Altered shedding of epithelial cells from the intestinal lining is associated with multiple disorders, ranging from IBD to colorectal cancer. Researchers at CHLA looked at ways shedding and cell regeneration are controlled in healthy intestine, and found that shedding is negatively regulated by EGF.
The Children’s Center for Cancer and Blood Diseases (CCCBD) at Children’s Hospital Los Angeles is one of the first sites in the world to offer a promising new investigational therapy to treat pediatric acute lymphoblastic leukemia (ALL).
A new study led by researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) reports that the presence of leptin – a hormone secreted by fat cells that is critical to maintaining energy balance in the body -- inhibits the prenatal development of neuronal connections between the brain and pancreas. The findings could help explain the origin of type 2 diabetes, particularly in children of obese mothers.
Douglas Nordli, Jr., MD, has been named chief of the Division of Pediatric Neurology and co-director of the Neurosciences Center at Children’s Hospital Los Angeles (CHLA). Dr. Nordli will also serve as a vice chair of Neurology at the Keck School of Medicine of the University of Southern California.
Tracy C. Grikscheit, MD, of The Saban Research Institute of Children’s Hospital Los Angeles receives $7.1 million grant from the California Institute of Regenerative Medicine Translational Research program to develop a cellular therapy for the treatment of nerve disorders of the digestive system.
Children with a severe type of spina bifida have excess fat accumulation in their lower extremities. Researchers at Children’s Hospital Los Angeles determine that this excess fat tissue is within the muscle boundary may signify increased risk for metabolic disorders such as diabetes.
Researchers at Children’s Hospital Los Angeles studied 11 biomarkers associated with inflammation, bone loss and/or bone formation in about 450 individuals – assessed by sex and HIV status – to try to determine causes of this differential bone loss.
Fetal interventionists and pediatric cardiologists perform an “in utero atrial septal stent procedure” to open the atrium, allowing blood trapped in the lungs and left upper heart chamber of a HLHS fetus to flow back to the right side of the heart. The successful procedure was a first for the CHLA-USC Institute for Maternal-Fetal Health and a first for a Southern California hospital.
Robert Seeger, MD, division head for Basic and Translational Research of the Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA) has been selected for the 2016 Lifetime Achievement Award from the Pediatric Blood and Marrow Transplant Consortium (PBMC).
Children’s Hospital Los Angeles (CHLA) and Thermo Fisher Scientific have agreed to develop a next-generation sequencing (NGS)-based panel designed specifically for pediatric cancer research. The assay would be CHLA’s first NGS panel designed to target biomarkers associated with childhood cancers.
Investigators at The Saban Research Institute of Children’s Hospital Los Angeles have created a novel model for studying a lung disorder of newborn babies.
The Care+Cure initiatives of The Epilepsy Foundation of Greater Los Angeles have stated their intent to establish a $1.6 million endowment to fund The Pediatric Epilepsy Fellowship Program at Children’s Hospital Los Angeles (CHLA). This endowment, announced on International Epilepsy Day, will be used to launch a program in July 2016 that will train one epilepsy fellow every year in perpetuity.
Investigators at Children’s Hospital Los Angeles have found that significant bone loss – a side effect of chemotherapy for acute lymphoblastic leukemia (ALL) – occurs during the first month of treatment, far earlier than previously assumed. Results of the study will be available online February 4, in advance of publication in the journal Bone.
CHLA has named Jaclyn Biegel, PhD, a leading academic expert on pediatric brain tumors, rhabdoid tumors and cancer cytogenetics, as director of the Center for Personalized Medicine at CHLA.
An interdisciplinary research team at The Saban Research Institute of Children’s Hospital Los Angeles has found that body mass index (BMI) is an inadequate method for estimating changes in body fat and obesity in children with leukemia.
Researchers at Children’s Hospital Los Angeles have shown that an immunotherapy that until now has only been available to patients enrolled in research studies, is equivalent to the product that has been manufactured for commercial use and can be made available to all patients
Building on a 30-year, three-generation study of depressed individuals, their children and offspring, a study provides a better understanding of the familial risk for depression and the role neuroplasticity might have in increasing the risk of developing depression.
Financier and philanthropist Tom Gores and his wife Holly have made a $5 million commitment to establish a new pediatric allergy treatment center at Children’s Hospital Los Angeles.
Tracy Zaslow, MD, is the director of the Sports Concussion Program and medical director of of the Sports Medicine Program at Children's Hospital Los Angeles. She is Board-Certified in pediatrics, and also fellowship-trained, with board certification in sports medicine. Her clinical interests include a spectrum of orthopaedic and medical conditions affecting young athletes, including sports-related concussion, overuse injuries and injury prevention. Dr. Zaslow, a team physician for the L.A. Galaxy soccer team, understands the goals and challenges faced by young athletes because, like her patients, she grew up playing sports and still remains active in tennis, volleyball, running, hiking, yoga and skiing.
Children’s Hospital Los Angeles announces the availability of the EOS Imaging System, the first technology capable of providing head-to-toe images of patients in both 2D and 3D while using up to 90 percent less radiation than X-rays.
In the first study of its kind, researchers have shown that inadequate maternal iron intake during pregnancy exerts subtle effects on infant brain development. Their findings have been published online by the journal Pediatric Research.
The Leapfrog Group has named Children’s Hospital Los Angeles as a Leapfrog Top Hospital for 2015. The designation is considered one of the hospital industry’s elite benchmarks of patient safety and quality care and Children’s Hospital Los Angeles is the only pediatric medical center in Los Angeles County to receive the distinction.
Fans can bid on ornaments signed by Heidi Klum, Drew Barrymore, Bradley Cooper, Josh Gad, LL Cool J, Selena Gomez, Adam Levine, Gwen Stefani, Chris O’Donnell, Pharrell Williams, Sarah Chalke, Caitlyn Jenner, Kylie Jenner and Speck iPad Air cases signed by Spike Lee, Jack Black, Kevin Bacon, James Franco, Ryan Reynolds and Connie Britton, among others
Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger. This can make it difficult for an individual with ASD to successfully navigate social situations and empathize with others.
Children’s Hospital Los Angeles (CHLA) announced tthat it has been recognized as a Top Performer on Key Quality Measures® for 2015 (based on 2014 data) for its childhood asthma care by the Joint Commission, the leading accreditor of health care organizations in the United States.
Throughout her childhood, Blanca's doctors couldn't figure out why she had an enlarged liver, diagnosing her with everything from cirrhosis to hepatitis. But when she was referred to CHLA, cardiologist Dr. Frank Ing discovered the problem wasn't her liver at all. (Video Available)
Starting today and extending through the end of the year, CHLA's Live L.A. Give L.A. campaign raises funds that will directly support care for the children of Los Angeles. Providing the finest pediatric medical care and research comes with an immense cost—and the needs are urgent. A gift to the Live L.A. Give L.A. campaign helps safeguard the community’s sickest children by providing the support that the nonprofit pediatric hospital needs to conduct leading-edge research and ensure that critical, lifesaving care is available to every child the hospital treats.
Investigators at Children’s Hospital Los Angeles now report that platinum-based chemotherapy may not only impact hearing, but that the hearing loss may then contribute to long-term neurocognitive deficits.
A unique study at Children’s Hospital Los Angeles of newborns treated with hypothermia for hypoxic-ischemic encephalopathy (HIE) – a condition that occurs when the brain is deprived of an adequate oxygen supply – confirms its neuroprotective effects on the brain.
A study by scientists at Children’s Hospital Los Angeles has shown that tissue-engineered colon derived from human cells is able to develop the many specialized nerves required for function, mimicking the neuronal population found in native colon.
In a study to be published on Oct.1 by the journal Pediatric Emergency Care, investigators at Children’s Hospital Los Angeles piloted a brief mental health screening tool to be used with patients accessing the emergency department for medical complaints who might be at risk for mental health problems.
A team of researchers from the Trauma Program at Children’s Hospital Los Angeles conclude that an admission hematocrit provides a reliable screening test for identifying pediatric patients who are at an increased risk of bleeding after injury.
Investigators at Children’s Hospital Los Angeles have found that a common therapeutic target for the treatment of inflammatory bowel disease (IBD) may actually protect against intestinal inflammation by inhibiting pathogenic T-cells.
The Margie and Robert E. Petersen Foundation has announced it will make a $2.5 million unrestricted gift to support The Vision Center at Children’s Hospital Los Angeles in its efforts to advance medical teaching techniques, increase infrastructure for groundbreaking research and use cutting-edge video technology to reach more patients in less time.
Researchers led by Bradley S. Peterson, MD, director of the Institute for the Developing Mind at Children’s Hospital Los Angeles, have shown that lower levels of conflict-related brain activity are associated with a higher risk for later psychosis. The study, in conjunction with colleagues at Columbia University, is available via PubMed in advance of publication by the journal Neuropsychopharmacology.
Children’s Hospital Los Angeles has added four Xenex Germ-Zapping Robots to its team. Each uses UV-C light to disinfect rooms and destroy pathogens, including Clostridium difficile, norovirus and MRSA.
Researchers at Children’s Hospital Los Angeles have received an $8.4 million grant from the National Institutes of Health (NIH) to conduct research to improve HIV care and prevention in a study focusing on Black, Latino and multiracial gay and bisexual young men – a group at the highest risk for contracting HIV.
A life-changing event for a Los Angeles family has resulted in their funding an endowment to support The Kort Family Foundation Brain and Spinal Cord Tumor Research Program in the Division of Neurosurgery at Children’s Hospital Los Angeles.
Cardiologists from Children’s Hospital Los Angeles successfully implanted a Melody Transcatheter Pulmonary Valve in child actor Max Page, the boy who made headlines playing mini Darth Vader in a 2011 Super Bowl ad for Volkswagen. On Tuesday, Sept. 1, Max will have a procedure at Children’s Hospital Los Angeles to replace his pacemaker pulse generator. It will be his second operation in 34 days.
Sports medicine specialists from the Children’s Hospital Los Angeles Children’s Orthopaedic Center administered baseline concussion tests to 98 athletes from the Los Angeles Kings High School Hockey League on Saturday, August 22 at the Children’s Hospital Los Angeles Valencia Outpatient Center.
Specialists at Children’s Hospital Los Angeles compiled a list of rules to remember on how to keep children safe and healthy as they return to school.
The NIH has awarded $5.7M for a multicenter study to evaluate the long-term outcomes of medical treatment for transgender youth. This study will provide evidence-based information on the impact, as well as safety, of hormone blockers and cross-sex hormone use in this population.
Dr. Marcy’s focus is on the emotional aspects of the new school year — the stress it causes for kids and parents. She has a model called The Six Rs of Returning to School: Rest, Routine, Responsibility, Reassure, Resist and Role Modeling. She talks about how to help children with the sudden overwhelm of transitioning from summer fun and later nights to resuming long days in the classroom and doing nightly homework. She is also an expert on kids’ socialization issues, like bullying (how parents should manage if their kid is the victim or if their kid is the bully), dealing with new teachers, adjusting to a new school.
Medulloblastoma, the most commonly occurring malignant brain tumor in children, can be classified into four subgroups—each with a different risk profile requiring subgroup-specific therapy. Currently, subgroup determination is done after surgical removal of the tumor.
Pasadena Magazine’s annual Top Doctors issue has recognized 85 physicians with privileges to practice at Children's Hospital Los Angeles. Many of the honorees are members of the Children's Hospital Los Angeles Medical Group and are academically affiliated with the Keck School of Medicine of the University of Southern California.
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