A UCLA-led study involving mice and human data could also have implications for individuals with diabetes and obesity, uncovering new treatment possibilities for life-threatening arrhythmias.
A protein called torsinA plays a key role in the early development of neurons, determining where nuclear pores are placed in the membrane that encloses the nucleus of nerve cells, a study led by UT Southwestern Medical Center researchers shows.
A pivotal study has decoded the genetic basis of olive oil production, revealing a key regulatory mechanism that shapes oil biosynthesis. By mapping the olive tree’s genome and metabolic pathways, researchers have identified how MYC2, a critical transcription factor, orchestrates the balance between fatty acid and flavonoid synthesis.
A recent study sheds light on Panax notoginseng, also known as Sanchi, by delving into its phytochemical profile and pharmacological potential. The research provides an in-depth review of the biosynthesis and regulation of ginsenosides, the herb's primary bioactive compounds known for their therapeutic effects.
Scientists have decoded the genetic blueprint of Atractylodes lancea, a prized herb in traditional Chinese medicine. Through comprehensive genome resequencing, the study unveils how natural variations drive the plant's evolution and metabolic adaptations, particularly affecting the production of key medicinal compounds.
Temple University’s Sbarro Institute for Cancer Research and Molecular Medicine has benefited from the support of Pennsylvania State Sen. Ryan Aument since he took office in 2014.
A recent study discovered that applying 5-Azacytidine, a DNA methylation inhibitor, significantly reduces tomato susceptibility to gray mold, a common postharvest fungal disease. This epigenetic strategy enhances the fruit's natural defense system, offering a sustainable and innovative method to boost crop resistance without genetic modification.
UNC School of Medicine researchers are the first to show that an microRNA molecule called miR-29 is instrumental in driving the natural aging process.
Demand for cancer genetic testing is on the rise, but there's not enough genetic counselors to guide patients through the process. Researchers say chatbots could be the answer.
Scientists have identified a crucial gene, CsMIKC1,that controls the number of flowering sites in Cannabis sativa, a finding that could significantly enhance both medicinal and grain yields. The study reveals how CsMIKC1 drives inflorescence development, offering new pathways to boost productivity in Cannabis cultivation.
Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, published in Cell, explain how chromosomes in some tumors undergo massive rearrangements and could lead to new strategies to avoid cancer drug resistance.
Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development.
Dr. Min-young Lee and Dr. Sung-gyu Park of the Advanced Bio and Healthcare Materials Research Division at KIMS have developed a technology that can detect cancer mutant genes in blood with the world's highest sensitivity of 0.000000001% based on plasmonic nanomaterials for optical signal amplification.
The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers from the Perelman School of Medicine at the University of Pennsylvania who co-led the clinical trial published in The Lancet.
About 8 to 10 million Americans over age 40 have an overabundance of cloned white blood cells, or lymphocytes, that hamper their immune systems. Although many who have this condition — called monoclonal B-cell lymphocytosis (MBL) — do not experience any symptoms, a new study shows they may have an elevated risk for several health complications, including melanoma, a form of skin cancer.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
The new approach marks a major step forward in the design of AI tools to support clinical decisions in cancer diagnosis, therapy. The model uses features of a tumor’s microenvironment to forecast how a patient might respond to therapy and to help inform individualized treatments.
A research team created seven learning models using Support Vector Machine (SVM) algorithms to discern flowering-time-associated genes (FTAGs) from non-FTAGs, with the SVM-Kmer-PC-PseAAC model performing the best (F1 score = 0.934, accuracy = 0.939, and receiver operating characterstic = 0.943).
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