Feature Channels: Immunology

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20-Jul-2023 10:30 AM EDT
CHOP Researchers Validate Pediatric “Allergic March” in Largest National Study of its Kind
Children's Hospital of Philadelphia

In the largest study of its kind, researchers from Children’s Hospital of Philadelphia (CHOP) used electronic health record (EHR) data from more than 200,000 pediatric patients to describe patterns of pediatric allergies across the United States, validating a population-level pattern of allergy development known as the “allergic march,” in which allergies first present as eczema, followed by food allergies, asthma, and environmental allergies. The researchers also found that a rare food allergy called eosinophilic esophagitis (EoE), which has historically been considered a disease affecting primarily White males, is more common among non-White patients than previously reported.

Released: 24-Jul-2023 5:30 PM EDT
Why we lose fat and muscle during infection
Salk Institute for Biological Studies

Although infections can present with many different symptoms, one common symptom is the loss of fat and muscle, a process called wasting.

Released: 24-Jul-2023 5:20 PM EDT
How the microbiome drives the evolution of immune defenses
École Polytechnique Fédérale de Lausanne (EPFL)

Animals and humans coexist with a vast array of microorganisms known as the microbiome, forming an intricate relationship that can range from mutually beneficial to pathogenic.

Not for public release

This news release is embargoed until 24-Jul-2023 5:00 PM EDT Released to reporters: 18-Jul-2023 2:00 PM EDT

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Released: 21-Jul-2023 2:05 PM EDT
Probiotic combo stops bacteria that cause toxic shock syndrome
American Society for Microbiology (ASM)

The widespread, pathogenic microbe Staphylococcus aureus can colonize the skin and mucous membranes throughout the body, particularly the vagina and gastrointestinal tract.

Released: 20-Jul-2023 4:25 PM EDT
Immune systems develop ‘silver bullet’ defences against common bacteria
University of Exeter

Immune systems develop specific genes to combat common bacteria such as those found in food, new research shows.

17-Jul-2023 7:05 PM EDT
Study sheds light on cellular interactions that lead to liver transplant survival
University of California, Los Angeles (UCLA), Health Sciences

A new study, which involved experiments on mice and human patients, uncovered an important communication pathway between two molecules called CEACAM1 (CC1) and TIM-3, finding that the pathway plays a crucial role in controlling the body's immune response during liver transplantation.

Released: 19-Jul-2023 4:20 PM EDT
New Innovation in CAR T-Cells Paves Way for Less Toxic Therapy Against Multiple Myeloma
University of Maryland School of Medicine

University of Maryland School of Medicine (UMSOM) researchers engineered a new type of CAR T-cell therapy that, in preclinical studies, selectively attacked cancer cells while sparing healthy cells, potentially reducing the likelihood of toxic side effects from this innovative cancer treatment.

17-Jul-2023 2:30 PM EDT
Treatment at the First Signs of MS Could Mean Lower Risk of Disability Later
American Academy of Neurology (AAN)

People who start taking medication soon after the first signs of multiple sclerosis (MS) may have a lower risk of disability later, according to a study published in the July 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 19-Jul-2023 1:05 PM EDT
Researchers Report Advance in Immune Therapy Against ALS
Federation of American Societies for Experimental Biology (FASEB)

New research suggests that targeting autoimmune inflammation associated with amyotrophic lateral sclerosis (ALS) using two drugs, one of them already approved for multiple sclerosis, could be a promising approach for treatment.

Released: 19-Jul-2023 1:00 PM EDT
Cancer Research Institute Awards Over $28 Million in Grants to Fuel Immunotherapy Innovations
Cancer Research Institute

The Cancer Research Institute awarded $28.7 million in research grants and fellowships in the 2023 fiscal year ending June 30, 2023. In total, CRI distributed 73 awards that will advance cancer immunology research at 41 institutions in 10 countries. CRI grants were awarded to support projects involving a variety of immune-based approaches as well as the development of novel technologies that may help pave the way for the next generation of immunotherapies.

Released: 19-Jul-2023 12:00 PM EDT
MD Anderson Research Highlights for July 19, 2023
University of Texas MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

   
Released: 19-Jul-2023 11:30 AM EDT
Tracing maternal behavior to brain immune function
Ohio State University

Immune system changes in the pregnant body that protect the fetus appear to extend to the brain, where a decrease in immune cells late in gestation may factor into the onset of maternal behavior, new research in rats suggests.

   
Newswise: Gene Mutation May Explain Why Some Don’t Get Sick from COVID-19
Released: 19-Jul-2023 11:25 AM EDT
Gene Mutation May Explain Why Some Don’t Get Sick from COVID-19
University of California, San Francisco (UCSF)

People who contract COVID-19 but never develop symptoms – the so-called super dodgers – may have a genetic ace up their sleeve. They’re more than twice as likely as those who become symptomatic to carry a specific gene variation that helps them obliterate the virus, according to a new study led by UC San Francisco researchers. 

Released: 19-Jul-2023 7:00 AM EDT
Flu during Pregnancy May Lead to Changes in Offspring’s Immune Function
American Physiological Society (APS)

A new study in mice suggests that having a common form of the flu during pregnancy may affect the next generation by impairing immune function in the gut. The study is published ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology.

Released: 18-Jul-2023 11:00 AM EDT
New MenB vaccine heralds use of genetic vaccines to combat bacterial diseases
University of Surrey

A vaccine candidate that can protect children from Meningococcal group B (MenB), which can lead to meningitis, has progressed to clinical development, according to an announcement by researchers from the University of Surrey and the University of Oxford.

Newswise: The double face of RNase as a treatment for systemic autoimmune diseases
Released: 18-Jul-2023 10:45 AM EDT
The double face of RNase as a treatment for systemic autoimmune diseases
Osaka University

Systemic autoimmune diseases are characterized by inflammation of multiple organs and can have devastating consequences for patients. There is a dire need for treatments against these diseases.

Newswise: Using AI to Speed Up Vaccine Development Against Disease X
Released: 18-Jul-2023 9:00 AM EDT
Using AI to Speed Up Vaccine Development Against Disease X
Houston Methodist

CEPI to provide up to $4.98 USD million to Houston Methodist Research Institute-led consortium to use artificial intelligence for design of vaccines to fight diseases with pandemic potential. The project will support a consortium, led by HMRI, to design potential antigenic targets for up to 10 priority virus families with epidemic or pandemic potential. Laboratory-based tests will then be used to verify antigen designs for possible further development.

Released: 18-Jul-2023 8:50 AM EDT
Rakuten Medical to Host Virtual R&D Day on Thursday, August 10, 2023
Rakuten Medical, Inc.

Rakuten Medical, Inc. (Rakuten Medical), a global biotechnology company developing and commercializing precision, cell-targeting photoimmunotherapy-based on its proprietary Alluminox™ platform, today announced it will host a virtual R&D Day on the preliminary safety and efficacy findings from its open-label Phase 1b/2 study of Alluminox™ treatment using ASP-1929 in combination with anti-PD-1 therapy in recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC).

Released: 17-Jul-2023 11:30 AM EDT
Discovery could lead to more treatments to prevent cancer and infectious diseases
Murdoch Childrens Research Institute

Researchers have cracked how a particular type of immune cell develops in the body and protects against infection and disease. And the discovery could help in the development of more preventive treatments, according to a new study.

Newswise: Pancreatic Cancer Vaccine Plus Immunotherapy and Antibody Spark Immune System Response in Pancreatic Cancers
Released: 17-Jul-2023 10:00 AM EDT
Pancreatic Cancer Vaccine Plus Immunotherapy and Antibody Spark Immune System Response in Pancreatic Cancers
Johns Hopkins Medicine

Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and urelemab, an anti-CD137 agonist antibody treatment, is safe, it increases the amount of cancer-killing immune system T cells in the tumors and it appears effective when given two weeks prior to cancer-removal surgery, according to new research directed by Johns Hopkins investigators.

Newswise:Video Embedded innovative-approach-to-chronic-sinusitis-unconventional-infections
VIDEO
Released: 14-Jul-2023 5:20 PM EDT
Atypical infections in chronic sinusitis: thinking outside the box
Impact Journals LLC

Inflammations of the paranasal sinuses represent a common clinical picture. The annual prevalence of chronic sinusitis in Europe is up to 10%.

Released: 13-Jul-2023 5:05 PM EDT
Delayed RSV Prophylactic During Atypical RSV Surges and RSV Hospitalization Spikes in High-Risk Kids
Ann and Robert H. Lurie Children's Hospital of Chicago

As a result of the COVID-19 pandemic, respiratory syncytial virus (RSV) surges in young children occurred outside the usual November to March season, when immune-based prophylactic is available to protect children at high risk for severe illness.

Newswise: TTUHSC El Paso Professor Receives Grant for Research on Potential Breast Cancer Treatment
Released: 13-Jul-2023 12:00 PM EDT
TTUHSC El Paso Professor Receives Grant for Research on Potential Breast Cancer Treatment
Texas Tech University Health Sciences Center El Paso

Breast cancer is the second leading cause of cancer mortality in women and the primary cause of cancer death among Hispanic women, according to the National Cancer Institute. The Center of Emphasis in Cancer focuses on forms of the disease prevalent in our majority-Hispanic Borderplex, seeking new strategies for the prevention and treatment of the deadly disease.

Newswise: Development of new p38 protein inhibitors with therapeutic potential for some heart diseases
Released: 13-Jul-2023 8:15 AM EDT
Development of new p38 protein inhibitors with therapeutic potential for some heart diseases
Institute for Research in Biomedicine Barcelona

A multidisciplinary team led by Dr. Ángel R. Nebreda, Dr. María J. Macías and Dr. Modesto Orozco, all at IRB Barcelona, has developed a new type of p38 inhibitor, which preferentially impairs one of the activation pathways of this protein. In particular, these inhibitors block the self-activation (or autophosphorylation) of p38 but allow it to continue to be activated by other mechanisms.

Released: 12-Jul-2023 6:30 PM EDT
Researchers report advance in immune therapy against ALS
University of California, Los Angeles (UCLA), Health Sciences

New research suggests that targeting autoimmune inflammation associated with amyotrophic lateral sclerosis (ALS) using two drugs, one of them already approved for multiple sclerosis, could be a promising approach for treatment.

Released: 12-Jul-2023 6:00 PM EDT
How the immune system can alter our behavior
Yale University

Scientists have long known that the immune system played a key role in our reactions to allergens and pathogens in the environment, but it was unclear whether it played any role in prompting these types of behaviors towards allergic triggers. According to Yale-led research published July 12 in the journal Nature, it turns out that the immune system plays a crucial role in changing our behaviors.

Newswise: Notre Dame researchers invent trap for capturing and comparing individual bacterial cells
Released: 12-Jul-2023 3:25 PM EDT
Notre Dame researchers invent trap for capturing and comparing individual bacterial cells
University of Notre Dame

Together, Notre Dame's Paul Bohn and Joshua Shrout are searching for new ways to observe microorganisms like P. aeruginosa, moving beyond the traditional process of observing cell cultures grown in a Petri dish.

   
7-Jul-2023 8:00 AM EDT
A new tactic to take on leprosy
American Chemical Society (ACS)

Though antibiotics can treat leprosy, researchers are concerned about the increase in drug-resistant strains. Now, a team reporting in ACS Central Science has begun to understand the role certain immune receptors play in leprosy, which could lead to new types of treatments for this disease.

   
Newswise: Changing the way we deliver immune-based cancer drugs could reduce costs by 14%
Released: 11-Jul-2023 11:45 AM EDT
Changing the way we deliver immune-based cancer drugs could reduce costs by 14%
Michigan Medicine - University of Michigan

A new analysis finds that up to millions of dollars could be saved annually on cancer immunotherapy treatments across the Veterans Health Administration by reconsidering how those drugs are delivered.

Newswise: Gene that regulates immune activity in the retina identified
Released: 11-Jul-2023 11:25 AM EDT
Gene that regulates immune activity in the retina identified
UT Southwestern Medical Center

UT Southwestern Medical Center researchers have identified a gene called Lipe that appears to be pivotal to retinal health, with mutations spurring immune activation and retinal degeneration. This is important because the retina is responsible for detecting the light that is transformed into vision. The findings, published in Communications Biology, provide clues about the mechanisms behind a variety of disorders affecting the retina, including macular degeneration and diabetic retinopathy.

Newswise: 3D bioprinting technology to be used for removing cancer cells
Released: 11-Jul-2023 12:00 AM EDT
3D bioprinting technology to be used for removing cancer cells
National Research Council of Science and Technology

Through joint research with the Korea Institute of Machinery and Materials(KIMM), the Korea Research Institute of Bioscience and Biotechnology (KRIBB) developed a 3D bioprinting technology using natural killer cells (NK cells) as a new method of immunotherapy for treating cancer.

   
Newswise: Tumor Monocyte Content Predicts Immunochemotherapy Outcomes for Esophageal Cancer
Released: 10-Jul-2023 11:15 AM EDT
Tumor Monocyte Content Predicts Immunochemotherapy Outcomes for Esophageal Cancer
Ludwig Cancer Research

A Ludwig Cancer Research study has discovered that the presence of relatively high numbers of immune cells known as monocytes in tumors is linked to better outcomes in esophageal cancer patients treated with a combination of chemotherapy and immunotherapy, or immunochemotherapy.

Newswise: UTSW researchers report progress in malaria treatments
Released: 10-Jul-2023 10:45 AM EDT
UTSW researchers report progress in malaria treatments
UT Southwestern Medical Center

With new cases of malaria being reported in Texas and Florida, researchers at UT Southwestern Medical Center continue to explore compounds for more effective drug-resistant therapies and biological targets to interfere with the parasites that spread the potentially fatal disease.

Released: 7-Jul-2023 4:40 PM EDT
Tip Sheet: Understanding cancer-related pain, newborn screening for deadly immune disorder — and new Fred Hutch leadership
Fred Hutchinson Cancer Center

Below are summaries of recent Fred Hutchinson Cancer Center research findings and other news. If you’re looking for resources who can comment on skin cancer awareness and skin protection during the summer months, see our list of experts and reach out to [email protected] to set up interviews.

Newswise: Researchers find weaker immune response to viral infections in children with mitochondrial disorders
Released: 7-Jul-2023 2:40 PM EDT
Researchers find weaker immune response to viral infections in children with mitochondrial disorders
NIH, National Human Genome Research Institute (NHGRI)

In a new study, National Institutes of Health (NIH) researchers found that altered B cell function in children with mitochondrial disorders led to a weaker and less diverse antibody response to viral infections.

Newswise: Chulalongkorn University Pharmaceutical Researchers Win Gold and Two Special Awards at INTARG 2023 in the Republic of Poland
Released: 7-Jul-2023 8:55 AM EDT
Chulalongkorn University Pharmaceutical Researchers Win Gold and Two Special Awards at INTARG 2023 in the Republic of Poland
Chulalongkorn University

Prof. Pol.Capt. Pharm. Dr. Suchada Sukrong, lecturer at the Faculty of Pharmaceutical Sciences and a researcher at the Center of Excellence in DNA Barcoding of Thai Medicinal Plants, Chulalongkorn University, Dr. Kannika Thongkhao, and Pharm. Chayaphol Tangpatthong have won the gold medal and two Special Awards, namely the FIRI Award in the Best Invention category from “The first institute of inventors and researchers of Iran” (FIRI), Iran, and a Special Awards from “The Industrial Property Office of the Czech Republic the Czech Metallurgical Society,” The Czech Republic, in The 16th International Invention and Innovation Show (INTARG 2023) on May 24-25, 2023, at Katowice International Conference Center, Katowice, Republic of Poland, with their “Rapid DNA immunochromatographic assay for detection of toxic Aristolochia species, the plants responsible for aristolochic acid nephropathy”.

Newswise: Preclinical Studies Led by Johns Hopkins Medicine Researchers Advance Potential New Target to Treat HIV Infection
Released: 6-Jul-2023 12:05 PM EDT
Preclinical Studies Led by Johns Hopkins Medicine Researchers Advance Potential New Target to Treat HIV Infection
Johns Hopkins Medicine

Researchers at Johns Hopkins Medicine, in collaboration with researchers at the National Institutes of Health, report that two new studies in mice with a humanized immune system and human cell lines have identified an enzyme that plays a critical role in the late stages of HIV replication.

Newswise: Study finds new potential therapy option for patients with chronic lymphocytic leukemia
Released: 6-Jul-2023 11:25 AM EDT
Study finds new potential therapy option for patients with chronic lymphocytic leukemia
Ohio State University Wexner Medical Center

Researchers continue to refine and improve targeted drug therapies that have changed the most common form of adult leukemia – from an incurable to a chronic condition. New data published in the New England Journal of Medicine offers another treatment option for patients who have stopped responding to the first and second generation drugs.

Released: 5-Jul-2023 4:40 PM EDT
Immune deficiency following severe spinal cord injury
Charité - Universitätsmedizin Berlin

Nerve pathways in the spinal cord can be damaged or severed after an accident or serious injury, a condition known as paraplegia. Depending on where the injury is located, different parts of the body may be affected by deficits or paralysis.

Newswise: First New Jersey Patient Treated with Genetically Modified T-Cells Developed at state’s only National Cancer Institute-designated Comprehensive Cancer Center
Released: 5-Jul-2023 12:45 PM EDT
First New Jersey Patient Treated with Genetically Modified T-Cells Developed at state’s only National Cancer Institute-designated Comprehensive Cancer Center
Rutgers Cancer Institute

Rutgers Cancer Institute of New Jersey has treated its first patient using genetically modified T-cells that were manufactured in its own state-of-the-art Good Manufacturing Practices (GMP) facility.

Newswise: Immune and tumor cell “tug-of-war” controls anti-cancer activity
Released: 5-Jul-2023 11:55 AM EDT
Immune and tumor cell “tug-of-war” controls anti-cancer activity
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital found that altering amounts of the nutrient glutamine in the tumor microenvironment could enhance or impair the immune system’s anti-cancer response.

3-Jul-2023 10:25 AM EDT
Long Covid not caused by COVID-19 immune inflammatory response, new research finds
University of Bristol

Long Covid, which affects nearly two-million people in the UK (1), is not caused by an immune inflammatory reaction to COVID-19, University of Bristol-led research finds. Emerging data demonstrates that immune activation may persist for months after COVID-19.

Released: 3-Jul-2023 3:05 PM EDT
Supportive communities can help increase breastfeeding rates for moms
University of Missouri, Columbia

While formula-feeding babies is a safe and convenient option, research studies have shown natural breastfeeding is linked to numerous health benefits for both mother and child.

Newswise: June Research Highlights
Released: 30-Jun-2023 2:45 PM EDT
June Research Highlights
Cedars-Sinai

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for June 2023.

Released: 28-Jun-2023 3:05 PM EDT
Icahn School of Medicine at Mount Sinai Researchers Awarded $15.1 Million Grant to Explore Immune Rejection of Transplanted Organs
Mount Sinai Health System

Striving to improve organ transplant survival rates, internationally renowned researchers in immunology and bioengineering at the Icahn School of Medicine at Mount Sinai have received $15.1 million from the National Institute of Allergy and Infectious Diseases (NIAID) to lead a novel, five-year multi-center research program that will explore trained immunity—the innate immune system’s ability to remember infections and other insults—as a target for preventing organ transplant rejection.



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