Researchers at the University of Maryland School of Medicine have made two breakthrough discoveries in interstitial cystitis, a chronic, painful bladder disorder for which there is no cure. Nearly half a million women suffer from IC. To be presented during Bladder Health Week, 10/24-31, published in November 1997 Journal of Urology.
University of Maryland School of Medicine researchers report that mature B cells have a molecular repair mechanism that can reactivate the process of genetic recombination to replace mutated and failing lymphocytes with ones producing the right antibodies. They can do it outside the bone marrow and in response to antigen.
University of Maryland researchers have confirmed the link between a calcium-handling enzyme and the strength of the heart's beat. They also have been able to enhance the heart's beating strength using a genetically altered adenovirus to give heart muscle cells extra copies of the gene that produces the crucial enzyme, ATPase.
At a World Congress of Neurology in Buenos Aires the week of September 14-19, neurologists from around the world will learn a new noninvasive technique for study and diagnosis of brain diseases. Neurology professors from the University of Maryland School of Medicine in Baltimore, Maryland, and from Rome, Italy will teach magnetic brain stimulation.
The first six hours after a motor skill is learned are a critical time when memory for the task is created in the brain. Once formed, the memory is moved to other parts of the brain for permanent storage and automatic recall, researchers report in the journal Science this week.
A toxic chemical that lurks in the environment for years causes a vaginal defect in unborn rats, reproductive biologists from the University of Maryland School of Medicine have found.
Researchers at the University of Maryland School of Pharmacy found poor folic acid dissolution in six prenatal prescription multivitamins they tested, raising questions as to whether or not absorption by the body is complete. Tests of nine prenatal prescription multivitamins found six products did not release at least 75 percent of the amount of folic acid listed on their labels in one hour, an industry standard set in 1995.
British colleagues warned Baltimore hypertension researcher Dr. Elijah Saunders that he would not be able to recruit enough African Caribbeans for a study of high blood pressure and dietary salt. He not only signed up the 150 he needed, he has 200 more waiting in line.
A study of first and second-generation African Caribbeans living in England found many undiagnosed cases of high blood pressure and more whose blood pressure medications were not adequately controlling their hypertension. It is the first study to focus on blood pressure, dietary salt and salt sensitivity among first and second-generation African Caribbeans living in the United Kingdom.
Castration has long been the primary strategy for the treatment of metastatic prostate cancer. However, researchers at the University of Maryland School of Medicine have identified new androgen inhibitors that they believe could supplant castration as the primary method of treatment.
This is the season for barbecues, picnics - and food poisoning. E. coli is a microbe normally found in the intestines of cattle. It gets into the food chain through undercooked meat and other contaminated food products. A symposium on the latest research, government food safety regulation and the response of the food and agricultural industry will be held in Baltimore June 22-26.
Shock can kill. A heart attack, stroke, infection or injury can cause the profound disturbance of normal cellular functioning that can lead to cell death and even death of the entire organism. University of Maryland School of Medicine researchers have found a potentially powerful new weapon for medicine's war on shock.
Significant racial differences in response to high blood pressure medications persist even when the variable of salt sensitivity is controlled.
When high blood pressure goes untreated, it enlarges the cells of the heart and produces a silent defect in the heart's pumping mechanism, a defect which turns out to be identical to one seen in heart failure. Embargoed: 05/02/97.
Endocrinologists have learned how estrogen helps maintain pregnancy and stimulates the process of fetal maturation. Estrogen helps prevent miscarriage by regulating the production of another hormone, progesterone, and jumpstarts the fetal maturation process by activating fetal production of cortisol, a steroid hormone vital for maturation of lungs and other organs. Embargoed until 3-22-97
The microbe that causes cholera has revealed the underlying mechanism for a promising new technology for oral delivery of drugs not normally absorbed through the intestines, such as insulin and immunoglobulins. Embargoed for release March 19, 1997
New technology has enabled physiologists at the University of Maryland School of Medicine to visualize the organization of intracellular calcium stored in the reticulum of cells. They also have located sodium pumps with a high affinity for the hormone ouabain next to the reticulum, where they play a vital role in controlling the storage and release of calcium. Findings could lead to new and better therapies for hypertension, heart failure, stroke.
Thyroid hormone may play a role in the hyperactive and impulsive symptoms of children with attention deficit-hyperactivity disorder (ADHD). Elevated levels of certain thyroid hormones correlate positively with hyperactivity and impulsivity, although not with inattention.
Neuroscientists at the University of Maryland at Baltimore have found that sugar and suckling activate natural pain-modulating systems in babies. They also learned that the pain of inflammation and injury is controlled at least in part in the spinal cord. EMBARGOED for release February 17, 1997, 5 p.m. EST
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