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Targeting Telomeres to Overcome Therapy Resistance in Advanced Melanoma

A study conducted at The Wistar Institute in collaboration with The University of Texas Southwestern Medical Center has demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma.
21-Mar-2018 10:10 AM EDT Add to Favorites


New Targeted Therapeutic Approach to Combat Ovarian Cancer

According to a new study by The Wistar Institute, EZH2 inhibitors that are currently in clinical development for hematological malignancies and solid tumors may be effectively targeted to epithelial ovarian cancers overexpressing the CARM1 protein.
9-Mar-2018 8:00 AM EST Add to Favorites

Fundamental Step Found in the Cellular Response to Stress Caused by Pathological and Pharmacological Insults

A new study conducted by researchers at The Wistar Institute revealed how a key protein residing in the endoplasmic reticulum (ER) helps cells respond to stress. This process is especially important for B cells to respond to severe stress conditions...
6-Mar-2018 11:05 AM EST Add to Favorites

The Wistar Institute Awarded More Than $1.4 Million to Create a Malaria Vaccine Through Synthetic DNA-Based Technology

Wistar is pleased to announce it has been awarded a $1,494,972 grant by the Bill & Melinda Gates Foundation to advance a DNA-based vaccine candidate for protection against malarial infection utilizing a synthetic DNA platform created in the lab of...
18-Jan-2018 11:05 AM EST Add to Favorites


When it Comes to Science, it’s a Small, Small World

Immortalized human skin cells that look like a psychedelic otherworldly galaxy and a living algae colony releasing its daughter colonies that could be mistaken for Pacman gobbling up ghosts are just two of the winning images from the 2017 Nikon...
17-Jan-2018 12:05 PM EST Add to Favorites

Novel Combination Therapy Shown to Be Effective in Ovarian Cancer

Wistar researchers have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations.
19-Dec-2017 11:00 AM EST Add to Favorites

Scientists Identify Mechanism of Impaired Dendritic Cell Function that Weakens Immune and Therapeutic Response to Cancer

Wistar scientists revealed the mechanism implicated in the defective function of tumor-associated dendritic cells (DCs), a specialized type of immune cells that expose the antigens on their surface to activate the T cells
14-Dec-2017 3:10 PM EST Add to Favorites

Scientists Identified a Cellular Network That “Short Circuits” the Antitumor Effect of Novel Immunotherapy

Wistar researchers discovered a novel form of crosstalk among tumor cells and other cell types in the tumor microenvironment, elucidating the mechanism of action of an immunotherapeutic strategy that inhibits tumor-associated macrophages (TAMs) and...
10-Nov-2017 2:05 PM EST Add to Favorites

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