Historically plastic surgery has been considered one of most competitive and highly sought after residency programs. While this remains true recent appearing wrinkles may be of concern, according to an article in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Researchers at The University of Texas MD Anderson Cancer Center have discovered a novel immunotherapy combination, targeting checkpoints in both T cells and myeloid suppressor cells, that successfully reprogrammed the tumor immune microenvironment (TIME) and significantly improved anti-tumor responses in preclinical models of pancreatic cancer.
Researchers at Washington University School of Medicine in St. Louis have identified an important transition point in the shift from chronic to aggressive leukemia.
In cancer patients with neutropenic fever, delaying antibiotic treatment past 60 minutes from the time of fever detection does not reduce the short-term chance of survival, according to a study in the American Journal of Medical Quality. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Nearly one-fourth of breast cancer patients who start breast reconstruction after mastectomy don't complete the reconstructive process. The concept of reconstructive burnout is introduced and discussed in a study in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.
A research team that studied Juneau’s early response to the pandemic has identified a number of factors that helped the Alaskan capital mitigate COVID-19’s impact on residents.
Patients with rheumatoid arthritis, lupus, and other rheumatic conditions are more at risk for complications and death from pneumonia, meningitis, and other bacterial infections, yet most have not been vaccinated against infection.
UT Southwestern physicians have developed an improved targeting method, four-tract tractography, to personalize MRI-guided, high-intensity focused ultrasound (HIFU) used at UTSW to treat medication refractory tremor in essential tremor and tremor-dominant Parkinson’s disease.
UT Southwestern immunologists have uncovered a key pathogenic event prompted by obesity that can trigger severe forms of nonalcoholic fatty liver disease and potential liver failure.
Researchers at the Princeton Plasma Physics Laboratory uncover the long-hidden process that helps explain why the Sun's corona can be vastly hotter than the solar surface that emits it.
High levels of ammonia in tumors leads to fewer T cells and immunotherapy resistance in mouse models of colorectal cancer, new findings from the University of Michigan Rogel Cancer Center revealed. Researchers found that ammonia inhibits the growth and function of T cells, which are vital for anti-tumor immunity. The findings appear in Cell Metabolism.
UT Southwestern researchers have identified the molecular function of 87 inherited genetic variants that affect the risk of prostate cancer, and the majority appear to control the activity of genes located far away from the risk variants themselves.
Physicists, engineers, and technicians at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory are rounding out the year with key developments to a house-sized particle detector that will begin capturing collision snapshots for the first time next spring. The state-of-the-art, three-story, 1,000-ton detector—known as sPHENIX—will precisely track particles streaming from collisions at the Relativistic Heavy Ion Collider (RHIC), a DOE Office of Science user facility for nuclear physics research.
In a new study evaluating the Mediterranean diet and adverse pregnancy outcomes, investigators from the Smidt Heart Institute at Cedars-Sinai found that women who conceived while adhering to the anti-inflammatory diet had a significantly lower risk of developing preeclampsia during pregnancy.
Scientists at the U.S. Department of Energy’s (DOE) Institute for Cooperative Upcycling of Plastics (iCOUP) have developed a new method for recycling high-density polyethylene (HDPE).
Argonne researchers put their stamp on 2022 with accomplishments as varied as quantum science, wearable medical sensors, and climate change resilience and recovery.
An analysis published today in the New England Journal of Medicine describes the significant benefits The Inflation Reduction Act offers to improve public health through tax credits and other financial incentives.
Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team from the National Eye Institute (NEI), part of the National Institutes of Health, printed a combination of cells that form the outer blood-retina barrier—eye tissue that supports the retina's light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study degenerative retinal diseases such as age-related macular degeneration (AMD).
Scientists at Washington University in St. Louis discovered that under Mars-like conditions, manganese oxides can be readily formed without atmospheric oxygen. The study from the laboratory of Jeffrey Catalano in Arts & Sciences was published Dec. 22 in Nature Geoscience.
For selected patients with knee osteoarthritis, unicompartmental (or "partial") knee arthroplasty (UKA) shortens the recovery time for two key measures of physical function, as compared with total knee arthroplasty (TKA), reports a randomized trial in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
While cluster headache is more common in men than in women, a new study suggests that the disorder may be more severe for women. The study is published in the December 21, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
In people with active secondary progressive multiple sclerosis (MS), hematopoietic stem cell transplants may delay disability longer than some other MS medications, according to a study published in the December 21, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study involved autologous hematopoietic stem cell transplants, which use healthy blood stem cells from a person’s own body to replace diseased cells.
One-hundred fifty years ago, Charles Darwin speculated that life likely originated in a warm little pond. There, Darwin supposed, chemical reactions and the odd lightning strike might have led to chains of amino acids that, over time, became more and more complex until the beginnings of life emerged.Ever since, researchers have investigated this type of pre-life or “prebiotic” chemistry, trying to figure out the chemical pathways that could have led from a pool filled with simple amino acids to bacteria, redwood trees and people.
Flu season came a month early this year in Tennessee and hit hard, disproportionately affecting children, according to Epidemic Intelligence Service (EIS) data gathered by the Centers for Disease Control and Prevention (CDC), Tennessee Department of Health and Vanderbilt University Medical Center.
Experts provide the first framework for treating a common and life-threatening metabolic complication of cancer known as hypercalcemia of malignancy in the Endocrine Society’s new Clinical Practice Guideline.
One of the most highly-attended workshops at the 2022 IEEE Quantum Week was organized by researchers from the Advanced Quantum Testbed (AQT) at Lawrence Berkeley National Lab (Berkeley Lab). Motivated by deep scientific inquiry and technological needs, the one-day hybrid workshop was titled “Classical Control Systems for Quantum Computing.”
Researchers have devised a new biomarker-based strategy to screen for a rare and deadly myocarditis complication caused by immune checkpoint inhibitors that are used to treat several cancers. In the study, nearly all patients with cancer who were treated with ICIs had early signs of muscle destruction and liver damage.
Researchers have developed a new method for discovering and making new crystalline materials with two or more elements. Such materials would be applicable to developing next-generation superconductors, microelectronics, batteries, magnets and more.
Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells—cells that control your heartbeat—can “fight back” against therapies to biologically correct abnormal heartbeat rates.
Medicare costs for treatment of metastatic prostate cancer have risen sharply within the last 15 years – reflecting increased use of new medications under Medicare Part D, reports a study in Urology Practice®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) in New York have discovered that common cancer treatments, such as radiotherapy or anthracycline drugs, cause long-term damage to heart tissue by activating a key inflammatory signaling pathway. The study, published December 19 in the Journal of Experimental Medicine (JEM), suggests that inhibiting this pathway could reduce the chances of cancer survivors suffering heart disease later in life.
The transition to telehealth-based care at the onset of the COVID-19 pandemic was followed by an increase in initiation of and engagement with specialty alcohol treatment, according to a study of health records at one large U.S. health system. The study, published in Alcoholism: Clinical and Experimental Research, found the greatest increases in odds of initiating treatment were among 18- to 34-year-olds, a group that has historically been less likely to seek treatment for alcohol problems. Notably, the transition to telehealth did not appear to worsen racial and ethnic disparities in treatment for alcohol problems and may have facilitated treatment for specific populations. The findings provide timely considerations for structuring post-pandemic models of health care for alcohol use problems.
Worries about what emergency care might cost them have kept some older adults from seeking medical attention even when they felt they might need it, a new study shows. In all, 22% of older adults who may have needed care from the emergency department didn’t go because of concerns about what they might have to pay.
New UCLA-led research finds that a college preparatory program for youth experiencing educational inequities that operates in about 13% of U.S public high schools has a positive effect on students’ social networks, psycho-social outcomes, and health behaviors. The findings, published Dec. 16 in the peer-reviewed journal Pediatrics, suggests that the Advancement via Individual Determination (AVID) program, aimed at increasing educational opportunities for under-represented and economically disadvantaged students, also significantly reduces substance use.
Fathers who acknowledge binge drinking are less involved with their children, according to new research in several countries that have traditionally been understudied. Globally, men are increasingly involved in children’s development. The latest analysis, in Alcoholism: Clinical & Experimental Research, explores fathers’ binge drinking in relation to the quality of their parenting, and suggests that preventing or treating heavy alcohol use among fathers may have broad benefits for families. Previous studies around the world have flagged the harms of parents’ problematic alcohol use on family relationships and children’s development. Paternal alcohol use disorder, depression, and marital satisfaction are known to be important for parenting. Heavy drinking, which is related to notions of masculinity, has been linked across cultures to more punitive parenting, child abuse and neglect, and intimate partner violence. Little is known about how heavy alcohol use impacts fathers’ relationships
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The latest guidance in addressing proper monitoring and reversal of neuromuscular blockade drugs during general anesthesia – a major advance in patient safety and satisfaction – was published today in Anesthesiology, the American Society of Anesthesiologist’s (ASA) peer-reviewed medical journal.
Astronomers have uncovered a pair of planets that are true "water worlds," unlike any planet found in our solar system. Slightly larger than Earth, they have global oceans at least 500 times deeper than the average depth of Earth's oceans.
Patients in the Emergency Room (ER) should be blood-tested for hazardous drinking rather than evaluated by questionnaires alone, according to a new study comparing alcohol use screening methods. A sizeable minority of patients attend the ER for alcohol-related reasons (12–15% in the UK). That proportion is growing, a US study has found. The ER offers valuable opportunities to identify hazardous drinking and intervene with treatments that can help patients reduce their alcohol use. This requires efficiently and reliably screening ER patients for risky consumption. Validated methods include the Alcohol Use Disorders Identification Test (AUDIT) — and its shorter version, AUDIT-C —which are among the most frequently used screening questionnaires. Another, the Timeline Followback Questionnaire (TLFB), is a retrospective self-administered survey estimating daily alcohol consumption over a specific prior period. In contrast, phosphatidylethanol (PEth), a metabolite of ethanol, is a direct and
People with cluster headaches may be more than three times more likely to have other medical conditions such as heart disease, mental disorders and other neurologic diseases, according to a study published in the December 14, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
When patients undergo any type of surgery after having had COVID, their odds of significant postoperative problems diminish with elapsed time from COVID diagnosis.
Researchers at Vanderbilt University Medical Center now report that this trend of decreasing risk persists longer than previously known, for as long as 13 months after surgery. Their report appeared Dec. 14 in JAMA Network Open.
The Q-NEXT quantum research center has released a quantum technology roadmap that outlines the research and scientific discoveries needed for distributing quantum information on a 10- to 15-year timescale.
The Association for Molecular Pathology (AMP), the premier global molecular diagnostic professional society, has published a report that was designed to assess clinical adoption, identify classification inconsistencies, and evaluate implementation barriers for the 2017 report, “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.” The AMP manuscript, “Assessments of Somatic Variant Classification Using the AMP/ASCO/CAP Guidelines” was released online ahead of publication in The Journal of Molecular Diagnostics.
In Physics of Fluids, researchers explore the lift production mechanism of flying snakes, which undulate side-to-side as they move from the tops of trees to the ground to escape predators or to move around quickly and efficiently. The investigators developed a computational model derived from data obtained through high-speed video of the snakes and considered several features, such as the angle of attack that the snake forms with the oncoming airflow and the frequency of its undulations, to determine which were important in producing glide.
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