Race-based assessments of lung function have historically assumed different levels of “normal” for different patient groups. New analysis shows that removing from lung function estimates would increase the number of Black patients diagnosed with serious disease.Greater estimated disease severity would change a patient’s diagnosis, disability compensation, eligibility for certain jobs.
Compared with pre-surgical (neoadjuvant) chemotherapy alone, adding perioperative immunotherapy – given before and after surgery – significantly improved event-free survival (EFS) in patients with resectable early-stage non-small cell lung cancer (NSCLC), according to researchers from The University of Texas MD Anderson Cancer Center.
Researchers from the Biological Threat Response Laboratory played a critical role in testing for the virus.
One of the most common genetic heart diseases worldwide, hypertrophic cardiomyopathy (HCM) causes the walls of the left ventricle to become thick and stiff. In about 70 percent of cases, patients with HCM experience obstruction to blood flow, which increases pressures in the heart and can lead to chest pain, shortness of breath and reduced exercise capacity.
Four proposed state-of-the art image search engines for automating search and retrieval of digital histopathology slides were found to be of inadequate performance for routine clinical care. Some had less than 50% accuracy, which is not suitable for clinical practice.
An international consortium published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).
In the first year after the sudden removal of a requirement that prescribers get special permission to prescribe medication for opioid addiction, a study finds more prescribers started providing it, but the number of patients receiving it didn't rise very much.
Roundup of recent research involving UT Southwestern faculty members: Antibody treatment lowers risk for food allergies; Weight-loss surgery support offered for teens; Racial disparities found among pregnant patients with multiple sclerosis; Gestational age increased at start of COVID-19 pandemic
Dana-Farber Cancer Institute has implemented an artificial intelligence (AI) application intended for general use in a medical center or hospital.
Patient education about flu shot during a non-life threatening emergency department visit increases vaccination rates, especially in patients without regular primary care.
A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators.
Resmetirom (Rezdiffra) is the first drug approved for treating MASH, an advanced form of fatty liver disease. UChicago Medicine experts contributed to a recent clinical trial and will begin incorporating the drug into liver disease treatment regimens for eligible patients.
The UCLA Department of Medicine is pleased to announce that Priscilla Hsue, MD will be joining us as the chief of the Division of Cardiology at UCLA, effective July 1, 2024.
A blood test intended for screening for colorectal cancer in people who are of average risk and not experiencing symptoms correctly detected colorectal cancer in 83% of people confirmed to have the disease, according to a study published March 14 in the New England Journal of Medicine.
Combining the anticancer drugs enfortumab vedotin and pembrolizumab (EV+P) led to significantly improved survival rates among patients with advanced urothelial cancer (the most common type of bladder cancer) compared with standard chemotherapy, according to results of a large international clinical trial involving 185 sites, including the Johns Hopkins Kimmel Cancer Center’s Greenberg Bladder Cancer Institute, in 25 countries.
The FDA has approved two medications for the treatment of eosinophilic esophagitis (EoE)—the first oral medication tailored for adults and the exclusive therapeutic option for children. Evan Dellon, MD, MPH, internationally known for his work with EoE, and colleagues continue to focus on optimizing usage for effective, personalized outcomes.
Published in the New England Journal of Medicine, Seth A. Berkowitz, MD, MPH, associate professor of medicine at the UNC School of Medicine, wrote perspective piece on how medically tailored meals address health consequences of food insecurity.
Children’s Healthcare of Atlanta and Emory University participated in a nationwide clinical trial showing that a 16-week course of omalizumab, an injectable drug, increased the amount of peanut, tree nuts, egg, milk and wheat that some multi-food allergic children as young as one year could consume without an allergic reaction after exposure.
A study led by Johns Hopkins Children’s Center shows omalizumab — an injectable, Food and Drug Administration (FDA)-approved medication for treating asthma and other allergic conditions — substantially reduced potentially life-threatening reactions in patients with an allergy to peanut and other common food allergies.
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An international team, including researchers from McMaster University and St. Joseph’s Healthcare Hamilton, has identified a new therapeutic for patients with a rare autoimmune disease called eosinophilic granulomatosis with polyangiitis (EGPA). A biologic drug called benralizumab has been shown to be non-inferior to mepolizumab in the treatment of EGPA.
Results of 16-Center REVIVE trial published in The New England Journal of Medicine
The UCLA team played a pivotal role in a clinical trial that led to the FDA granting accelerated approval of the first antibody drug conjugate (ADC), mirvetuximab soravtansine, for the treatment of platinum-resistant ovarian cancer.
In a major, international study, named SELECT2, a University Hospitals (UH) research team found that patients with large strokes had a dramatically better recovery after endovascular thrombectomy plus medical management at long-term follow-up, than patients who only received standard medical management.
A life-threatening mold infection known as health care-associated Fusarium solani meningitis can be associated with a delayed, but devastating, injury to the brainstem and its blood supply among those infected, according to physicians from UTHealth Houston.
A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher.
A large multicenter clinical trial co-led by University of Maryland School of Medicine researchers found that an antiseptic containing iodine resulted in about one-quarter fewer post-surgical infections in patients with limb fractures compared to another frequently used skin antiseptic.
Researchers of the PREPARE trial, which enrolled nearly 8,500 participants at 25 hospitals in Canada and the United States, found the use of iodine povacrylex in alcohol to disinfect a patient’s skin could prevent surgical site infection in thousands of patients undergoing surgery for a closed fracture each year.
Researchers from The University of Texas MD Anderson Cancer Center reported promising results in a Phase I/II trial of 37 patients with relapsed or refractory B-cell malignancies who were treated with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cell therapy targeting CD19.
Embargoed research finds an average of 22 adolescents 14 to 18 years of age died in the U.S. each week in 2022 from drug overdoses, raising the death rate for this group to 5.2 per 100,000-- driven by fentanyl in counterfeit pills. The researchers also found 19 "hotspot" counties with particularly high overdose deaths.
In a new case study published in New England Journal of Medicine Catalyst’s January 2024 issue, UC Davis Health shared a road map for increasing workforce diversity across the health care industry.
A research team from Odense University Hospital and the University of Southern Denmark has developed an innovative screening test. With a blood sample from the expectant mother, they can scrutinize all the genes in the fetus.
The widespread use of cannabis (marijuana) and its increased potency are associated with a rise in cannabis-related psychiatric conditions, according to a new University of Maryland School of Medicine (UMSOM) review article that was recently published in the New England Journal of Medicine. It highlights the urgent need for doctors to screen for and treat patients who are experiencing symptoms of cannabis use disorder, which means they are experiencing significant problems from their use of the drug.
Researchers at St Vincent’s Institute of Medical Research (SVI) in Melbourne have shown that a commonly prescribed rheumatoid arthritis drug can suppress the progression of type 1 diabetes. The world-first human trial, published today in the New England Journal of Medicine and led by SVI’s Professor Thomas Kay, showed that a drug called baricitinib can safely and effectively preserve the body’s own insulin production and suppress the progression of type 1 diabetes in people who initiated treatment within 100 days of diagnosis.
A study from Washington University School of Medicine in St. Louis and Mid-America Transplant showed that the long-standing practice of treating deceased organ donors with thyroid hormone does not help preserve heart function, may cause harm and should be discontinued.
Researchers found that a test using salt infusion is more reliable than a test using arginine infusion to differentiate between excessive fluid ingestion and vasopressin deficiency.
An international clinical trial led by physician Jeffrey L. Carson, distinguished professor of medicine at Rutgers Robert Wood Johnson Medical School, found that a liberal blood transfusion given to patients who have had a heart attack and have anemia may reduce the risk of a reoccurrence and improve survival rates.
Convalescent plasma reduces COVID-19 mortality by 10% in patients on artificial ventilation
Patients with a dysfunctional aortic heart valve who received a new, prosthetic valve through a minimally invasive procedure had similar outcomes at five years as those who underwent open-heart surgery, a new study shows.
A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center.
The FDA today announced approval of a therapy giving thousands of patients hope for an alternative to amputation of their legs.
UChicago Medicine Comer Children’s Hospital was one of three sites to enroll patients in a clinical trial to test a potentially curative stem cell gene therapy for sickle cell disease. The results were promising.
Lesbian, gay, bisexual, transgender, queer, intersex and additional sexual and gender minority (LGBTQI+) people in every region of the world face marginalization and oppression.
Results from a large-scale clinical trial could increase usage of high resolution imaging for guiding interventional coronary procedures
Semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with heart failure with preserved ejection fraction (HFpEF) and obesity, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.
In 2017, the teams of Massimo Terzolo and Martin Fassnacht published a study in the New England Journal of Medicine that provided evidence for the efficacy of Mitotane in the prevention of recurrence in adrenocortical carcinoma.
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