inhibitor increased cell death, suggesting a new therapeutic approach.

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Leaders in cancer community to focus on how we define value, address need for health care cost containment, and sustain innovation to turn the tide against cancer

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The Personalized Medicine Coalition, American Association for Cancer Research, and Feinstein Kean Healthcare are convening the Turning the Tide Against Cancer Through Sustained Medical Innovation national conference to consider the status and future of cancer innovation and personalized medicine. While recent scientific advances have generated both excitement and challenges in preventing, detecting, diagnosing, and treating cancer, there is an increasing recognition that our national policies are far from optimal in this new era of rapidly advancing personalized oncology.

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• Final phase III trial analyses substantiate interim results that led to FDA approval. • Crossover trial design worked and benefitted patients. • Long-term overall survival benefit estimated with no new adverse events.

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Tobacco use is the leading preventable cause of premature death in the United States. It causes no fewer than 18 different types of cancer and is responsible for nearly a third of all cancer deaths. Every conceivable method should be employed to combat this preventable epidemic, and that is why the American Association for Cancer Research strongly supports Proposition 29, The California Cancer Research Act.

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The American Association for Cancer Research is pleased to announce that it has received three coveted 2012 Hermes Creative Awards for its two most recent Annual Meeting videos and one video highlighting the AACR Cancer Progress Report 2011.

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• Study indicates relationship between weight loss and cancer risk. • Patients had a manageable goal of 10 percent weight loss. • Participants were overweight or obese, postmenopausal women.

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• Patients with lung cancer and KRAS mutation responded well to antifolate therapy. • Response linked to downregulation of KRAS expression. • Downregulation may render cells more susceptible to chemotherapeutic drug.

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• Patients with nonprogressive disease had improved survival rates. • Five-year survival rate for stage 3B/4 patients was 50 percent.

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• High hormone levels linked to longer survival regardless of treatment. • Biomarker provided meaningful method for patient stratification. • Data should inform future clinical trial design.

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• Risk for prostate cancer recurrence increased as excess body weight increased. • Obese and overweight men were at higher risk. • Body weight status and related lifestyle factors could be used to predict risk.

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• Caffeine and exercise decreased risk for sunlight-caused skin cancers in mice. • Results suggest that fat and tumor growth are related. • Findings link caffeine and exercise with lower levels of inflammation.

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• Intake associated with decreased mortality and recurrence rates. • Dose–response relationship observed. • Researchers recommend survivors eat more cruciferous vegetables.

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• Fifty-one percent of people who have had cancer died from cancer. • Forty-nine percent of cancer survivors died from other conditions. • Researchers encourage a more comprehensive approach to survivor health.

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• Disease prevalence similar between Hispanics in Puerto Rico and California. • Researchers suggest that biology of disease drives tumor behavior. • Expression of estrogen receptor associated with better prognosis.

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• Patients did not have to adjust lifestyle or common drugs for this test. • Age affected four methylation markers studied, but to different extents. • Selecting optimal methylation markers may minimize false positives.

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• Nab-paclitaxel and carboplatin yielded a 41 percent response rate. • Toxicity of the combination is “tolerable.”

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• Drug’s epigenetic approach seeks to alter behavior of cancer cells. • Preliminary results show minimal toxicity. • Innovative approach to phase I trial seeks to establish optimal dosage.

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• Connaught strain of bacillus Calmette-Guérin proved superior. • Patients treated with Tice strain may be at increased risk for recurrence. • Genetic strain differences rather than dose and preparation at cause.

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• (S)-NNN is “only chemical in smokeless tobacco known to cause oral cancer.” • Carcinogen caused oral and esophageal tumors in every animal exposed. • Findings should influence regulatory decisions on smokeless tobacco.

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• Patients with breast cancer responded well to vaccine for recurrence prevention. • T regulatory cells decreased in patients assigned to the vaccine. • Immunologic testing may help identify responders to peptide vaccine.

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• Lower doses of IL-2 and 13-cis retinoic acid increased natural “killer” cells. • Combination therapy might benefit patients with stage 4 cancers. • Patients who received this combination had improved survival rates.

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• Eighteen of 22 children had regression, stable disease for more than three months. • Some children experienced immunological pseudoprogression.

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• Tumor burden reduction and disease stabilization occurred in some cases. • Tremelimumab also reduced blood levels of hepatitis C virus.

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• Stem cells had greater effect than differentiated tumor cells in eliciting antitumor immunity in vivo. • Antibodies and T cells targeted cancer stem cells in laboratory models. • Data could provide a rationale for a new type of immune therapy.