Connecting Research and Experts with Journalists

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Treatment and “cure” of breast cancer doesn’t ensure that the disease won’t spread to the brain. Too often, sometimes years after an initial diagnosis and remission, breast cancer cells are discovered growing as new tumors within the brain. Now City of Hope researchers have found how this happens.

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A team of researchers at City of Hope has developed a screening assay that can quickly assess up to 1,536 compounds’ effect on estrogen activity in the body. The test can also evaluate whether chemicals act as inhibitors of aromatase, an enzyme linked to breast cancer that converts androgen to estrogen.

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A team of City of Hope researchers, lead by Yani Lu, Ph.D., found that a parent’s age at birth, particularly a father’s age, may affect the adult-onset cancer risk for daughters — especially for breast cancer.

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City of Hope researchers found that menopausal hormone therapy use is linked to a lower risk of B-cell non-Hodgkin lymphoma.

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A novel compound, COH-SR4, synthesized at City of Hope can target and treat drug-resistant lung cancers.

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City of Hope researchers found that a microRNA called miR-105 helps cancer metastasize by breaking down the building blocks of blood vessels' barriers, allowing the cancer cells to enter the bloodstream.

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PCNA is a protein essential to DNA repair and replication, and City of Hope researchers are targeting it in neuroblastoma cells in order to halt tumor growth and induce cell death.

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New City of Hope study finds that a cancer-prone mutation of the gene RECQ4 causes its corresponding enzyme, RECQ4, to accumulate in the mitochondria. This can cause mitochondrial dysfunction, possibly explaining cancer's "Warburg effect" of preferring lactic acid fermentation over aerobic respiration to generate energy.

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New research from City of Hope has found that stimulating a specific gene could prompt growth – in adults – of new neurons in this critical region, leading to faster learning and better memories.

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Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine’s biggest challenges: brain cancer. This month, they will launch a clinical trial using patients’ own modified T cells to fight advanced brain tumors.