Research Alert

A Missing Piece of the Heart Regeneration Puzzle Discovered

Stem cell scientists make new inroads toward repairing heart attack damage and restoring function


  • newswise-fullscreen A Missing Piece of the Heart Regeneration Puzzle Discovered

    Credit: UW Medicine Institute for Stem Cell and Regenerative Medicine

    Magnification of human stem-cell derived heart muscle cells called cardiomyocytes stained for contractile proteins (red, green and yellow) and DNA (blue)

  • newswise-fullscreen A Missing Piece of the Heart Regeneration Puzzle Discovered

    Credit: UW Medicine Institute for Stem Cell and Regenerative Medicine

    Magnification of human stem-cell derived heart muscle cells to show contractile proteins.

A new finding in heart regeneration could lead to more effective treatments for heart disease. The study at the University of Cambridge and the University of Washington showed that injecting a mixture of cardiac muscle cells plus epicardial-derived cells enhanced heart regeneration in rats. A Nature Biotechnology paper says the mixture built larger muscle grafts with better blood vessels compared to either cell type alone. This markedly enhanced cardiac function. The epicardium is the outer, protective layer of the heart wall. Its cells play a role in heart development and later in injury response.

 

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