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Released: 26-Oct-2022 12:00 PM EDT
Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation
World Journal of Stem Cells

BACKGROUNDWound healing impairment is a dysfunction induced by hyperglycemia and its effect on endothelial precursor cells (EPCs) in type 2 diabetes mellitus. There is increasing evidence showing that exosomes (Exos) derived from adipose-derive

Released: 26-Oct-2022 12:00 PM EDT
Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells
World Journal of Stem Cells

BACKGROUNDThe effects of inappropriate dietary calcium intake in early life on later obesity have not been fully elucidated. AIMTo raise the mechanism of maternal calcium intake on the multi-differentiation potential of mesenchymal stem cells

Newswise: Synthetic Genetic Circuits Reprogram Plant Roots
Released: 26-Oct-2022 11:35 AM EDT
Synthetic Genetic Circuits Reprogram Plant Roots
Department of Energy, Office of Science

Controlling gene activity is important for engineering plants for improved bioenergy crops and other applications. This research developed synthetic genes that use Boolean logic gates to achieve specific patterns of gene expression within a plant. The researchers used these gene circuits to redesign the root architecture by tuning the number of root branches.

Newswise:Video Embedded fau-lands-1-2-million-nsf-grant-to-transform-prosthetic-hand-control
VIDEO
Released: 26-Oct-2022 8:30 AM EDT
FAU Lands $1.2 Million NSF Grant to Transform Prosthetic Hand Control
Florida Atlantic University

Current prosthetic hands have five individually actuated digits, yet only one grasp function can be controlled at a time, which makes sophisticated tasks largely impossible.

Newswise:Video Embedded saliva-genomic-analysis-used-to-identify-promising-biomarkers-for-persistent-post-concussive-symptoms-in-children
VIDEO
Released: 26-Oct-2022 12:05 AM EDT
Saliva, Genomic Analysis Used to Identify Promising Biomarkers for Persistent Post-Concussive Symptoms in Children
Nationwide Children's Hospital

In a study published in Frontiers in Public Health, researchers at Nationwide Children’s Hospital have demonstrated a method by which increased risk of persistent post-concussive symptoms (PPCS) in children with concussion can be identified. This could allow families and their care teams to better assess recovery time of children with concussion.

Newswise: Magnetic Sensors Track Muscle Length
Released: 25-Oct-2022 5:30 PM EDT
Magnetic Sensors Track Muscle Length
Massachusetts Institute of Technology (MIT)

Using a simple set of magnets, MIT researchers have come up with a sophisticated way to monitor muscle movements, which they hope will make it easier for people with amputations to control their prosthetic limbs.

Released: 25-Oct-2022 12:55 PM EDT
COUR Pharmaceuticals Announces FDA Clearance of Investigational New Drug Application for Myasthenia Gravis
COUR Pharmaceuticals

COUR Pharmaceuticals, a clinical-stage biotechnology company developing novel immune-modifying nanoparticles designed to reprogram the immune system for the treatment of autoimmune disorders (COUR NanoParticles or CNPs), today announced that the U.S. Food and Drug Administration has cleared an Investigational New Drug (IND) application to initiate a Phase 1b/2a proof-of-concept study of COUR's investigational therapy, CNP-106.

Released: 24-Oct-2022 5:15 PM EDT
The New York Stem Cell Foundation Names Dr. Derrick Rossi as Interim CEO
New York Stem Cell Foundation (NYSCF)

The New York Stem Cell Foundation (NYSCF) announced Dr. Derrick Rossi, a member of the NYSCF Board of Directors and co-founder of Moderna, as Interim CEO of NYSCF.

Released: 24-Oct-2022 10:05 AM EDT
SMU biotech research moving into Dallas' Pegasus Park
Southern Methodist University

SMU will have space in the Pegasus Park Tower, the centerpiece of a 23-acre mixed-use office campus for biotech firms and nonprofit organizations. Pegasus Park is within minutes of downtown Dallas and the UT Southwestern Medical District.

Newswise: Medical Conference: Italian and American Perspectives on Cancer Care
Released: 21-Oct-2022 4:05 PM EDT
Medical Conference: Italian and American Perspectives on Cancer Care
Sbarro Health Research Organization (SHRO)

The Sbarro Health Research Organization (SHRO), in collaboration with Temple University’s College of Science and Technology, the National Italian American Foundation (NIAF), and the Giovan Giacomo Giordano Foundation will host the Medical Conference titled “Italian and American Perspectives on Cancer Care” on Saturday October 29th at 9:00 AM at the Omni Shoreham Hotel in Washington, DC.

Released: 21-Oct-2022 3:15 PM EDT
New-Generation Tests. Russian Scientists Created a Platform for New-Generation Express-Tests on the Base of Crispr-cas12
Scientific Project Lomonosov

The development of molecular biology and biotechnologies made it possible to create a lot of biosensors and diagnostic tests – from fast analyses on COVID-19 to express-tests on pathogens, striking agricultural plants. Scientists from The Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences created a platform DIRECT2, that can give birth to new-generation express tests on the base of system CRISPR-Cas12, and demonstrated its work on the example of DNA Dickeya solani – a bacterium, that harms agricultural plants.

Released: 21-Oct-2022 12:00 PM EDT
Short-term exposure of human minor salivary gland stem cells to hypergravity enhances stemness
Preprints

Jeong-Seok Choi, Tri Ho Minh, Jeong Mi Kim, Mi Eun Choi, Eun Jeong Jeon, Jin-Mi Park, Sungryeal Kim, Young Mo Kim

Released: 20-Oct-2022 12:00 PM EDT
Recovery of physical function, muscle mass and quality of life in patients undergoing allogeneic hematopoietic stem cell transplantation
Preprints

Takahiro Takekiyo, Atae Utsunomiya, Souichiro Nara, Nozomi Mori, Norihisa Nakashima, Toshiyuki Okamura, Masahito Tokunaga, Takayoshi Miyazono, Nobuaki Nakano, Yoshikiyo Ito, Koichiro Dozono

Released: 20-Oct-2022 12:00 PM EDT
3D genome topologies distinguish pluripotent epiblast and primitive endoderm cells in the mouse blastocyst
Preprints

Gesa Loof, Dominik Szabo, Vidur Garg, Alexander Kukalev, Luna Zea-Redondo, Rieke Kempfer, Thomas M Sparks, Yingnan Zhang, Christoph J Thieme, Silvia Carvalho, Anja Weise, Milash Balachandran, Thomas Liehr, Lonnie R Welch,

Released: 20-Oct-2022 12:00 PM EDT
Architected Hydrogels for Functional Tissue Engineering Applications
Preprints

Doris Zauchner, Monica Zippora Müller, Sophie Zengerle, Adam Aleksander Korczak, Muriel Alexandra Holzreuter, Xiao-Hua Qin

Released: 20-Oct-2022 12:00 PM EDT
Parishin A-loaded Mesoporous Silica Nanoparticles Modulate Macrophage Polarization to Attenuate Tendinopathy
Preprints

Yan Liu, Lisha Zhu, Shanshan Jin, Yu Wang, Yuting Niu, Ming Yu, Zixin Li, Liyuan Chen, Xiaolan Wu, Chengye Ding, Tianhao Wu, Xinmeng Shi, Yixin Zhang, Dan Luo

Released: 20-Oct-2022 12:00 PM EDT
Comprehensive analysis of m6A related gene mutation characteristics and prognosis in colorectal cancer
Preprints

Tao Jiang, Linshuai Xing, Lipeng Zhao, Ziqi Ye, Dong Yu, Shengtao Lin

Released: 20-Oct-2022 12:00 PM EDT
KLF2 regulates neural differentiation of dental pulp-derived stem cells by modulating autophagy and mitophagy
Preprints

Hiranmoy Das, Prateeksha Prateeksha, Prathyusha Naidu, Manjusri Das, Derek Barthels

Released: 18-Oct-2022 12:00 PM EDT
Ostrich Eggshell – Hydroxyapatite Composite as a Safe Scaffold with Osteoinductive Properties
Preprints

Farideh Alahgahi, Esmail Fattahi, Mohsen Saeidi, Mir Mahmoud Mortazavi

Released: 17-Oct-2022 12:00 PM EDT
Development of a highly sensitive immunoassay to measure ataxin2 as a target engagement marker in Spinocerebellar Ataxia Type 2
Preprints

Jessica Bux, Nesli Ece Sen, Isa-Maria Klink, Stefan Hauser, Ludger Schöls, Georg Auburger, Olaf Horst Riess, Jeannette Hübener-Schmid

Released: 17-Oct-2022 12:00 PM EDT
Human organoid model of PCH2a recapitulates brain region-specific pathology
Preprints

Theresa Kagermeier, Stefan Hauser, Kseniia Sarieva, Lucia Laugwitz, Samuel Groeschel, Wibke Janzarik, Zeynep Yentuer, Katharina Becker, Ludger Schoels, Ingeborg Kraegeloh-Mann, Simone Mayer

Released: 17-Oct-2022 12:00 PM EDT
Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings
Preprints

Alexander Phillip Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun de Boer, Gary R Mirams, David J Christini, Trine Krogh-Madsen

Released: 17-Oct-2022 12:00 PM EDT
Type 2 Inflammation Drives an Airway Basal Stem Cell Program Through Insulin Receptor Substrate Signaling
Preprints

Xin Wang, Nils Hallen, Minkyu Lee, Sachin Samuchiwal, Qihua Ye, Kathleen Buchheit, Alice Maxfield, Rachel Roditi, Regan Bergmark, Neil Bhattacharyya, Tessa Ryan, Deb Gakpo, Soumya Raychaudhuri, Dan Dwyer,

Released: 17-Oct-2022 12:00 PM EDT
MicroRNAs 7/17/155 As A Potential Breast Tumor Stemness miRNA Cluster: Detection of Breast Cancer Grade Specific miRNA-mRNA Interaction Network Inspiration from Mammary Gland Development
Preprints

Saeed Khodayari, Hamid Khodayari, Haniyeh Jallali, Elnaz Saeedi, Ali Faryabi, Meghdad Yeganeh, Ahad Mohammadnejad, Amirnader Emami Razavi, Mohammad Dashtkoohi, Farimah Hadjilooei, Reza Shirkoohi, Ramesh Omranipour, Karim Nayernia, Habibollah Mahmoodzadeh

Released: 17-Oct-2022 12:00 PM EDT
Poly(ε-caprolactone)-based nanofibrous scaffold incorporated with decellularized bone extracellular matrix as a potential strategy for bone regeneration
Preprints

Ming Zhang, Quan Zhou, Qiangsheng Dong, Jue Zhang, Xin Zhou, Hao Huang, Junchen Bao, Hongjian Shan, Furong Sun, Liangliang Li

Released: 17-Oct-2022 12:00 PM EDT
Single-cell Landscape Analysis of the Circulating Human B Cell Pool under Selective Pressure of Allogeneic Stem Cell Transplantation
Preprints

Jonathan C Poe, Jiyuan Fang, Dadong Zhang, Marissa R Lee, Rachel A DiCioccio, Hsuan Su, Xiaodi Qin, Jennifer Zhang, Jonathan Visentin, Sonali J Bracken, Vincent T Ho, Kathy S Wang, Jeremy J Rose, Steven Z Pavletic,

Released: 17-Oct-2022 12:00 PM EDT
Mitochondrial complex I controls blood brain barrier permeability
Preprints

Gavin M Davis, Estelle Juere, Jerrard M Hayes, Gavin P Davey

Released: 17-Oct-2022 10:05 AM EDT
Protein IDs, drug candidates, show promise for COVID science
Cornell University

A highly innovative method using the latest technology has generated a comprehensive list of SARS-CoV-2 viral and human proteins that interact with each other, with one such interaction showing the virus directly influencing proteins that regulate the human immune system.

   
Released: 14-Oct-2022 12:00 PM EDT
A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals
Preprints

Jorge Lazaro, Maria Costanzo, Marina Sanaki-Matsumiya, Charles Girardot, Masafumi Hayashi, Katsuhiko Hayashi, Sebastian Diecke, Thomas B Hildebrandt, Giovanna Lazzari, Jun Wu, Stoyan G Petkov, Rudiger Behr, Vikas Trivedi, Mitsuhiro M

Released: 14-Oct-2022 12:00 PM EDT
Gamma Irradiation Processing on 3D PCL Devices - A Preliminary Biocompatibility Assessment
Preprints

Fernando Guedes, Mariana V. Branquinho, Sara Biscaia, Rui D. Alvites, Ana C. Sousa, Bruna Lopes, Patrícia Sousa, Alexandra Rêma, Irina Amorim, Fátima Faria, Tatiana M. Patrício, António Bugalho, Nuno Alves, Ana C. Maurício

Released: 14-Oct-2022 12:00 PM EDT
An integrated cell barcoding and computational analysis pipeline for scalable analysis of differentiation at single-cell resolution
Preprints

Sophie Shen, Tessa Werner, Yuliangzi Sun, Woo Jun Shim, Samuel Lukowski, Stacey Andersen, Han Sheng Chiu, Di Xia, Xiaoli Chen, Duy Pham, Zezhuo Su, Joseph E Powell, Patrick P. L. Tam, Mikael Boden,



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