A combination of a novel inhibitor of the protein CK2 (Casein kinase 2) and an immune checkpoint inhibitor has dramatically greater antitumor activity than either inhibitor alone, according to research from The Wistar Institute that was published online in Cancer Research.
Psychopaths, the monsters in the closet of so many of our favorite television shows and podcasts, are far more complex than we might have initially imagined.
Three Penn Medicine ophthalmology innovators received the 2018 António Champalimaud Vision Award for their revolutionary work leading to the first successful gene therapy to cure an inherited cause of childhood blindness.
Wistar scientists have applied their synthetic DNA technology to engineer a novel eCD4-Ig anti-HIV agent and to enhance its potency in vivo, providing a new simple strategy for constructing complex therapeutics for infectious agents as well as for diverse implications in therapeutic delivery.
A practice known for providing high-level oncology and hematology services to people in central Pennsylvania for more than 30 years is now part of Penn State Health Medical Group.
In an upcoming project, a team of Penn State researchers will use mice as a model for creating high-resolution, 3D maps of the blood vessels in both young and aging brains.
Sitting for too many hours per day, or sitting for long periods without a break, is now known to increase a wide range of health risks, even if one engages in recommended amounts of physical activity. The health risks of prolonged sedentary time – and nurses' role in reducing those risks – are discussed in an integrative literature review and update in the September issue of the American Journal of Nursing. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Patient satisfaction after plastic surgery is most affected by surgeon-related factors, such as taking the time to answer questions and including patients in the decision-making process, reports a study in the September issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Providing "targeted" social support to other people in need activates regions of the brain involved in parental care – which may help researchers understand the positive health effects of social ties, reports a study in Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society. The journal is published in the Lippincott Portfolio by Wolters Kluwer.
Teens are more prone to addiction because it’s a form of learning. Just as it’s easier for a younger brain to pick up new languages, athletic techniques, or musical instruments, it’s easier for them to pick up addictions.
High fever. Cough. Runny nose. Red, watery eyes. It may not be the flu. It could be measles.
The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists from the Perelman School of Medicine at the University of Pennsylvania is the first to examine how common this stigma may be among the general population of the United States as well as among medical students.
Independence in mobility is the single most important factor affecting quality of life in patients with traumatic spinal cord injury (TSCI), reports a study in the American Journal of Physical Medicine & Rehabilitation, the official journal of the Association of Academic Physiatrists. The journal is published by Wolters Kluwer.
The Monell Center and Jefferson (Philadelphia University and Thomas Jefferson University) announce the signing of a one-year Agreement of Cooperation, outlining how the two institutions will collaborate over the next year to develop joint scientific programs and clinical opportunities to advance their shared mission of improving human health.
Wolters Kluwer Health announced today it will begin electronic publishing of Evidence-Based Practice, the official journal of the Family Physicians Inquiries Network (FPIN). The monthly journal, which focuses on topics relevant to the daily practice of family medicine, will be curated in the Lippincott portfolio beginning in September 2018.
Pediatric researchers have identified a gene mutation that causes a serious lymphatic condition, and used that knowledge to restore normal lymphatic vessels in model animals. The laboratory findings may lead to a new therapy for patients with this type of abnormal lymphatic circulation. Abnormal lymphatic flow may cause respiratory distress and other serious symptoms.
With medical school loan debt averaging $200,000, many physicians pursue the Public Service Loan Forgiveness Program that eliminates federal student loans after 10 years of service in the public sector. But the fate of the program hangs in the balance, as government officials signal a desire to end it, leaving physicians in a lingering uncertainty that’s unnecessary and unfair, health policy experts from the Perelman School of Medicine at the University of Pennsylvania and three other medical institutions argue in a new commentary published in the Annals of Internal Medicine.
Charles B. Berde, MD, PhD, of Boston Children’s Hospital and Harvard Medical School has been selected to receive ASRA’s 2018 John Bonica Award.
Oncologists from Children’s Hospital of Philadelphia today celebrated a watershed moment in medicine: approval by the European Commission of Kymriah (tisagenlecleucel, formerly CTL019) --the first-ever FDA-approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers, pioneered together with Novartis and the Perelman School of Medicine at the University of Pennsylvania.
Adding another inhibitor to therapies that cut off a tumor’s access to blood vessels could be the key to helping those therapies overcome resistance in glioblastoma, a deadly form of brain cancer.
The European Commission (EC) has approved a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, making it the first chimeric antigen receptor (CAR) T cell therapy permitted for use in the European Union in two distinct indications.
A team of researchers from Penn State’s Materials Research Institute and the University of Utah has developed a wearable energy harvesting device that could generate energy from the swing of an arm while walking or jogging. The device, about the size of a wristwatch, produces enough power to run a personal health monitoring system.
Like other data-driven organizations, healthcare networks are vulnerable to potentially crippling cyberattacks – but may lag behind other sectors in preparing for and avoiding data breaches, according to a series of articles and commentaries in the Fall issue of Frontiers of Health Services Management, an official publication of the American College of Healthcare Executives (ACHE). This journal is published in the Lippincott portfolio by Wolters Kluwer.
Inhibition of miR-24-3p reduced growth of cancer cells and was found to regulate proteins as a potential treatment target for Mesothelioma (MPM). The new potential target, and the method researchers have used to identify it, is an important step in addressing this challenging disease.
A self-healing membrane that also acts as a reverse filter can block small particles and let large ones through is possible, according to Penn State mechanical engineers who say it is "straight out of science fiction."
Do you wish you could decrease your waistline? Reducing abdominal obesity can lower health risks – but despite claims you may have seen on the Internet, no trending diet can help you specifically eliminate belly fat, according to an article in ACSM's Health & Fitness Journal®, an official journal of the American College of Sports Medicine (ACSM). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Californians do not purchase electric vehicles because they are cool, they buy EVs because they live in a warm climate. Conventional lithium-ion batteries cannot be rapidly charged at temperatures below 50 degrees Fahrenheit
Cynthia Connolly’s, PhD, RN, FAAN, book, Children and Drug Safety: Balancing Risk and Protection in Twentieth Century America, just received the distinguished Arthur J. Viseltear Prize. This award is given each year by the American Public Health Association (APHA) to a historian who has made outstanding contributions to the history of public health, either through a body of scholarship or through a recent book (published within the previous two years).
Although black and Hispanic veterans with chronic kidney disease (CKD) are more likely than white patients to see a kidney specialist—a nephrologist—they are more likely to suffer disease progression from early stage to advanced kidney disease, reports a study published this month in the Journal of the American Society of Nephrology from researchers at the Perelman School of Medicine at the University of Pennsylvania.
Although some people are genetically more susceptible to the stressors of daily life than others, most could benefit from learning how to lower that stress before it negatively affects their physical and mental health.
Penn’s Radiation Oncology department has recently added a VR mindfulness experience to its waiting room in the Roberts Proton Therapy Center.
Nicole O’Donnell says her first love was benzodiazepines. Now, 2 overdoses and nearly a decade of sobriety later, the mother of two is working towards a bachelor's degree in Psychology and is using her personal journey to make a difference in the lives of those struggling with addiction.
Researchers who tested two commercially available baby monitors are raising serious concerns about the accuracy of these products, which are marketed to parents, but are not regulated by the U.S. Food & Drug Administration.
The genome sequences of ape parasites related to Plasmodium vivax, the main source of mosquito-borne malaria outside Africa, provide insights on the origin and early evolution of the human parasite. This finding could have implications for better comprehending and eradicating malaria infection worldwide.
A team of researchers from Penn Medicine has developed the first mouse model with an IPF-associated mutation, which induces scarring and other damage similar to what is observed in humans suffering from the condition.
Assistant Professor of Physics Tristan Smith has received a NASA grant to support his work in developing new ways to identify and measure the physics of the dark universe.
An athlete is sailing through the air or making a quick turn when all of a sudden he or she hears a “pop” in the knee. An athlete who experiences this followed by sudden pain and swelling often receives the much-feared diagnosis of an anterior cruciate ligament (ACL) tear.
Carl June, MD, a gene therapy pioneer at the Abramson Cancer Center of the University of Pennsylvania, will receive the 2018 Albany Medical Center Prize in Medicine and Biomedical Research.
Summer is the season of barbeque, beach trips, and some of the simplest joys of life, but if you’re not careful, it can also be the lone enemy of one of the most important joys of them all: sleep.
Over the past decade, salaries for hospital CEOs have risen much faster than for surgeons, physicians, and nurses, reports a study in Clinical Orthopaedics and Related Research® (CORR®), a publication of The Association of Bone and Joint Surgeons®. The journal is published by Wolters Kluwer.
Study from the American Cancer Society, published in JNCCN--Journal of the National Comprehensive Cancer Network, found cancer patients who were more satisfied with the communication they received, had better health results at lower costs
The diabetes epidemic in Guatemala is worse than previously thought: more than 25 percent of its indigenous people, who make up 60 percent of the population, suffer from type 2 diabetes or pre-diabetes, suggests a new study published in PLOS One from researchers at the Penn Center for Global Health.
It’s a longstanding mystery why salamanders can perfectly regenerate their tails whereas lizard tails grow back all wrong. By transplanting neural stem cells between species, Pitt researchers have discovered that the lizard’s native stem cells are the primary factor hampering tail regeneration.
Medicare patients nationwide have low rates of preventive care visits – with the lowest rates found in older adults of minority race/ethnicity, reports a study in the September issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.
The members of the Association of American Cancer Institutes (AACI) have elected Karen E. Knudsen, PhD, as vice president/president-elect of AACI’s board of directors. In addition to Dr. Knudsen, four leaders of AACI member cancer centers will join the board at the AACI/CCAF Annual Meeting on September 30.
ASRA's fourth exam candidates have been certified.
As marine mammals evolved to make water their primary habitat, they lost the ability to make a protein that defends humans and other land-dwelling mammals from the neurotoxic effects of a popular man-made pesticide.
Blocking nuclear gateways that traffic cancer-promoting molecules to nucleus, could offer a new way to target aggressive cancer.
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