More than one-eighth of the randomized trials of cancer drugs seeking regulatory approval in China in recent years used inappropriate controls to test the effectiveness and safety of the drugs, according to a new study published December 12th in the open access journal PLOS Medicine by Professor Xiaodong Guan of Peking University, China, and colleagues.
Lower levels of vitamin D found in inflammatory bowel disease (IBD) patients are linked to inflammation, potentially playing a role in the disease's development, findings from a cross-sectional observational study published in Medicine® show.
The targeted therapy combination of ibrutinib and venetoclax significantly improved progression-free survival (PFS) and achieved an overall remission rate in 82% of patients with relapsed/refractory mantle cell lymphoma (MCL), according to researchers at The University of Texas MD Anderson Cancer Center. Results from the Phase III SYMPATICO trial were presented at the 2023 American Society of Hematology (ASH) Annual Meeting.
Most patients with Type 2 diabetes will end up needing to add a second-line medication after metformin — the go-to primary drug for glucose management — to control their blood sugar levels. But adherence to these second-line drugs can be hit or miss, reports a new Northwestern Medicine study.
Tuberculosis (TB) is a prevalent infectious disease that affects millions of people each year. It was previously the leading cause of death from a single pathogen before the COVID-19 pandemic. Detecting TB early is challenging because the bacterium Mycobacterium tuberculosis (Mtb) can hide in human macrophages, which are part of the immune system
Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a potential Alzheimer’s disease (AD) therapy.
Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development.
Data from Australian researchers could partly explain why a trial of a new drug for diabetes, was recently halted because it was found to be so effective. Importantly, the data also reveals how anti-obesity drugs like Ozempic, actually work, which to date have been a mystery.
MD Anderson and Rigel Pharmaceuticals announced a multi-year strategic development collaboration to expand the evaluation of olutasidenib in acute myeloid leukemia and other hematologic cancers.
Researchers at Case Western Reserve University and University Hospitals have identified an enzyme that blocks insulin produced in the body—a discovery that could provide a new target to treat diabetes.
Researchers at St Vincent’s Institute of Medical Research (SVI) in Melbourne have shown that a commonly prescribed rheumatoid arthritis drug can suppress the progression of type 1 diabetes. The world-first human trial, published today in the New England Journal of Medicine and led by SVI’s Professor Thomas Kay, showed that a drug called baricitinib can safely and effectively preserve the body’s own insulin production and suppress the progression of type 1 diabetes in people who initiated treatment within 100 days of diagnosis.
New research could one day pave the way for the treatment of vaginal yeast infections, by shedding new light on how microbes in the body absorb zinc.
Like any typical car or house or society, the pace at which parts of our bodies fall apart varies from part to part.
New research published in Arthritis & Rheumatology suggests that for people overweight or with obesity who also have knee or hip osteoarthritis, a slow-to-moderate—but not fast—rate of weight loss caused by anti-obesity medications may lower their risk of premature death.
.jpg&width=400&height=400)
Researchers from McMaster University have found that cholinesterase inhibitors, a type of common medication used to treat dementia, are not associated with an increased risk of falling. However, they found that the medication increased the risk of syncope, or fainting.
A new UCLA Health study is shedding light on how using hormonal contraceptive pills may affect women’s responses to stress and their risk for inflammation-related illnesses.
Researchers from at University of California San Diego, West Health, and the University of Washington have found evidence that the private insurers that sponsor Medicare Part D are artificially inflating the costs of certain generic drugs by overpaying pharmacies.
Value in Health announced the publication of 2 new commentaries by leading HEOR experts, both of which raise important questions as the Centers for Medicare & Medicaid Services move forward to implement the Inflation Reduction Act’s Medicare Drug Price Negotiation Program.
In a recent study, scientists led by Professor Stefan Müller from Goethe University’s Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML. The disease mainly occurs in adulthood and often ends up being fatal for older patients.
In a world where plant-based lifestyles are on the rise, the power of foods such as broccoli, celery, and tofu, which are rich in flavonoids, is becoming clearer. Flavonoids are phenolic compounds produced by plants that are essential for plant development and defense and have long been said to have therapeutic and preventive effects against cancer and heart disease.
Self-folding polymers containing gadolinium forming nanosized complexes could be the key to enhanced magnetic resonance imaging and next-generation drug delivery, as demonstrated by scientists at Tokyo Tech. Thanks to their small size, low toxicity, and good tumor accumulation and penetration, these complexes represent a leap forward in contrast agents for cancer diagnosis, as well as neutron capture radiotherapy.
Dr. Kathryn Lemberg in her lab. Credit: Norm Barker Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.
The American Society for Pharmacology and Experimental Therapeutics President Namandjé Bumpus will take over as the U.S. Food and Drug Administration’s (FDA) Principal Deputy Commissioner early next year.
In today's medical landscape, antibiotics are pivotal in combatting bacterial infections. These potent compounds, produced by bacteria and fungi, act as natural defenses against microbial attacks.
Scientists have created tiny moving biological robots from human tracheal cells that can encourage the growth of neurons across artificial ‘wounds’ in the lab. Using patients’ own cells could permit growth of Anthrobots that assist healing and regeneration in the future with no need for immune suppression. Lead researchers Prof Michael Levin and Gizem Gumuskaya from Tufts University will provide a brief commentary on the science and potential impact of this discovery, followed by Q&A with reporters.
Presage Biosciences, a pioneering translational oncology company whose mission is to use CIVO and spatial molecular profiling to understand the complexity of drug response in the tumor microenvironment (TME), has entered into an agreement with AstraZeneca (LSE/STO/Nasdaq: AZN), a global biopharmaceutical company.
A nearly decade-long study by UCLA researchers found that substance abuse treatment of any kind may help to reduce methamphetamine usage among men who have sex with other men.
For many people with migraine, it can be difficult to find a treatment that is effective and reliable, and information on how medications compare to one another is lacking. A new study draws data from nearly 300,000 people using a smartphone app to help people make decisions about their medications. The study found that certain migraine medications like triptans, ergots and anti-emetics may be two to five times more effective than ibuprofen for treating migraine attacks, according to new research published in the November 29, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The clinical trial, led by Mirnela Byku, MD, PhD, MBA, at the UNC School of Medicine, found that excluding aspirin from the antithrombotic regimen in patients with a levitated left ventricular assist device is safe.
A new Phase Ib/II study from researchers at The University of Texas MD Anderson Cancer Center and Moffitt Cancer Center found that combining sensitizing drugs with a specific form of radiation therapy may be more effective in patients with locally advanced pancreatic cancer, yielding a higher progression-free survival (PFS) and overall response rate (ORR).
A large proportion of patients who start taking ADHD medication, especially young adults, stop within the first year. However, people who use ADHD medicine for a long time and in higher-than-average doses seem to have a higher risk of some cardiovascular diseases.
A five-year, $2 million grant to study the pharmacological effects of the areca nut, commonly known as the betel nut, was awarded to a UTHealth Houston researcher by the National Institute on Drug Abuse, part of the National Institutes of Health (NIH).
Far too many antibiotics are used around the world. As a result, bacteria are becoming resistant. Curing bacterial diseases is becoming more difficult than before, because antibiotics are perhaps our foremost weapons in the fight against them.
Scientists at the University of Bath have used nature as inspiration in developing a new tool that will help researchers develop new pharmaceutical treatments in a cleaner, greener, and less expensive way.
Traditional cancer treatments such as chemotherapy and radiation can come with collateral damage. In the process of killing cancer, the treatments harm normal cells, too, leading to both short- and long-term side effects. Even today’s targeted drugs and immunotherapy can have effects on normal tissues.
Si usted corre el riesgo de enfermedad cardíaca, el equipo de atención médica podría utilizar la herramienta de la ecuación de cohorte agrupada para determinar su riesgo a largo plazo y si la administración de estatinas (medicamentos para reducir el colesterol) es una buena opción.
مدينة روتشستر، ولاية مينيسوتا—إذا كنت مهددًا بخطرالإصابة بمرض القلب فقد يستخدم فريق الرعاية الصحية أداة معادلة تقييم المخاطر المُشتركة بين الفئات العمرية(PCE) لتحديد خطر إصابتك على المدى الطويل وما إذا كان تناول أدوية خافِضة للكوليسترول — أدوية خفض الكوليستيرول، خيار مناسب لك أم لا.
Se você está sob o risco de ter uma doença cardíaca, a equipe de cuidados médicos pode usar a ferramenta de equação de coorte agrupada (PCE) para determinar o seu risco de longo prazo, e se a administração de estatinas (medicamentos para reduzir o colesterol) é uma boa opção.
Cancer cells with multiple mutations alter the function of cell competition and use it to enhance their own invasive ability.
New study finds that anti-rheumatic drugs used for rheumatoid arthritis might prevent the development of autoimmune thyroid disease.
Lidocaine activates certain bitter taste receptors through two unique mechanisms that result in cancer cell death, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. Their findings, published today in Cell Reports, pave the way for a clinical trial to test the addition of lidocaine to the standard of care therapy for patients with head and neck cancers.
The American Society for Pharmacology and Experimental Therapeutics (ASPET) has selected 16 individuals as 2023 ASPET Fellows.
Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.
Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer’s and found that differences in brain immunometabolism – the interactions between the immune system and the ways cells create energy – may contribute to women’s increased risk for the disease and its severity.
A new study shows that a drug that boosts bone growth in children with achondroplasia, the most common form of dwarfism, may also reduce their chances of sudden infant death syndrome (SIDS), sleep apnea, and needing surgery.
Proof of concept of new material for long lasting relief from dry mouth conditions
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right
