ISU researchers have found evidence that a “housekeeping” gene present in every cell of the body may have a link to male infertility. The results of the study suggest that deficiency of the SMN gene could have different effects in males and females.
Research from Indiana University published in the Proceedings of the National Academy of Sciences has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.
The ever-shrinking cost of DNA sequencing improves accessibility for an increasing number of people and, importantly, for the diagnosis and treatment of disease. This is particularly salient in cancer genetics, as cancer is often the result of mutation in not one gene, but many. Moreover, personalized genomics is the foundation of precision medicine; however, having the DNA sequence in hand is only half of the equation.
For the first time, researchers have treated an animal model of a genetic disorder using a viral vector to deliver genome-editing components in which the disease- causing mutation has been corrected. Delivery of the vector to newborn mice improved their survival while treatment of adult animals, unexpectedly, made them worse.
MaxMind, an industry-leading provider of IP security and online fraud detection tools, has given a $100K gift to the George Washington University’s Research Center for Neglected Diseases of Poverty to end schistosomiasis through gene drive technology.
From a collection of more than 7,800 unrelated neurofibromatosis type 1 mutations, UAB researchers have aimed at two goals: correlate a particular mutation with the symptoms that will develop as the child grows, and identify the likely mechanism that caused a group of DNA rearrangement mutations.
Researchers found a way of differentiating angiocentric gliomas from other low-grade pediatric brain tumors and developed a pathological test that will help children avoid unnecessary and potentially damaging additional therapies.
A new study evaluated the relationship between common genetic variants implicated in schizophrenia and those associated with subcortical brain volumes, and found no evidence of genetic overlap between schizophrenia risk and subcortical volume measures.
Groundbreaking work is the result of analytical ingenuity, fortuitous collaborations, and catalytic philanthropic funding.
An international coalition of researchers led by Oklahoma Medical Research Foundation scientist Swapan Nath, Ph.D., has identified 10 new genes associated with the autoimmune disease lupus. The findings were published in the Jan. 25 issue of Nature Genetics.
Expert can discuss recent advances in the science of bioanalytics and molecular information, that let us identify and characterize the products of all living cells—including proteins, lipids, metabolites and nucleic acids. He can specifically focus on how this technology is becoming a key driver in basic research, pharmaceutical development and clinical medicine.
A new study by researchers at Boyce Thompson Institute (BTI) has uncovered a veritable trove of genes used by plants to form symbiotic relationships with fungi, vastly increasing the knowledge of the genetic basis for this agriculturally valuable interaction.
A new clinical study published in the January issue of Gene Therapy reports the promising results of an innovative DNA-based gene therapy that may offer a potential therapeutic option for a disease with unmet medical needs.
The study, “Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord,” published December 18, 2015, in PLOS Genetics, analyzes the regions of DNA that switch on gene expression in the notochord, called notochord cis-regulatory modules (CRMs, also known as enhancers). The paper presents a systematic analysis of CRMs that share the distinctive property of turning on gene expression in the notochord.
A pair of studies by a team of scientists has shed new light on the nature of a particular type of DNA sequences—tandem DNA repeat arrays—that play important roles in transcription control, genome organization, and development.
A comprehensive analysis of the molecular characteristics of gliomas—the most common malignant brain tumor—explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.
A protein called XPG plays a previously unknown and critical role helping to maintain genome stability in human cells. It may also help prevent breast, ovarian, and other cancers associated with defective BRCA genes.
A provocative study by evolutionary biologists at McMaster University takes on one of Charles Darwin’s central ideas: that males adapt and compete for the attention of females because it is the females who ultimately choose their mates and the time of mating.
Scientists have used a new gene-editing technology called CRISPR, to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition that causes the retina to degrade and leads to blindness in at least 1.5 million cases worldwide.
Andean beans (for example, red kidney beans) were overlooked by researchers because other beans were easier to breed. However, researchers took notice of the Andean bean. They recognized its potential to play a role in feeding the world.
Coastal seagrass ecosystems cover some 200,000 square kilometers and account for an estimated 15 percent of carbon fixed in global ocean. In Nature, a team including DOE Joint Genome Institute researchers describes the first marine angiosperm genome: the eelgrass Zostera marina.
A gene that is often lost in childhood cancer plays an important role in the decision between life and death of certain cells, according to a new study published in the journal Developmental Cell. Researchers at Karolinska Institutet and Ludwig Cancer Research in Sweden have discovered the process by which that gene, KIF1B-β, kills cells and thereby suppresses tumour development.
A team of scientists has uncovered greater intricacy in protein signaling than was previously understood, shedding new light on the nature of genetic production.
The most commonly mutated gene in cancer, p53, works to prevent tumor formation by keeping mobile elements in check that otherwise lead to genomic instability, UT Southwestern Medical Center researchers have found.
Fertility experts in Southampton and the Netherlands have identified a specific genetic pattern in the womb that could predict whether or not IVF treatment is likely to be successful.
At least 60 genetic diseases called neurocutaneous disorders involve the skin, central nervous system, and/or peripheral nervous system, Loyola University Medical Center neurologists report.
As countries around the world seek to craft policy frameworks governing the powerful new genetic editing tool, policy makers need to determine 'thresholds of acceptability' for using the technology, according to three researchers from the Centre of Genomics and Policy at McGill University.
By harnessing the most advanced data-mining tools, Jackson Laboratory Professor Carol Bult is leading the hunt for suspect genes that contribute to a common, deadly birth defect.
Using a new computer science approach, researchers at University of California, San Diego School of Medicine, Columbia University and Stanford University discovered a distinctive molecular feature — a biomarker — that identified colon cancer patients who were most likely to remain disease-free up to five years after surgery. The biomarker, a protein called CDX2, also helped the researchers identify Stage II colon cancer patients who are most likely to benefit from chemotherapy after surgery.
Building on a 30-year, three-generation study of depressed individuals, their children and offspring, a study provides a better understanding of the familial risk for depression and the role neuroplasticity might have in increasing the risk of developing depression.
A single injection. That’s all someone with a factor VII deficiency would need for a life-long cure, thanks to a new gene therapy treatment developed in a collaboration of researchers at the University of North Carolina (UNC) and The Children’s Hospital of Philadelphia (CHOP).
This finding is key as UF/IFAS and other agencies conduct studies involving citizen scientists. Good entomological research often relies on collecting and preserving the genetic material in specimens.
Cancers evolve over time in patterns governed by the same natural laws that drive physical and chemical processes as diverse as the flow of rivers or the brightness of stars, a new study reports.
CRISPR/Cas9 gene editing technique can be transiently activated and inactivated using RNA-based drugs, giving researchers more precise control in correcting and inactivating genes.
Researchers show gene variant causes Hajdu-Cheney syndrome, may illuminate bone loss more generally.
New large-scale computational analysis of gene expression in single cells in the brain identifies distinct cell types.
Researchers at University of California, San Diego School of Medicine and Rady Children’s Hospital-San Diego have created the first stem cell-derived in vitro cellular model of a rare, but devastating, neurodegenerative condition called Cockayne syndrome (CS).
IDH mutations disrupt how the genome folds, bringing together disparate genes and regulatory controls to spur cancer growth.
A team of investigators based in Seattle, Amsterdam, and Luxembourg, have established the cause of a rare syndrome consistent with Fanconi Anemia, a chromosome instability disorder which is clinically typified by birth defects, bone marrow failure, leukemia, and susceptibility to solid tumors. The results were reported by researchers from the Institute for Systems Biology (Seattle), the Free University Medical Center in Amsterdam, and the Luxembourg Centre for Systems Biomedicine and several other institutions in the United States and Europe in the journal Nature Communications on December 18, 2015 (DOI: 10.1038/ncomms9829).
The Coriell Personalized Medicine Collaborative (CPMC), a research initiative exploring the utility of genetic information in the clinical setting, has published a study and identified six noteworthy genes that affect human sleep duration.
Patients between the ages of 40 and 70 who undergo aortic valve replacement (AVR) may fare better with tissue-based valves rather than metal-based valves
UCLA scientists have discovered that an overlooked region in brain cells houses a motherlode of mutated genes previously tied to autism. Recently published in Neuron, the finding could provide fresh drug targets and lead to new therapies for the disorder, which affects one in 68 children in the United States.
Research suggests we do not yet have the whole story about how fertilised eggs produce the many different types of cell that make up our adult bodies.
An analysis funded by the National Eye Institute (NEI), part of the National Institutes of Health, has identified three genes that contribute to the most common type of glaucoma. The study increases the total number of such genes to 15.
An international consortium of scientists has announced it has been able to crack the code for understanding the order of about 90 per cent of the highly complex genome of bread wheat, the most widely grown cereal in the world.
he J. Craig Venter Institute (JCVI) policy group today released a new report titled, “DNA Synthesis and Biosecurity: Lessons Learned and Options for the Future,” which reviews how well the Department of Health and Human Services guidance for synthetic biology providers has worked since it was issued in 2010.
Nearly every girl and woman on Earth carries two X chromosomes in nearly every one of her cells – but one of them does (mostly) nothing. That’s because it’s been silenced, keeping most of its DNA locked up and unread like a book in a cage. Scientists thought they had figured out how cells do this, but a new piece of research from the University of Michigan Medical School shows the answer isn’t quite that clear.
When sick, we assume that our aches, fever, etc., are from a virus or bacteria, but now a team of scientists have a novel hypothesis: evolution. The genes that trigger symptoms which encourage us to stay home are actually focused on their own survival – in the group as a whole, if not in us.
A UA researcher and clinician team has discovered that genetic mutations in a protein associated with asthma can affect a person’s susceptibility to a variety of lung diseases — and could lead to new treatments.
A single chance mutation caused an ancient protein to evolve a new function essential for multicellularity in animals, about a billion years ago, according to research co-led by UChicago scientists.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right