Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders
PreprintsFederica Forlanini, Alice Chan, Jasmeen Dara, Christopher C. Dvorak, Morton J. Cowan, Jennifer M. Puck, Morna J. Dorsey
Feature Channels: Stem Cells
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Released: 7-Apr-2022 12:00 PM EDT
Released: 7-Apr-2022 12:00 PM EDT
Association between cancer stem cell gene signature and prognosis in head and neck squamous cell carcinoma
PreprintsSu Il Kim, Seon Rang Woo, Joo Kyung Noh, Min Kyeong Lee, Young Chan Lee, Jung Woo Lee, Moonkyoo Kong, Seong-Gyu Ko, Young-Gyu Eun
Released: 7-Apr-2022 12:00 PM EDT
GATA2 as an outcome signature: promoting bladder cancer migration and inhibiting PD-L1 expression
PreprintsSiqing Sun, Jianbin Bi
Released: 7-Apr-2022 12:00 PM EDT
Hematopoietic stem cell-derived fibrocytes as targets and tools for cancer therapy: mechanisms and therapeutic implications
PreprintsLiyi Zhang, Haibo Qiu, Xu Zhang, Jiali Qi, Jiangwen Zhang, Yin Tong, Lei Li, Li Fu, Yan-Ru Qin, Xinyuan Guan
Released: 7-Apr-2022 11:05 AM EDT
UC San Diego Studying Cells in Space for Early Cancer Detection
UC San Diego Health
5-Apr-2022 10:05 AM EDT
Mount Sinai Develops Method to Advance Maturation of Human Pluripotent Stem Cell-Derived Heart Cells
Mount Sinai Health SystemNew study outlines scalable protocol to enhance development and understanding of human pluripotent stem cells in cardiac muscles
Released: 6-Apr-2022 4:20 PM EDT
Turmeric compound helps grow engineered blood vessels and tissues
University of California, RiversideA finding by UC Riverside bioengineers could hasten development of lab-grown blood vessels and other tissues to replace and regenerate damaged tissues in human patients.
Released: 6-Apr-2022 12:00 PM EDT
Production and preservation of serum-free human umbilical cord-derived mesenchymal stem cell sheets
PreprintsJuan Wang, Shuang Gao, Yufei Zhao, TaiBing Fan, Mingkui Zhang, Dehua Chang
Released: 6-Apr-2022 12:00 PM EDT
JAK/STAT3 Pathway Promotes Proliferation of Ovarian Aggregate-derived Stem Cells in vitro
PreprintsMaryam Saber, Faezeh Shekari, Seyed-Ahmad Mousavi, Ashraf Moini, Monireh-Sadat Miri, Fereshteh Esfandiari
Released: 6-Apr-2022 12:00 PM EDT
Effect of Human Platelet Lysate as Cultivation Nutrient Supplement on the Expansion of Human Natal Dental Pulp Stem Cells In Vitro
PreprintsNela Pilbauerova, Jan Schmidt, Tereza Suchankova Kleplova, Tomas Soukup, Jakub Suchanek
Released: 6-Apr-2022 12:00 PM EDT
Targeting senescent cells by dasatinib and quercetin ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration.
PreprintsYing Wang, Linbin Che, Xi Chen, Zirui He, Dianwen Song, Yuan Yuan, Changsheng Liu
Released: 5-Apr-2022 12:00 PM EDT
Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers
PreprintsMark Andreas Kluth, Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Jünger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schröder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank
Released: 5-Apr-2022 12:00 PM EDT
Low-intensity pulsed ultrasound/nanomechanical force generators enhance osteogenesis of bone marrow mesenchymal stem cells through microfilaments and transient receptor potential melastatin 7 activation
PreprintsHuan Yao, Liang Zhang, Shujin Yan, Yiman He, Hui Zhu, Yasha Li, Ke Yang, Dong Wang
Released: 5-Apr-2022 12:00 PM EDT
PDIA3P1 Promotes Temozolomide Resistance in Glioblastoma by Inhibiting C/EBPβ Degradation to Facilitate Proneural-to- Mesenchymal Transition
PreprintsZijie Gao, Jianye Xu, Yang Fan, Yanhua Qi, Shaobo Wang, Shulin Zhao, Xing Guo, Hao Xue, Lin Deng, Rongrong Zhao, Chong Sun, Ping Zhang, Gang Li
Released: 5-Apr-2022 12:00 PM EDT
Breast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands
PreprintsKatrin Raute, Juliane Strietz, Geoffroy Andrieux, Oliver S. Thomas, Klaus Maximilian Kistner, Marina Zintchenko, Peter Aichele, Houjiang Zhou, Wilfried Weber, Melanie Boerries, Mahima Swamy, Jochen Maurer, Susana Minguet
Released: 5-Apr-2022 12:00 PM EDT
Engineering Proprioceptive Implants via Surgical and Regenerative Approaches: Preliminary Interpretations
PreprintsSiddhartha Das, Haladhar Dev Sarma, Jayesh Bellare
Released: 5-Apr-2022 12:00 PM EDT
Machine Learning Classification Reveals Robust Morphometric Biomarker of Glial and Neuronal Arbors
PreprintsMasood A Akram, Qi Wei, Giorgio Ascoli
Released: 5-Apr-2022 12:00 PM EDT
Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development
PreprintsCody McKee, Peter Shrager, Arindam Mazumder, Archan Ganguly, Abigail Mayer, Karl Foley, Nancy Ward, Margaret Youngman, Mathieu Bollen, Hailong Hou, Houhui Xia
Released: 5-Apr-2022 12:00 PM EDT
Investigating the Role Of CRISPR In Treating Hematopoietic Malignancies
PreprintsDiya Tibrewal
Released: 5-Apr-2022 12:00 PM EDT
Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression
PreprintsNicole Amberg, Florian M Pauler, Carmen Streicher, Simon Hippenmeyer
Released: 5-Apr-2022 12:00 PM EDT
Transcriptional Heterogeneity and Cell Cycle Regulation as Central Determinants of Primitive Endoderm Priming
PreprintsJoshua M Brickman, Marta Perera, Silas Boye Nissen, Martin Proks, Sara Pozzi, Rita Soares Monteiro, Ala Trusina
Released: 5-Apr-2022 12:00 PM EDT
Mesenchymal Stem Cells Modified with Angiotensin Converting Enzyme 2 are Superior in Ameliorating Inflammation and Oxidative Stress in Diabetic Nephropathy
PreprintsShasha Lv, Shanshan Liu, Yun Sun, Jing Cheng, Fulin Dou, Qiaoying Xu, Yinghui Wang, Qingzhen Liu, Gang Liu
Released: 4-Apr-2022 12:00 PM EDT
Low cost methods for Hydra care v2
PreprintsCallen Hyland, Jennifer DeSantis
Released: 4-Apr-2022 12:00 PM EDT
Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA
PreprintsAurelie Carabalona, Henna Kallo, Liliia Andriichuk, MaryAnne Gonzalez, Ellinoora Elomaa, Florence Molinari, Christiana Fragkou, Pekka Lappalainen, Marja Wessels, Juha Saarikangas, Claudio Rivera
Released: 4-Apr-2022 12:00 PM EDT
Methanol fixed feeder layers altered the pluripotency and metabolism of bovine pluripotent stem cells
PreprintsWenqiang Xu, Ruifeng Hao, Jing Wang, Lingna Gao, Xuejie Han, Chen Li, Hui Zhang, Xueling Li
Released: 4-Apr-2022 12:00 PM EDT
Therapeutic options and clinical outcomes of 1261 patients with mantle cell lymphoma in China: a real-world retrospective multicenter analysis from Chinese Hematologist and Oncologist Innovation Cooperation of the excellent (CHOICE)
PreprintsQingqing Cai, Dongfeng Zeng, Yu Fang, Yue Fei, Rong Liang, Haige Ye, Yun Liang, Xiuhua Sun, Michael Wang, Huiqiang Huang, Lugui Qiu, Tiejun Gong, Donglu Zhao, Yuxuan Che, Jinni Wang, Panpan Liu, Yi Wang, Tao Pan, Yao Lv, Panruo Jiang, Xuzhao Zhang, Jintai Deng, Shuhua Yi, Yizi He, Ling Xiao, Huijuan Lv, Jiangfang Feng, Huan Xie, Jiacheng Qian, Huilai Zhang, Hui Zhou
Released: 3-Apr-2022 12:00 PM EDT
Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8
PreprintsNan Wang, Jing He, Xiaoyu Feng, Shengyou Liao, Yi Zhao, Fuchou Tang, Kehkooi Kee
Released: 1-Apr-2022 12:00 PM EDT
Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma
PreprintsLorenz Nierves, Jian Guo, Siyuan Chen, Janice Tsui, Anuli C Uzozie, Jonathan W Bush, Tao Huan, Philipp F Lange
Released: 1-Apr-2022 12:00 PM EDT
Autophagy slows the aging of Germline stem cells in Drosophila through modulation of E-cadherin
PreprintsBhupendra V Shravage, Nidhi Murmu
Released: 1-Apr-2022 12:00 PM EDT
Fyn interrupts telomere maintenance in stem cells by phosphorylating menin at tyrosine 603
PreprintsSouren Paul, Preston McCourt, Le Thi My Le, Joohyun Ryu, Wioletta Czaja, Ann Bode, Rafael Contreras-Galindo, Zigang Dong
Released: 1-Apr-2022 12:00 PM EDT
CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder
PreprintsSerena Tamura, Andrew D Nelson, Perry We Spratt, Henry Kyoung, Xujia Zhou, Zizheng Li, Jingjing Zhao, Stephanie S Holden, Atehsa Sahagun, Caroline M Keeshen, Congyi Lu, Elizabeth C Hamada, Roy Ben-Shalom, Jen Q Pan, Jeanne T Paz, Stephan J Sanders, Navneet Matharu, Nadav Ahituv, Kevin J Bender
Released: 1-Apr-2022 12:00 PM EDT
Dynamic tissue-specific H2Bub1 is required for human and mouse cardiogenesis
PreprintsSyndi Barish, Jeffrey Drozd, Kathryn Berg, Isabella Berglund-Brown, Labeeqa Khizir, Lauren Wasson, Christine Seidman, Jonathan Seidman, Sidi Chen, Martina Brueckner
Released: 1-Apr-2022 12:00 PM EDT
The expression of Lin28 in gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin in vitro and in vivo
PreprintsXian Li, Lihua Kang, Jiaqi Peng, Wenyan Han, Xiulan Su
Released: 1-Apr-2022 12:00 PM EDT
Human iPSC-Vascular Smooth Muscle Cell Spheroids Demonstrate Size-dependent Alterations in Cellular Viability and Secretory Function
PreprintsSara Islam, Jackson Parker, Biraja C. Dash, Henry Hsia
Released: 1-Apr-2022 9:00 AM EDT
In-vivo T-cell depleted reduced-intensity conditioned allogeneic haematopoietic stem-cell transplantation for patients with acute lymphoblastic leukaemia in first remission: results from the prospective, single-arm evaluation of the UKALL14 trial
The LancetBackground The outcome of chemotherapy in patients older than 40 years with acute lymphoblastic leukaemia is poor and myeloablative allogeneic haematopoietic stem-cell transplantation (HSCT) has a high transplant-related …
Released: 31-Mar-2022 4:00 AM EDT
Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence
Stem Cell Reports… Autologous limbal stem cell transplantation is highly successful, but impossible in cases of complete bilateral stem cell deficiency. In these … We found that a very low amount of stem cell-like cells remained 4 weeks after the stem cell deficiency model …
Released: 30-Mar-2022 7:00 AM EDT
Cutting the umbilical cord: Cancer stem cell-targeted therapeutics
Life Sciences… They may arise due to accumulation of mutations in adult stem cells, uptake of mutated DNA from an apoptotic cell, occurrence of a dedifferentiating mutation within a previously differentiated somatic cell, or induction of fusion between a stem …
Released: 30-Mar-2022 7:00 AM EDT
Strategy of Stem Cell Transplantation for Bone Regeneration with Functionalized Biomaterials and Vascularized Tissues in Immunocompetent Mice
ACS Biomaterials Science & Engineering… To further investigate whether the implanted functionalized sodium alginate hydrogels produced bioactive stem cell transplantation beds, we performed an H&E and a Masson staining of paraffin sections of subcutaneous composite cystic tissues …
Released: 30-Mar-2022 7:00 AM EDT
Modeling PCDH19-CE: From 2D Stem Cell Model to 3D Brain Organoids
International Journal of Molecular Sciences… Induced pluripotent stem cell (iPSC) technology has provided a complementary experimental approach for investigating the pathogenic mechanisms implicated in PCDH19-CE during neurogenesis and studying the pathology in a more …
Released: 30-Mar-2022 7:00 AM EDT
The Leucine Rich Repeat Kinase 2 Mutation G2019S Leads to a Reduced Antioxidant Response in Induced Pluripotent Stem Cell Derived Neural Stem Cells
ProQuest… Single cell technology has found a niche in stem cell biology and can be used for studying cellular diversity, identifying subpopulations in heterogeneous culture systems and stem cellbased disease models. There are many methods available for …
Released: 29-Mar-2022 12:00 PM EDT
Dual Specificity Phosphatase 1 (DUSP1) Provides Mechanistic Link Between Melanoma Cellular Plasticity and Drug Resistance
PreprintsVijayasaradhi Setaluri, Mithalesh K. Singh, Sarah Altameemi, Marcos Lares, Michael A. Newton
Released: 29-Mar-2022 12:00 PM EDT
Identification of RP11-770J1.4-CTXN1 as an immunomodulatory axis in Low-Grade Glioma
PreprintsQiyuan Zhuang, Chaxian Liu, Yihan Hu, Ying Liu, Yingying Lyu, Yuhen Liao, Liang Chen, Hui Yang, Ying Mao
Released: 29-Mar-2022 12:00 PM EDT
A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci
PreprintsAkiko Doi, Gianmarco D. Suarez, Rita Droste, H. Robert Horvitz
Released: 29-Mar-2022 10:05 AM EDT
2022 Virtual and Combined Regenerative Medicine Essentials Course and World Stem Cell Summit Meeting Set
Atrium Health Wake Forest BaptistThe Wake Forest Institute for Regenerative Medicine (WFIRM) and the Regenerative Medicine Foundation (RMF) for the second year will join forces for their annual meetings to be held in conjunction and virtually, kicking off on Monday, June 6 - 11. Early Bird Registration ends May 6.
Released: 29-Mar-2022 9:00 AM EDT
Johns Hopkins Researchers Identify a Potential Window for Treating ALS
Johns Hopkins MedicineJohns Hopkins Medicine researchers have found a possible window of opportunity during ALS treatment to target astrocyte abnormalities — a subtype of cells in the central nervous system.
Released: 28-Mar-2022 4:55 PM EDT
Study Underway to See if Stem Cells Derived from Fat Tissue Can Enhance Healing and Outcomes in Rotator Cuff Surgery
Hospital for Special SurgeryResearchers at HSS have launched a study to see if injecting a type of stem cell derived from a patient’s own fat tissue could improve healing and shoulder function after rotator cuff surgery. The cells are extracted from adipose, or fat tissue, in the patient’s abdomen.
Released: 28-Mar-2022 12:00 PM EDT
Effect of oxidative stress-induced autophagy on proliferation and apoptosis of hMSCs
PreprintsZhijun Liu, Shaojin Liu, Weipeng Zheng, Zhihao Liao, Sheng Chen, Hewei Wei
Released: 28-Mar-2022 12:00 PM EDT
TGFβ Treated Placenta Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated Ophthalmopathy
PreprintsHyun-Ah Shin, Mira Park, Jasvinder Paul Banga, Helen Lew
Released: 28-Mar-2022 12:00 PM EDT
Comprehensive bioinformatic analysis of the expression and prognostic significance of TSC22D domain family genes in acute myeloid leukemia
PreprintsXiaoqiang Xu, Xin Jin, Jiaxi Wang, Rui Sun, Meng Zhang, Xia Xiong, Danni Xie, Mingfeng Zhao
Released: 28-Mar-2022 12:00 PM EDT
Mutational Changes and Enhanced Cell Migration during Transformation of Breast Non-tumorigenic Cells to Tumorigenic Cells
PreprintsSeung Hyuk T. Lee, Joon Yup Kim, Peter Kim, Chia-Yi Su, Eun Hyun Ahn
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