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Article ID: 700282

Duchenne Muscular Dystrophy: How Muscle Cells Journey to the Dark Side

Sanford Burnham Prebys Medical Discovery Institute

Answers to treating muscular dystrophies could lie in better understanding muscle repair—which resembles a delicate cellular dance choreographed by special cells called fibro-adipogenic progenitors (FAPs). Researchers already know these cells have a dark side—they are also responsible for the muscle wasting and scarring that occurs during Duchenne muscular dystrophy (DMD). Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have revealed that FAPs don’t have just one identity—but several distinct identities that emerge during key stages of muscle regeneration. Importantly, the FAPs that drive the symptoms of DMD have defined markers, meaning they could be targeted for drug development. The study was published in Nature Communications.

Released:
11-Sep-2018 8:00 AM EDT
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Article ID: 700292

MD Anderson immunotherapy expert Sharma wins Coley Award

University of Texas M. D. Anderson Cancer Center

Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at The University of Texas MD Anderson Cancer Center, has been recognized for her innovative work understanding factors that enhance and hinder cancer immunotherapy. Sharma will receive the William B. Coley Award for Distinguished Research in Tumor Immunology, awarded annually by the Cancer Research Institute (CRI), at an annual meeting co-sponsored by CRI in New York Sept. 30 to Oct. 3.

Released:
11-Sep-2018 8:00 AM EDT
  • Embargo expired:
    11-Sep-2018 5:00 AM EDT

Article ID: 700230

Researchers Identify a Potential Strategy in Fight Against Brain Cancer

Virginia Tech

Scientists with the Virginia Tech Carilion Research Institute say a gene involved in the body’s sleep cycle is a potential target for therapies to help patients with a deadly form of brain cancer known as glioblastoma. This discovery, to be published in the journal Scientific Reports on Tuesday, Sept. 11, points to a subtype of a particular gene that apparently is enabling the survival of cancer cells, although it is more commonly associated with circadian rhythms — the body’s 24-hour biological clock.

Released:
10-Sep-2018 8:45 AM EDT
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Article ID: 700275

Zika Virus Strips Immune Cells of Their Identity

University of California San Diego Health

Macrophages are immune cells that are supposed to protect the body from infection by viruses and bacteria. Yet Zika virus preferentially infects these cells. Researchers at University of California San Diego School of Medicine have now unraveled how the virus shuts down the genes that make macrophages function as immune cells.

Released:
10-Sep-2018 3:05 PM EDT
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  • Embargo expired:
    10-Sep-2018 11:00 AM EDT

Article ID: 700047

McMaster study identifies an unexpected cell population key to blood cancer relapse

McMaster University

The study published today in the journal Cancer Cell suggests that leukemia cells change in unique ways in response to the chemotherapy, allowing them to masquerade for a short time so they are able to start disease regeneration.

Released:
5-Sep-2018 2:05 PM EDT
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  • Embargo expired:
    10-Sep-2018 11:00 AM EDT

Article ID: 700241

Optimizing Technologies for Discovering Cancer Cell Mutations

Penn State College of Medicine

A team of researchers has developed a new framework that can combine three existing methods of finding mutations -- or structural variants -- in the DNA of cancer cells into a single, more complete picture.

Released:
10-Sep-2018 11:00 AM EDT
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Article ID: 700243

A “reset” of regulatory T-cells reverses chronic heart failure in mouse model

University of Alabama at Birmingham

In mouse experiments, scientists have shown a way to hit an immunological “reset button” that ends inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure.

Released:
10-Sep-2018 10:05 AM EDT
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Article ID: 700222

Changes in the Architecture Around Cancer Cells Can Fuel Their Spread

University of California, Los Angeles (UCLA), Health Sciences

UCLA researchers have found that an often overlooked component of a cell, the extracellular matrix, can influence how much sugar the cell consumes and its migratory behavior.

Released:
7-Sep-2018 4:55 PM EDT
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Article ID: 700214

Chronic Diseases Driven by Metabolic Dysfunction

University of California San Diego Health

Progress in treating chronic illness, where the cause of the problem is often unknown, has lagged. Chronic conditions like cancer, diabetes and cardiovascular disease defy easy explanation, let alone remedy. In a new paper, a researcher at University of California San Diego School of Medicine, posits that chronic disease is essentially the consequence of the natural healing cycle becoming blocked, specifically by disruptions at the metabolic and cellular levels.

Released:
7-Sep-2018 2:05 PM EDT
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  • Embargo expired:
    7-Sep-2018 12:15 AM EDT

Article ID: 699947

NYS Sepsis Reporting Mandate Appears to Improve Care, Reduce Deaths

American Thoracic Society (ATS)

A New York State requirement that all hospitals report compliance with protocols to treat severe sepsis and septic shock appears to improve care and reduce mortality from one of the most common causes of death in those who are critically ill, according to a new study published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

Released:
4-Sep-2018 4:00 PM EDT

Showing results 5160 of 5846

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