George T. Grossberg, M.D., and colleagues were instrumental in developing the first and only Food and Drug Administration (FDA) approved treatment for agitation associated with Alzheimer's dementia.
A team of researchers from The University of Texas at El Paso found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.
Researchers at the University of Wisconsin–Madison have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer’s and Parkinson’s diseases and used the discovery to grow the neurons from stem cells for the first time.
A new MIT study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer’s pathology in other ways
McWilliams School of Biomedical Informatics at UTHealth Houston reached a funding landmark with 15 faculty members awarded 16 different grants totaling more than $31 million between August and October 2023. Each grant has a focus on medical artificial intelligence (AI) innovations and advancements in research or health care.
With the rise of new drugs that can target the amyloid-beta plaques in the brain that are an early sign of Alzheimer’s disease, new ways are needed to determine whether memory loss and thinking problems are due to Alzheimer’s disease or another neurodegenerative disorder. A new study published in the November 15, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology, shows that shrinkage in the hippocampus area of the brain is associated with cognitive decline, even in people who don’t have amyloid plaques in the brain. The hippocampus plays a role in memory.
As part of a five-year, $3.9 million grant from the National Institutes of Health, Adriana Pérez, PhD, professor in the Department of Biostatistics and Data Science with UTHealth Houston School of Public Health in Austin, received a $1.9 million subcontract to determine the scope and drivers of low-value and unequal care for patients with Parkinson’s disease and Parkinson’s disease dementia.
Alzheimer’s disease slowly erases memories and cognitive abilities, upending families ― and it’s incurable. But there are steps you can take to slow and prevent it, says a Penn State Health expert.
Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer’s disease.
An international team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer’s and Parkinson’s Diseases. The biosensor can also transmit the results wirelessly to a laptop or smartphone.
Researchers led by Mroj Alassaf at the Fred Hutchinson Cancer Research Center in the United States have discovered a link between obesity and neurodegenerative disorders like Alzheimer’s disease.
People who have a higher biological age than their actual chronological age have an increased risk of stroke and dementia. The findings suggest that by slowing down the body's aging processes, it may be possible to reduce or delay the onset of disease.
Investigators from the Department of Neurosurgery at Cedars-Sinai have determined that exposure to polluted air could accelerate development of Alzheimer’s disease in those with genetic risk factors for the neurodegenerative condition.
Mount Sinai researchers have shed valuable light on the mechanism of a key protein that regulates the plasticity and function of the hippocampus, a key brain region involved in memory and learning, and that decreases with age in mice.
Case Western Reserve University has established an Institute for Glial Sciences to advance research of glial cells and their critical role in the health and diseases of the nervous systems, including multiple sclerosis, Alzheimer’s, pediatric leukodystrophies, Autism spectrum disorders, Parkinson’s disease and cancer.
Wake Forest University School of Medicine and Atrium Health Wake Forest Baptist, the academic core of Advocate Health, are launching their largest campaign for research. Designed with health equity at the forefront, funds raised in this campaign will transform health care for patients, communities and the next generation of health care leaders by integrating research with clinical care while enhancing the speed with which new ideas move from research labs to patients' bedsides and beyond.
In a detailed study published in the Journal of Alzheimer’s Disease November 3, 2023, we can finally see which diets are helpful in reducing the risk of developing Alzheimer’s disease.
For clinical trials centered on individuals with Alzheimer’s disease and related dementias, what types of information are family caregivers given during the research process? A research team nested in the College of Applied Health Sciences recently evaluated that question by analyzing ADRD trials from the past 30 years.
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Building upon the expertise in dementia research and care across Penn Medicine, the health system has been awarded a $5 million grant from the Delaware Community Foundation to support the Penn Institute on Aging’s (IOA) work to develop the next generation of therapies for Alzheimer’s disease and related dementias (ADRD).
Researchers at Indiana University School of Medicine will play key roles in a national consortium led by Wake Forest University School of Medicine to study the use, interpretation and implementation of biomarkers to diagnose Alzheimer's disease. The multi-institution effort is funded by a five-year, $9 million grant from the National Institute on Aging, part of the National Institutes of Health, that will establish the Alzheimer's Diagnosis in Older Adults with Chronic Conditions (ADACC) Network.
Up to 1.7 million people could be living with dementia in England and Wales by 2040 – over 40% more than previously forecast – finds a new UCL-led study.
Older people who have higher levels of triglycerides, a type of fat, may have a lower risk of dementia and a slower cognitive decline over time compared to people who have lower levels, according to new research published in the October 25, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Two new USC Dornsife studies suggest that of the 8 million Americans who have MCI, more than 90% don’t know it — an especially worrisome finding since early diagnosis is key to delaying onset of dementia and Alzheimer’s disease
Researchers at Wake Forest University School of Medicine have received a five-year, $9 million grant from the National Institute on Aging, part of the National Institutes of Health, to create a national consortium that will study the use, interpretation and implementation of biomarkers to diagnose Alzheimer's disease.
For the first time, a Cornell University-led study in rats teases apart the role of the hippocampus in two functions of memory – one that remembers associations between time, place and what one did, and another that allows one to predict or plan future actions based on past experiences.
A five-year, $6.4 million grant to develop an integrated, multiscale artificial intelligence (AI) approach to study genetic factors associated with Alzheimer’s disease has been awarded to UTHealth Houston by the National Institute on Aging, part of the National Institutes of Health.
A study spent 50 years tracking the health of a rural Louisiana town's children into adulthood and found that heart disease starts in childhood. Now the study hopes decades of heart research can unlock the origins of dementia.
Most people think of dementia as something that affects a person’s brain. But a new study shows just how much damage it does to a person’s wallet and bank account too – as well as the higher demands it places on their family members -- compared with people of the same age in similar health but without dementia.
In a large, multi-institutional effort led by University of California San Diego, researchers have analyzed more than a million human brain cells and revealed links between specific types of cells and various common neuropsychiatric disorders.
A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Pathways explaining racial/ethnic and socio-economic disparities in dementia incidence: the UK Biobank study.”
Among people who report memory and thinking problems, some show no signs of a problem on standard tests, while others have subtle declines on their tests. A new study shows that people who have subtle problems with these tests may have an increased risk of developing mild cognitive impairment, which can be a precursor to dementia. The study is published in the October 11, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
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The Board of Governors named Michal Schnaider Beeri, a global leader in Alzheimer’s disease clinical research and director of the Herbert and Jacqueline Krieger Klein Alzheimer’s and Dementia Clinical Research and Treatment Center, as its Endowed Chair in Neurodegenerative Research.
To address the growing disparity and identify multi-level risk factors impacting the higher prevalence of Alzheimer’s disease among middle-aged and older Black adults, Corewell Health neuroscientist Stewart Graham, Ph.D., in collaboration with researchers from Hampton University, Johns Hopkins and Clemson are spearheading a first-of-its-kind, five-year, $4.8 million research project.
The brain circuitry that is disrupted in Alzheimer’s disease appears to influence memory through a type of brain wave known as theta oscillation, a team led by UT Southwestern Medical Center researchers report. The findings, published in Nature Communications, could help researchers design and evaluate new treatments for Alzheimer’s, a condition that affects millions of people around the globe and has no cure.
Sixty percent of patients with dementia on autopsy studies have cerebral amyloid angiopathy (CAA) pathology. This episode discusses the relationship between CAA and epilepsy through the lens of a recent publication. Dr. Alina Ivaniuk talks with Dr. Brin Freund.
Until recently, our understanding of Parkinson's disease has been quite limited, which has been apparent in the limited treatment options and management of this debilitating condition.
Researchers from Karolinska Institutet have published a study in Alzheimer's Research & Therapy that addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer’s disease.
Fueled by new five-year funding expected to total $81 million from the NIH’s National Institute on Aging, a multi-institution team will work to improve understanding of the health care workforce that cares for people with dementia, through surveys and other methods that will produce data for clinicians, researchers, policymakers and others to use.
The Resource Center for Alzheimer’s and Dementia Research in Asian and Pacific Americans will work to advance behavioral, social and economic research related to Alzheimer’s disease and other dementias especially in older Asian and Pacific Americans.
The work of principal investigator Alberto Ramos, M.D., M.S., underscores the importance of sleep studies for a group that has an elevated risk for Alzheimer’s disease.
The cyanobacterial origin of β-N-methylamino-L-alanine (BMAA), an environmental neurotoxin, remains controversial. With a carefully designed genetic system as a control, we found no evidence for the production of BMAA by cyanobacteria from lab cultures or bloom samples.
It is well known that sleep is the best medication. However, it is still unknown why the brain recovers better in sleep and whether these processes can be controlled.