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Article ID: 712527

Research Team Finds New Ways to Generate Stem Cells More Efficiently

University of Wisconsin-Madison

A new study published in Cell Reports by a team of researchers at the University of Wisconsin–Madison’s Wisconsin Institute for Discovery and School of Medicine and Public Health could improve the efficiency of creating induced pluripont stem cells.

7-May-2019 4:05 PM EDT
  • Embargo expired:
    7-May-2019 11:00 AM EDT

Article ID: 712406

New Approach Shows Regeneration of Severely Damaged Lungs

Columbia University School of Engineering and Applied Science

Researchers have—for the first time—demonstrated in a clinically relevant model that severely damaged lungs can be regenerated to meet transplantation criteria. Their new study describes the cross-circulation platform that maintained the donor lung’s viability and function and the recipient’s stability for 36-56 hours. Current methodologies of lung support are limited to only 6-8 hours, a time too short for therapeutic interventions that could regenerate the injured lung and improve its function.

6-May-2019 12:00 PM EDT
  • Embargo expired:
    18-Apr-2019 2:00 PM EDT

Article ID: 711380

DISCOVERing Off-Target Effects for Safer Genome Editing

Innovative Genomics Institute

The CRISPR-Cas9 genome editing system cuts DNA at exactly where scientists specify, but sometimes it cuts at “off-target” sites too. In an upcoming Science paper, researchers reveal DISCOVER-Seq, an unbiased method that uses a DNA repair protein to identify all Cas9 cut sites. This approach gives genome editors a clearer picture of how safe their nascent CRISPR therapies really are.

15-Apr-2019 5:00 PM EDT
  • Embargo expired:
    17-Apr-2019 2:00 PM EDT

Article ID: 710797

Researchers Use Gene Editing with CRISPR to Treat Lethal Lung Diseases before Birth

Children's Hospital of Philadelphia

Researchers used CRISPR gene editing to thwart a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.

14-Apr-2019 7:00 PM EDT

Article ID: 710788

Researchers Show That Mutations in Human Livers Can Promote Tissue Regeneration

UT Southwestern Medical Center

Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified genetic mutations that accumulate in the adult liver that can promote regeneration in the context of chronic liver damage.

4-Apr-2019 12:05 PM EDT
  • Embargo expired:
    28-Mar-2019 11:00 AM EDT

Article ID: 710062

Cultured Stem Cells Reconstruct Sensory Nerve and Tissue Structure in the Nose

Tufts University

Researchers have developed a method to grow and maintain olfactory stem cells. The work is a launch pad for developing stem cell transplantation therapies or pharmacologic activation of a patient’s own dormant cells, to restore the sense of smell where it has been damaged by injury or degeneration.

21-Mar-2019 5:00 PM EDT

Article ID: 710258

Fatty Tissue from Abdomen Could Regenerate Heart, Protect It from Failure

Ann and Robert H. Lurie Children's Hospital of Chicago

The nondescript yet mysterious fatty tissue that hangs like an apron from the stomach – called the omentum – holds great promise for thousands of children born with hypoplastic left heart syndrome(HLHS) or other severe cardiac defects, who might need a heart transplant within their first 10 years of life. Using an animal model, researchers found that surgically attaching the omentum to the overburdened heart reduces signs of injury, allowing the heart to function normally. Their findings were published in the Annals of Thoracic Surgery.

26-Mar-2019 4:05 PM EDT
  • Embargo expired:
    24-Jan-2019 1:00 PM EST

Article ID: 706763

Sci-Fi to Reality: Superpowered Salamander May Hold the Key to Human Regeneration

University of Kentucky

Scientists at the Unviersity of Kentucky have assembled the entire genome of the Mexican Axolotl, the key to unlocking the secrets of regeneration with potential for life-changing clinical applications down the road.

18-Jan-2019 4:00 PM EST
  • Embargo expired:
    5-Dec-2018 1:00 PM EST

Article ID: 704900

Scientists Design Way to Track Steps of Cells’ Development

Washington University in St. Louis

Scientists at Washington University School of Medicine in St. Louis have developed a new tool described as a “flight data recorder” for developing cells, illuminating the paths cells take as they progress from one type to another. This cellular tracking device could one day help scientists guide cells along the right paths to regenerate certain tissues or organs, or help study the origins of cancer.

4-Dec-2018 1:05 PM EST

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