A long-held assumption about asymmetrical division of stem cells has cracked. Researchers at the University of Oregon report that the mitotic spindle does not act alone -- that cortical proteins help to position a cleavage furrow in the right location.
For the first time, researchers at Fred Hutchinson Cancer Research Center have identified and isolated adult mammary stem cells in mice. Long-term implications of this research may include the use of such cells to regenerate breast tissue, provide a better understanding of the role of adult stem cells in breast cancer development, and develop potential new targets for anti-cancer drugs.
On August 23rd, a federal district judge issued a temporary ban on federal funding for embryonic stem cell research. Stem cell research holds great promise for the treatment of millions of Americans with debilitating and possibly fatal diseases, including diabetes and heart disease. Because of the court injunction, the NIH reports that it will not review grant applications involving stem cell research, and similar grants that are up for renewal will not be funded.
The American Association for Cancer Research (AACR), the world’s oldest and largest cancer research organization, reiterates its support for the responsible conduct of human embryonic stem cell research that, up until this week, was funded by the National Institutes of Health (NIH) and expresses concern that the recent Federal District Court injunction to block federal funding for human embryonic stem cell research is a setback for scientific discovery.
Obama's ruling helped government-funded U.S. researchers by enabling them to use the best possible existing embryonic stem cell lines in conducting their research. The court decision is unfortunate, because it threatens to impede the progress of regenerative medicine in our country.
A study led by a researcher at Albert Einstein College of Medicine of Yeshiva University has revealed a unique “partnership” between two types of bone marrow stem cells, which could lead to advances in regenerative medicine.
Adult stem cells that are vital for airway repair in the lung but that persist in areas where pre-cancerous lesions are found are associated with a poor prognosis in patients who develop cancer, even those with early stage disease, researchers at UCLA’s Jonsson Comprehensive Cancer Center have found.
Mayo Clinic investigators, with Belgian collaborators, have demonstrated that rationally “guided” human adult stem cells can effectively heal, repair and regenerate damaged heart tissue. The findings -- called “landmark work” in an accompanying editorial -- appear in today’s Journal of the American College of Cardiology.
Researchers at the Buck Institute for Age Research have successfully used human induced pluripotent stem cells (iPSCs) to treat rodents afflicted with Parkinson’s Disease (PD). The research validates a scalable protocol that can be used to manufacture the type of neurons needed to treat the disease and paves the way for the use of iPSC’s in various biomedical applications.
Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation.
The National Science Foundation has awarded $3 million to Georgia Tech to fund a unique research program on stem cell bio-manufacturing. The program is specifically focused on developing engineering methods for stem cell production, in order to meet the anticipated demand for stem cells.
Human embryonic stem (ES) cells and adult cells reprogrammed to an embryonic stem cell-like state—so-called induced pluripotent stem or iPS cells—exhibit very few differences in their gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers.
Patients with deadly glioblastomas who received high doses of radiation that hit a portion of the brain that harbors neural stem cells had double the progression-free survival time as patients who had lower doses or no radiation targeting the area, a study from the Radiation Oncology Department at UCLA’s Jonsson Comprehensive Cancer Center has found.
New research, published in the journal Development, by Dr. Anthony-Samuel LaMantia, professor of Pharmacology & Physiology and director of the newly formed GW Institute for Neuroscience, and his colleagues have identified the stem cells that generate three critical classes of nerve cells – olfactory receptors (ORNs), vomeronasal (VRNs) and gonadotropin releasing hormone (GnRH) neurons – that are responsible for enabling animals and humans, to eat, interact socially and reproduce.
Scientists at the UCLA Broad Stem Cell Research Center have described a population of cells that mark the very first stage of differentiation of human embryonic stem cells as they enter a developmental pathway that leads to production of blood, heart muscle, blood vessels and bone.
UNC researchers reveal how a protein called Tet1 helps stem cells keep their “stemness” in a paper published in Nature.
With more than 100 billion neurons and billions of other specialized cells, the human brain is a marvel of nature. It is the organ that makes people unique.
Cells from frozen human blood samples can be reprogrammed to an embryonic stem-cell-like state, according to Whitehead Institute researchers. These cells can be multiplied and used to study the genetic and molecular mechanisms of blood disorders and other diseases.
Stem cells in the brain remain dormant until called upon to divide and make more neurons. However, little has been known about the molecular guards that keep them quiet. Now scientists from the Salk Institute for Biological Studies have identified the signal that prevents stem cells from proliferating, protecting the brain against too much cell division and ensuring a pool of neural stem cells that lasts a lifetime.
A new study from researchers in Ottawa and Toronto suggests that a commonly used type of bone marrow stem cell may be able to help treat sepsis, a deadly condition that can occur when an infection spreads throughout the body.
NYU Langone Medical Center has received a $5.4 million shared facility award from the Empire State Stem Cell Board’s New York State Stem Cell Science (NYSTEM) program.
Following stem cell therapy, an adult patient experienced a new and previously unrecognized complication, which required removal of one of the kidneys, according to a case report appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).
A Florida State University researcher has identified the important role that a key protein plays in cell division, and that discovery could lead to a greater understanding of stem cells.
The International Society for Stem Cell Research (ISSCR) prepares for the opening of the largest international conference specifically for stem cell professionals at the ISSCR 8th Annual Meeting in San Francisco, CA USA.
The International Society for Stem Cell Research (ISSCR) announced today that it has launched “A Closer Look at Stem Cell Treatments“ (www.closerlookatstemcells.org), a Web site to arm patients, their families and doctors with information they need to make decisions about stem cell treatments.
A gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells, according to researchers from the Center for Stem Cell Biology and Regenerative Medicine and the Department of Medicine at Thomas Jefferson University.
A new synthetic Petri dish coating could overcome a major challenge to the advancement of human embryonic stem cell research, say University of Michigan researchers.
A previously unknown pattern in DNA methylation - an event that affects cell function by altering gene expression – has been uncovered for the first time by stem cell researchers at UCLA, a finding that could have implications in preventing some cancers and correcting defects in human stem cell lines.
For two decades, the laboratory mouse has been the workhorse of biomedical studies and the only mammal whose genes scientists could effectively and reliably manipulate to study human diseases and conditions.
Rensselear Polytechnic Institute to expand stem cell research capabilities with $2.45 million New York State Stem Cell Science program grant to outfit laboratories in the Center for Biotechnology and Interdisciplinary Studies.
Leading stem cell and vascular biology researcher Paul S. Frenette, M.D., has been named the first director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine of Yeshiva University. Dr. Frenette will spearhead Einstein’s efforts to build upon existing resources to create a premier stem cell research institute.
A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a three-dimensional scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted.
Human stem cells administered intravenously can restore alveolar epithelial tissue to a normal function in a novel ex vivo perfused human lung after E. coli endotoxin-induced acute lung injury (ALI), according to research from the University of California San Francisco.
According to Whitehead Institute researchers, oxygen levels in the lab can permanently alter human embryonic stem (ES) cells, inducing X chromosome inactivation in female cells. This indicates that the current methods of isolation and maintenance are suboptimal.
Scientists at The Wistar Institute offer a new explanation for the persistent ability of melanoma cells to self-renew, one of the reasons why melanoma remains the deadliest form of skin cancer. The concept of the “dynamic stemness” of melanoma can explain why melanoma cells behave like both conventional tumor cells and cancer stem cells.
Human adult stem cells injected around the damage caused by a heart attack survived in the heart and improved its pumping efficiency for a year in a mouse model, researchers at The University of Texas MD Anderson Cancer Center report online ahead of publication in Circulation Research. Injection of a patient’s own adult stem cells into the heart has shown some efficacy in assisting recovery after a heart attack in early human clinical trials, said study senior author Edward T. H. Yeh, M.D. “But nobody knows how they work, or how long the stem cells last and function in the heart,” Yeh said. “This study shows how one type of adult stem cell works.”
Human embryonic stem cells (hESCs) possess remarkable properties of self-renewal and pluripotency, the ability to become almost any kind of cell within the body. And yet they share the same genome or set of genes with lineage-committed cells, cells fated to be or do one thing.
Chemical Engineering professor Shashi Murthy awarded $1.9 million grant to develop innovative ways to isolate stem cells for regenerative medicine applications
For the first time, Whitehead Institute researchers converted established human induced pluripotent stem (iPS) cells and human embryonic stem (ES) cells to state that corresponds to that of mouse embryonic stem cells, which are more immature and have greater pluripotency, and are much easier to propagate and to manipulate than traditional human ES.
In findings that could one day lead to new therapies, researchers from The Scripps Research Institute have described some striking differences between the biochemistry of stem cells versus mature cells.
Whitehead Institute researchers identified the mechanism that the protein c-Myc uses to regulate gene transcription. c-Myc is frequently linked to cell proliferation in human cancers. This mechanism suggests potential approaches to limiting its activity and controlling tumor growth in c-Myc-mediated cancers.
The International Society for Stem Cell Research (ISSCR) will hold its 10th annual meeting June 13-16, 2012, in Yokohama, Japan, at the PACIFICO Yokohama. The meeting is co-sponsored by Japan Science and Technology Agency (JST) and the Center for iPS Cell Research and Application (CiRA), Kyoto University. It will mark the 10th anniversary of the Society’s annual meeting, and its first in Asia.
An examination of the world-wide use of hematopoietic stem cell transplantation (HSCT), which involves transplantation of blood stem cells derived from the bone marrow or blood, finds that there are significant differences in transplant rates between countries and continental regions by indication and donor type.
The Johns Hopkins University School of Medicine and the New York Stem Cell Foundation (NYSCF) are establishing a collaborative program to advance the development and use of stem cells in therapies for a wide range of diseases, the organizations announced today. The program will train researchers to use stem cells and foster joint research projects.
Researchers at NYU Langone Medical Center have created stem cells from the eggs of aging mice that could be used for reproductive purposes and regenerative medicine. The study, published in April issue of Aging Cell, found that even though the eggs from older females were slightly less efficient at making stem cells than those from younger females, the capacity to create stem cells was sustained.
Albert Einstein College of Medicine of Yeshiva University has been awarded $10 million from the National Institutes of Health (NIH) to expand its stem cell research capabilities.
Scientists at The Scripps Research Institute have solved the decade-old mystery of why human embryonic stem cells are so difficult to culture in the laboratory, providing scientists with useful new techniques and moving the field closer to the day when stem cells can be used for therapeutic purposes.
Researchers at the Cedars-Sinai Heart Institute have found in animals that infusing cardiac-derived stem cells with micro-size particles of iron and then using a magnet to guide those stem cells to the area of the heart damaged in a heart attack boosts the heart’s retention of those cells and could increase the therapeutic benefit of stem cell therapy for heart disease.
A new field of cancer research could explain why some cancers that appear to have been cured can rear their ugly head or spread to other organs. The answer, believe researchers at the University of Michigan Comprehensive Cancer Center, lies with a small number of cells within a tumor, called cancer stem cells.
Bony fish like the tiny zebrafish have a remarkable ability that mammals can only dream of: if you lop off a chunk of their heart they swim sluggishly for a few days but within a month appear perfectly normal. How they accomplish this - or, more importantly, why we can't - is one of the significant questions in regenerative medicine today.
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