Focus: Hidden - Philly Metro

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Penn Medicine experts in nephrology and health policy call for more transparency about joint-venture ownership of dialysis clinics to better understand what impact these arrangements may have on patient referrals and clinical outcomes. The lack of transparency poses a major barrier for evidence-based health care policy research and deprives patients of critical information, the researchers write in a new Perspective published in the New England Journal of Medicine.

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Congenital muscular torticollis (CMT) is a common postural deformity in infants, and one that can be effectively treated by physical therapy. A set of updated, evidence-based recommendations for physical therapy management of CMT is presented in the October issue of Pediatric Physical Therapy. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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The medical conference is organized by the Sbarro Health Research Organization (SHRO), in collaboration with Temple University’s College of Science and Technology, the National Italian American Foundation (NIAF), and the Giovan Giacomo Giordano Foundation

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A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer.

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The National Institutes of Health grant supports a collaboration between Temple University's dentistry and psychology researchers

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Wolters Kluwer, Health announced today that Novant Health is utilizing the Lippincott® Solutions suite to advance its wide-ranging quality improvement initiatives focused on standardizing care across 15 acute care hospitals and medical centers in four U.S. states. By equipping nurses with readily available evidence-based decision support and clinical education resources, Lippincott Solutions plays an important role in helping Novant Health facilities maintain Magnet Recognition®.

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Penn Medicine's new Molecular Integration in Neurological Diagnosis Initiative brings the power of precision medicine to Parkinson’s disease research.

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Foundation Awards Presented for Ethics and Creativity in Medical Research, and Societal Impact in Business & Biotechnology

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Placement of nasogastric (NG) tubes (feeding tubes) in pediatric patients is a common practice, however, the insertion procedure carries risk of serious or even potentially lethal complications. While there are numerous methods of verifying an NG tube has been placed correctly, none of those methods are considered universally standard.

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A special November issue of Health Physics journal presents 13 original research papers, reviews, and commentaries related to women’s contributions to and experiences in radiation protection and safety. Health Physics, the official journal of the Health Physics Society (HPS) is published in the Lippincott portfolio by Wolters Kluwer.

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An Ivy League experimental rule that moved the kickoff line from the 35- to the 40-yard line and the touchback line from the 25- to the 20-yard line reduced the average annual concussion rate by more than 68 percent, according to the research conducted by a team from The Ivy League and Perelman School of Medicine at the University of Pennsylvania.

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Maybe the genetic test report your doctor ordered says your DNA contains many “variants of unknown significance.” But suppose at a later date a researcher discovers one of those changes causes a disease? How will you learn this new piece of information? You can’t even be sure your doctor will find out about it.

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By investigating how genetic variations drive the expression of genes within the filtering cells of the kidney, researchers have found new pathways to explain CKD development and could inform its treatment.

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In a study examining the potential impact of 2001-02 Medicaid expansions by Arizona, Maine and New York – expansions that occurred just prior to the rise in overdose mortality nationwide – researchers from the Perelman School of Medicine at the University of Pennsylvania found that from the time of these expansions through 2008, overdose mortality rates (mostly driven by fatal overdoses of opioids) rose significantly less in the expansion states than in non-expansion states.

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Wistar scientists have implemented a novel structurally designed synthetic DNA vaccine to simultaneously target multiple members of a family of proteins that are specifically overexpressed in several types of cancer.

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Persistent and significant health disparities related to sexual health, including a higher teen birth rate and HIV prevalence, exist among Puerto Rican adolescents compared to other racial and ethnic adolescents. The Internet is a major platform for the dissemination of health information and has the potential to decrease health disparities and provide quality, culturally sensitive health information to disadvantaged populations.

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In low-resource countries without well-developed screening programs, expanding access to human papilloma virus (HPV) vaccination is the best means of preventing cervical cancer and other diseases caused by HPV infection, according to an editorial in the October special issue of the Journal of Lower Genital Tract Disease, official journal of ASCCP. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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National Comprehensive Cancer Network (NCCN) moves into new global headquarters in Plymouth Meeting, PA, in the Greater Philadelphia area, less than three hour's drive from Washington, D.C., New York City, and Princeton, NJ.

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Severe weather events, such as summer hurricanes, tornadoes, and winter snow storms often result in widespread and prolonged power outages, interrupting essential household functions, including home heating. In such a scenario, people may use generators and risk carbon monoxide poisoning.

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A new Philadelphia-based start-up, Virion Therapeutics, LLC spun out of The Wistar Institute, will work to advance innovative, immune-based therapies for the treatment of chronic viral-associated cancers and viral infections utilizing the first genetically encoded checkpoint inhibitor that can be given via vaccination.

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A compound secreted in the bloodstream could be the key factor that causes wounds in older people to heal with less scarring than in younger people.

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Kathryn H. Bowles, PhD, RN, FAAN, FACMI, the van Ameringen Chair in Nursing Excellence and a Professor in Penn Nursing’s Department of Biobehavioral Health Sciences, will receive the 15th annual Claire M. Fagin Distinguished Researcher Award. The biennial award honors the best scholarly qualities that Dr. Fagin, the School’s third Dean, exemplified.

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A comparison of two of the most common combination therapies for locally advanced prostate cancer show the more aggressive option is linked with a higher rate of survival.

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Research from the Monell Center extends the scope and significance of personal odors as a source of information about an individual’s health. A new paper reveals that the bodily odors of otherwise healthy animals sharing an environment with sick animals become like the odors of the sick animals.

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In the largest multi-institutional study to date, led by researchers from Penn Medicine, the team found that among patients who underwent a transcatheter aortic valve replacement, a high number experienced severe and moderate cases of prosthesis-patient mismatch. The team also found that the risk of death and of heart failure readmissions were higher.

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Infants born prematurely face challenges in developing the complex, interrelated skills needed for effective feeding. An assessment called the Early Feeding Skills (EFS) checklist is a valid and reliable tool for evaluating the emergence of feeding skills in preterm infants, reports a study in Advances in Neonatal Care, official journal of the National Association of Neonatal Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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A therapeutic vaccine can boost antibodies and T cells, helping them infiltrate tumors and fight off human papillomavirus (HPV)-related head and neck cancer. Researchers from the Abramson Cancer Center of the University of Pennsylvania tested the immunotherapy approach in two groups of patients with advanced head and neck squamous cell carcinoma (HNSCCa) and found 86 percent showed elevated T cell activity.

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Hurricane Florence made landfall in North and South Carolina days ago, but Penn Medicine Hospitals and other facilities nationwide have planned for weeks to adapt to expected drug shortages associated with its path of destruction.

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– Implementing an electronic medical records (EMR) system at an orthopaedic clinic may have unanticipated effects on clinic efficiency and productivity – including a temporary increase in labor costs and a lasting reduction in time spent interacting with patients, reports a study in September 19, 2018 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

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Gifts made to Temple University in the fiscal year that ended June 30 totaled nearly $98 million, surpassing the previous year’s record by more than $7 million.

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Effective management of neonatal abstinence syndrome (NAS) – withdrawal symptoms occurring in infants exposed to opioids in utero – requires a coordinated "cascade of care" from prevention through long-term follow-up, reports a study in Advances in Neonatal Care, official journal of the National Association of Neonatal Nurses. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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Higher education deeply values online learning, but a lung transplant coordinator is now teaching a virtual class that allows the personal caregivers of patients to learn all about their role - and make the patient eligible for the wait list.

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A new $18 million grant to Penn Medicine researchers will allow them to take aim at the effects of tobacco marketing. The U.S. Food and Drug Administration (FDA) and National Institutes of Health (NIH) have renewed their commitment to the Tobacco Centers of Regulatory Science (TCORS) program and awarded a second cohort (TCORS 2.0) of centers.

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Separated entry and exit doors for calcium keep energy production smooth in the powerhouses of heart cells.

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New research from the Monell Center suggests that a little-understood sensory cell may protect the vulnerable olfactory epithelium by detecting and initiating defenses against viruses, bacteria, and other potentially harmful invaders.

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he University of Pennsylvania Health System and Grand View Health have announced a new alliance focused on the development of joint clinical care programs to improve health care for people in Bucks and Montgomery counties and the surrounding areas.

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Women receiving silicone breast implants may be at increased risk of several rare adverse outcomes compared to the general population, reports a study in Annals of Surgery. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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Temple University collaborates with 56 other colleges and universities to offer scholarships

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Researchers from Netherlands Cancer Institute recommend qualitative and quantitative measurements that can lead to more successfully coordinated cancer care, finds need for better organization around the integration of care, according to article in September 2018 issue of JNCCN-Journal of the Comprehensive Cancer Network.

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Children who experience some type of adverse event following initial immunization have a low rate of recurrent reactions to subsequent vaccinations, reports a study in The Pediatric Infectious Disease Journal, the official journal of The European Society for Paediatric Infectious Diseases. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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The "patient-centered medical home" (PCMH) approach is an important tool for providing coordinated care for the millions of American children with special healthcare needs. But most of these special-needs children don't have access to care consistent with the PCMH approach, reports a study in the October issue of Medical Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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– Primary care clinics experienced a significant decline in influenza vaccinations as the day progressed, researchers from Penn Medicine report in a new study published in JAMA Open Network. However, “nudging” clinical staff to order vaccines using a behavioral economics technique known as “active choice” may help curb some of that drop off, the study suggests. The study is the first to show how clinic appointment times can influence influenza vaccination rates.

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Jules Lipoff, MD, an assistant professor of Clinical Dermatology at Penn, talks about what makes medicine so compelling for TV drama.

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A new collaboration grant to Discovery BioMed and the Monell Center will support development of next-generation screening technologies to identify bitter taste blockers. The work will advance health by improving the taste and acceptability of nutritious plant-based foods and increasing patient willingness to take life-saving oral medicines.

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National Comprehensive Cancer Network convenes Policy Summit to address changing care paradigms, and the impact across the cancer care continuum

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Older adults can help boost their memory and stay independent longer, with a little help and motivation.

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A major US children's hospital introduced a first-of-its-kind project to eliminate or reduce pain from elective needle procedures in all infants and children, reports a study in PAIN Reports®, part of a special issue on research innovations in pediatric pain. The official open-access journal of the International Association for the Study of Pain (IASP), PAIN Reports is published in the Lippincott portfolio by Wolters Kluwer.

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NCCN Oncology Research Program puts out request for proposals (RFP) for innovative strategies to improve patient outcomes for people with gastric and gastroesophageal junction cancer. Letters of intent due October 24.

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Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation. When combined with a nuclear DNA mutation in mice, one mitochondrial variant made heart disease worse, while another variant conferred protection.

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National Comprehensive Cancer Network publishes NCCN Guidelines for Patients: Uterine Cancer during Gynecologic Cancer Awareness Month to explain treatment options and raises awareness of endometrial cancer, the most common type of gynecologic cancer.