A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, “The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies.”
Lung cancer is the leading cause of death in Japan and across the globe. Among all the cancers, lung cancer has one of the lowest five-year survival rates.
An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.
Could knowing where your ancestors came from be the key to better cancer treatments? Maybe, but where would that key fit? How can we trace cancer’s ancestral roots to modern-day solutions?
High-calorie foods—high in fat, oil, and sugar—can taste good but often cause overeating, leading to obesity and major health problems. But what stimulates the brain to cause overeating?
UT Southwestern researchers have identified the molecular function of 87 inherited genetic variants that affect the risk of prostate cancer, and the majority appear to control the activity of genes located far away from the risk variants themselves.
The medical community has never researched the simultaneous impact of post-traumatic stress disorder (PTSD), traumatic brain injury (TBI), and genetic risk factors in a large cohort … until now.
For the first time, researchers at UC San Diego have shown that changes in gene expression happen almost entirely during the transcription stage while the cells are growing. The researchers have provided a simple quantitative formula linking regulatory control to mRNA and protein levels.
After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome — a rare genetic, neurocognitive disorder.
Whether radiation exposure of fathers can have consequences on their children is one of the most long-standing questions in radiation biology.
Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.
Researchers at the University of Tokyo have used artificial DNA to target and kill cancer cells in a completely new way.
Irvine, Calif., Dec. 21, 2022 — A research team led by the University of California, Irvine has linked the mutation that causes Huntington’s disease to developmental deficits in the brain’s oligodendrocyte cells that are caused by changes in metabolism. They found that high doses of thiamine and biotin can restore normal processes.
Researchers from Children’s Hospital of Philadelphia (CHOP) and New Jersey Institute of Technology (NJIT) developed new software that integrates a variety of information from a single cell, allowing researchers to see how one change in a cell can lead to several others and providing important clues for pinpointing the exact causes of genetic-based diseases.
Modern humans evolutionarily split from our chimpanzee ancestors nearly 7 million years ago, yet we are continuing to evolve.
New research findings have revealed an underlying genetic cause for why some children who have had COVID-19 infection develop Multisystem Inflammatory Syndrome in Children (MIS-C), a rare but potentially life-threatening disease. The findings, published in Science, are the first potential genetic cause identified for MIS-C, a disease that typically occurs about four weeks after COVID-19 infection and has broad symptoms such as fever, vomiting and inflammation of the heart muscle that can lead to hospitalization. States have reported about 9,000 MIS-C cases, with 71 deaths, according to most recent Centers for Disease Control and Prevention numbers.
Lukas Chavez, Ph.D., has joined Sanford Burnham Prebys as an assistant professor in the Tumor Initiation and Maintenance Program to continue his research on chromatin and gene regulation in childhood brain cancers.
Neuroscience graduate students at Children’s Hospital Los Angeles have developed an automated method that could save time and work for laboratories around the country by streamlining the process of identifying and mapping brain cells. Scientists want to understand how brain cells develop over time because the way these cells, called neurons, develop, influences how they function, or how they malfunction in neurodevelopmental disorders.
BioVU, Vanderbilt University Medical Center’s biobank, has reached another milestone — deep-freeze storage of more than 300,000 biological samples.
Sometimes a name is just a name. Take bears, for example. In Yellowstone National Park, black bears outnumber their brownish-colored grizzly bear cousins, and in coastal areas of the Pacific Northwest, if someone says “brown bear,” they mean grizzly bear. But not all brown bears are grizzly bears.
Rutgers researchers hope their genome-assembly tool will spur the development of new treatments for bacterial infections.
Scientists found that differences in the epigenome, in particular the DNA methylome, are predictably associated with differences in the temperament of dogs, especially their energy and fearfulness. The DNA methylome predicted these traits better than Single-Locus Polymorphisms or age. In future, breeders could screen the epigenome of puppies to find the best candidates for companion or service dogs.
Pancreatic cancer remains one of the deadliest malignancies worldwide.
Octopuses have captured the attention of scientists and the public with their remarkable intelligence, including the use of tools, engaging in creative play and problem-solving, and even escaping from aquariums.
Researchers at UC San Diego provide new insights into the pathology of limbic predominate age-related TDP-43 encephalopathy, which mimics Alzheimer’s, making it very difficult to identify in living patients.
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science led 70 participants from 14 nations in a discussion on the ways in which a gene drive project registry could both contribute to and detract from the fair development, testing and use of gene-drive modified organisms.
In a new scientific study, researchers at Uppsala University have shown that Scandinavian wolves carry around 100,000 harmful mutations in their genome.
Some patients with prostate cancer have genetic mutations that may impact their treatment. A comprehensive, on-site genetic testing program, pioneered by urologists, could help to close the gap for this underutilized resource, reports a study in Urology Practice®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.
A critical set of genes linked to successful racehorses has been identified by an international research team.
UC San Diego scientists identify a new molecular model and potential therapeutic target for gout, the most common form of inflammatory arthritis.
An international research team has provided valuable new information about what drives the global spread of genes responsible for antimicrobial resistance (AMR) in bacteria.
MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state.
A grasshopper hatched in a crowded environment may look and behave differently than a grasshopper hatched in isolation — even if they have the same genes.
Using models, researchers at UC San Diego School of Medicine, with colleagues elsewhere, describe using RNA-targeting CRISPR/Cas13d technology to develop a new therapeutic strategy that specifically eliminates toxic RNA that causes Huntington’s Disease.
A good night's sleep can work wonders for both mind and body. But what is it that determines how much we need to sleep, and what can cause us to sleep more deeply?
A new study led by Yves Brun shows how some bacteria living in a biofilm sacrifice themselves to ensure the survival of the community.
Study uncovers the genomic features of Richter's and how it emerges from CLL Researchers identify molecular subtypes of Richter's and y show that, in some cases, Richter's can be detected in a blood test, rather than a biopsy, potentially leading to earlier treatment.
In the vast oceans, one would assume their inhabitants can travel far and wide and, as a result, populations of a species would mix freely.
Patients with invasive breast cancer who had low scores on an investigational gene molecular signature had similar rates of local recurrence whether or not they received adjuvant radiation therapy after breast-conserving surgery.
Northwestern University researchers have discovered a previously unknown mechanism that drives aging.
From the excitable sheep dog to the aloof Shiba Inu, and all breeds in between, dogs have unique and diverse behavioral traits.
Florida State University College of Medicine researchers have linked aspartame, an artificial sweetener found in nearly 5,000 diet foods and drinks, to anxiety-like behavior in mice. Along with producing anxiety in the mice who consumed aspartame, the effects extended up to two generations from the males exposed to the sweetener.
Usually, the scariest part of childhood vaccination, for both kids and parents, is the needles. In rare cases, however, vaccines can have unexpectedly negative effects, and the secret lies in our genes.
Irvine, Calif., Dec. 8, 2022 — The National Academy of Inventors has named two University of California, Irvine researchers as fellows for 2022. Philip Felgner, a pioneer in the development of lifesaving mRNA vaccines, and Payam Heydari, a prolific creator of cutting-edge microelectronics technologies, were both recognized for inventions that have made tangible impact on quality of life, economic development and the welfare of society.
The American Neuromuscular Foundation (ANF), is excited to announce the 2022 Development Grant Recipient, Stefan Nicolau, MD, for his research project “CRISPR/Cas9 correction of a common Duchenne muscular dystrophy (DMD) deletion.” Dr. Nicolau is a research fellow at the Abigail Wexner Research Institute at Nationwide Children’s Hospital in Columbus, OH.
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