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Newswise: $4.96 Million CIRM Grant Awarded to Sanford Burnham Prebys to Help the Tiniest Patients

Article ID: 717535

$4.96 Million CIRM Grant Awarded to Sanford Burnham Prebys to Help the Tiniest Patients

Sanford Burnham Prebys Medical Discovery Institute

The California Institute for Regenerative Medicine (CIRM) has awarded a $4.96 million grant to Sanford Burnham Prebys Professor Evan Y. Snyder, M.D., Ph.D. The funding will allow Snyder to complete pre-investigational new drug (IND)-enabling studies, a step toward securing U.S. Food & Drug Administration (FDA) approval of a human trial for neural stem cells as a potential treatment for newborns who experience oxygen and blood-flow deprivation during birth. Called perinatal hypoxic-ischemic brain injury (HII), the lack of oxygen and blood flow to the brain can cause cerebral palsy and other permanent neurological disorders.

Released:
19-Aug-2019 8:00 AM EDT
Newswise: A Simple Method to Improve Heart-Attack Repair Using Stem Cell-Derived Heart Muscle Cells

Article ID: 717122

A Simple Method to Improve Heart-Attack Repair Using Stem Cell-Derived Heart Muscle Cells

University of Alabama at Birmingham

The heart cannot regenerate muscle after a heart attack. Injecting heart muscle cells grown in vitro could help the failing heart, but engraftment rates are low. A new and simple method to improve the quality of the delivered cells has now been tested in mice, and it doubles the engraftment rate.

Released:
7-Aug-2019 4:05 PM EDT
Newswise: Functional Hair Follicles Grown from Stem Cells
  • Embargo expired:
    27-Jun-2019 4:55 PM EDT

Article ID: 714917

Functional Hair Follicles Grown from Stem Cells

Sanford Burnham Prebys Medical Discovery Institute

Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.

Released:
25-Jun-2019 2:00 PM EDT
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Article ID: 714623

Scaffold Helps Cells Repair Torn Meniscus in Lab Tests

Duke Health

About a million times a year, Americans with a torn meniscus get surgery, but certain tears don't heal well. Duke scientists have developed a scaffold from a pig’s meniscus that performed better in lab tests than healing without a scaffold.

Released:
19-Jun-2019 1:05 PM EDT
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Article ID: 712527

Research Team Finds New Ways to Generate Stem Cells More Efficiently

University of Wisconsin-Madison

A new study published in Cell Reports by a team of researchers at the University of Wisconsin–Madison’s Wisconsin Institute for Discovery and School of Medicine and Public Health could improve the efficiency of creating induced pluripont stem cells.

Released:
7-May-2019 4:05 PM EDT
  • Embargo expired:
    7-May-2019 11:00 AM EDT

Article ID: 712406

New Approach Shows Regeneration of Severely Damaged Lungs

Columbia University School of Engineering and Applied Science

Researchers have—for the first time—demonstrated in a clinically relevant model that severely damaged lungs can be regenerated to meet transplantation criteria. Their new study describes the cross-circulation platform that maintained the donor lung’s viability and function and the recipient’s stability for 36-56 hours. Current methodologies of lung support are limited to only 6-8 hours, a time too short for therapeutic interventions that could regenerate the injured lung and improve its function.

Released:
6-May-2019 12:00 PM EDT
Newswise: DISCOVERing Off-Target Effects for Safer Genome Editing
  • Embargo expired:
    18-Apr-2019 2:00 PM EDT

Article ID: 711380

DISCOVERing Off-Target Effects for Safer Genome Editing

Innovative Genomics Institute

The CRISPR-Cas9 genome editing system cuts DNA at exactly where scientists specify, but sometimes it cuts at “off-target” sites too. In an upcoming Science paper, researchers reveal DISCOVER-Seq, an unbiased method that uses a DNA repair protein to identify all Cas9 cut sites. This approach gives genome editors a clearer picture of how safe their nascent CRISPR therapies really are.

Released:
15-Apr-2019 5:00 PM EDT
Newswise: Researchers Use Gene Editing with CRISPR to Treat Lethal Lung Diseases before Birth
  • Embargo expired:
    17-Apr-2019 2:00 PM EDT

Article ID: 710797

Researchers Use Gene Editing with CRISPR to Treat Lethal Lung Diseases before Birth

Children's Hospital of Philadelphia

Researchers used CRISPR gene editing to thwart a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.

Released:
14-Apr-2019 7:00 PM EDT

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