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Genome Architecture Caught in Motion

Researchers at The Wistar Institute have uncovered new aspects of the three-dimensional organization of the genome, specifically how the genetic material is compacted and de-compacted in a timely fashion during the different phases of the cell cycle.
9-Oct-2017 11:05 AM EDT Add to Favorites

NIH Selects Wistar Scientist Kavitha Sarma, Ph.D., for New Innovator Award

The Wistar Institute, an international leader in biomedical research in the fields of cancer, immunology and infectious diseases, announces Kavitha Sarma, Ph.D., assistant professor in Wistar’s Gene Expression and Regulation Program, has been...
5-Oct-2017 1:05 PM EDT Add to Favorites

Characterization of a Slowly Proliferating Population of Melanoma Cells with High Metastatic Properties

A study conducted at The Wistar Institute has led to the identification of a slowly proliferating and highly invasive melanoma cell subpopulation, characterized by production of a protein associated with invasive behavior.
20-Sep-2017 11:05 AM EDT Add to Favorites

Tumor-infiltrating B Lymphocytes Promote Melanoma Progression and Resistance to Therapy

In a multi-institutional collaborative study, scientists at The Wistar Institute and the Medical University of Vienna, Austria, have identified the role of tumor-infiltrating or tumor-associated B-cells (“TABs”) in melanoma progression and...
19-Sep-2017 12:05 PM EDT Add to Favorites

A Newly Identified Mitochondrial Metastasis Suppressor Pathway Controls Metabolic Reprogramming of Tumor Cells

A novel mitochondrial variant of the protein Syntaphilin, or SNPH, which orchestrates the choice between cancer cell proliferation and metastasis in response to oxygen and nutrient shortage in the tumor microenvironment, has been identified by...
8-Sep-2017 1:05 PM EDT Add to Favorites

Modulating T-Cell Metabolism Uncovers New Technology for Enhancing Immunotherapy

T lymphocytes found in tumors and implicated in killing tumor cells cope with the shortage of oxygen and nutrients in the tumor microenvironment by using fat as the main source of energy. Promoting a switch from glucose to fatty acid to generate...
9-Sep-2017 7:00 PM EDT Add to Favorites

New Link Established Between a Molecular Driver of Melanoma Progression and Novel Therapeutic Agent

Wistar scientists have described a correlation between a key melanoma signaling pathway and a novel class of drugs being tested in the clinic as adjuvant therapy for advanced melanoma, providing useful information for a more effective use of this...
6-Sep-2017 1:35 PM EDT Add to Favorites

Outstanding Investigator Grant Awarded to Dario C. Altieri, M.D., Wistar President and CEO

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The Wistar Institute is pleased to announce that distinguished scientist Dario C. Altieri, M.D., Wistar president and CEO and director of the Institute’s Cancer Center, has been awarded an Outstanding Investigator Grant (R35) by the National...
5-Sep-2017 10:05 AM EDT Add to Favorites

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