The adult neurogenic niche in the hippocampus is maintained through activation of reversibly quiescent neural stem cells (NSCs) with radial glia-like morphology (RGLs). Here, we show that the expression of SoxD transcription factors Sox5 and Sox6 is …
… A meta-analysis including 7673 patients undergone to TAVR demonstrated that low stroke-volume index, a parameter of transaortic flow, was related with an increased mortality compared with patients with normal stroke volume index [36] …
Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLCs) have shown great potential as an alternative to primary human hepatocytes (PHHs) for in vitro modeling. Several differentiation protocols have been described to direct PSCs toward the …
… To generate pancreatic β cells, we used human induced pluripotent stem cell lines generated from a chemical reprogramming approach 20,21 , which used extrinsic chemical stimulation to manipulate cell fate by exposing the somatic cells to …
… Recent progress in stem cell biology has enabled the generation of “organoids” from pluripotent stem cells (PSCs), but most of the currently available organoids lack the organotypic “higher-order structure”, in which functional units are distributed at …
… Over the last 15 years, we have developed Stem Cell Educator™ therapy for its immediate clinical translational potential to successfully … This comprehensive review will focus on the current progresses of Stem Cell Educator therapy for the …
… modulatory effect on stem cell differentiation, … stem cell differentiation while control of cell adhesion morphology could be used to determine the direction of differentiation, so that the two in combination might be able to replace the chemical …
… By engineering a stem cell niche within capsules loaded with very few hiPSCs and by imaging them over long time periods, we solve this puzzle. We find that hiPSCs initially form cysts that grow and thicken, become pseudo-stratified epithelia …
Leukemia stem cells (LSCs) propagate leukemia and are responsible for the high frequency of relapse of treated patients. The ability to target LSCs remains elusive, indicating a need to understand the underlying mechanism of LSC formation. Here …
… TAVR is an important therapy for the treatment of severe symptomatic aortic stenosis. Despite … TAVR technology, periprocedural stroke remains a complication of TAVR and is associated with morbidity and mortality even in younger low-risk …
… We expected the immune reconstitution after stem cell transplantation to differentially affect the blood compartment versus the peripheral tissues. We therefore performed immune monitoring of multiple immune cell subsets in both …
… a stem cell-independent manner. Mast cells are proposed to originate from intraembryonic hemogenic endothelium, though it is obscure whether the mast cell development is stem cell… develop from intraembryonic hemogenic endothelial …
… stem cell viability in real-time in vivo. Using this method, we successfully sought two small molecules including glutathione and dexamethasone that could improve stem cell … Therefore, we provide a potential strategy for real-time in vivo …
… to increased CXCL12 expression and haematopoietic stem cell quiescence. Consequently, nicotine exposure increases endosteal haematopoietic stem cell quiescence in vivo and impairs hematopoietic regeneration after haematopoietic …
… tests noninferiority of TAVR versus surgical aortic valve replacement for a primary endpoint composed of 1-year all-cause mortality, all stroke, and rehospitalization, among women with severe aortic stenosis. Second, patient’s selection remains the …
For several hours on Monday, January 31, 2022, a misleading article from news agency Reuters lead to many readers sharing the report on social media as conclusive evidence of ivermectin’s effectiveness against COVID-19, and proof of the alleged conspiracy of suppressed research to blame for the anti-parasite drug’s current lack of approval by the United States Food & Drug Administration.
Huge loss in the pandemic for the last two years, everyone is looking for fresh start in 2022. Meditation is proven technique to help keep your mind stable.
… stem cell spheroids to facilitate their aggregation and promote osteogenesis for bone tissue-engineering applications. We developed bone marrow mesenchymal stem cell (… Altogether, the results obtained from the current study offer an operative …
… The objective of this study is to evaluate the long-term effects of nanoscale iron oxide exposure on human pluripotent stem cell-derived cortical spheroids that mimic human forebrain-like tissue development. In particular, the cortical spheroids were …
… A meta-analysis including 7673 patients undergone to TAVR demonstrated that low stroke-volume index, a parameter of transaortic flow, was related with an increased mortality compared with patients with normal stroke volume index [36] …
… We performed scATAC-seq on human fetal retina and human embryonic stem cell (hESC)-derived retinal organoids (Table S1), including 7 fetal retinas (2 that were cultured for 4 days in vitro [DIV]) and 5 organoid samples containing approximately …
… Specifically, NOAF but not pre-AF is associated with a higher risk of 30-day mortality, stroke, and extended LOS after TAVR/TAVI. … Two studies revealed statistically significant findings concerning the incidence of stroke events in patients …
… This paper presents a cross-sectional analysis of COVID-19 vaccine hesitancy among parents of children who have undergone a hematopoietic stem cell transplant. Approval was obtained from our local institutional review board to conduct this …
… and use of OAC in patients with TAVR and AF, we excluded all patients with a prior mechanical valve, prior stroke within 1 year, in‐… In an analysis from a large clinical data registry of US patients with AF undergoing TAVR, we found that the 1‐year …
Tissue-resident lymphoid cells (TLCs) span the spectrum of innate-to-adaptive immune function. Unlike traditional, circulating lymphocytes that are continuously generated from hematopoietic stem cells (HSCs), many TLCs are of fetal origin and …
… Despite a known high prevalence of anemia and periprocedural stroke risk among TAVR patients, few studies have evaluated the relationship between anemia and new ischemic lesions detected by DW-MRI. In this study, we revealed that …
… Second, in a study that reported the occurrence of stroke as a primary outcome, it is notable that there is no reporting on the use of neurologic … This device has shown reduced cerebral lesions on radiographic investigation after TAVR, and was …
… Murine Todr1 is expressed by a range of stem cell types, including embryonic stem cell and HSCs (not shown). Analysis of an RNAseq dataset and a ChIPseq dataset from human embryonic stem cells confirms that there is transcription of this …
When the FDA announced it was no longer authorizing two COVID-19 monoclonal antibody drugs in the U.S., Governor DeSantis, along with a many Republicans objected, saying they did this without data. However, recent lab studies strongly suggest the treatments will not help omicron-infected people.
Here are some of the latest articles we've posted in the Behavioral Science channel.
The management of immunoglobulin light chain (AL) amyloidosis is complex. Emerging data has shown promising results for several novel agents. We review the management of AL amyloidosis including factors that determine transplant eligibility …
Adult T-cell leukemia/lymphoma (ATL) is a refractory peripheral T-cell lymphoma (PTCL). Treatment with chemotherapy alone is associated with an extremely poor prognosis. Allogeneic stem cell transplantation (SCT) is the only modality shown to achieve long-term …
… Several types of MSC-EVs were reported in recent years, and in this study, we chose bone marrow mesenchymal stem cell-derived EVs (… Therefore, even AMSC-EVs are relatively easier to obtain [38], BMSC-EV is still the first choice among all these …
Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) affecting the liver is a rare, possibly life-threatening complication of hematopoietic stem cell transplantation (HSCT). Sinusoidal endothelial cell (SEC) damage …
… , stem cell marker expression, cell invasion, and sphere formation. Furthermore, in vivo knockdown completely inhibited tumor growth in mouse xenograft model. We propose that cytoplasmic SOX9-mediated cell death suppression would contribute to …
… pluripotent stem cells-mesenchymal stem cell-like cells; … stem cell surface molecular markers (CD34 and CD45), macrophage molecular marker CD14, lymphocyte molecular marker CD19, and HLA-DR (Figure 2), which were in …
Large study in England suggests need for increased monitoring of COVID-19 patients after discharge.
… Most of our current knowledge on stem cell systems and their regulatory microenvironments … In brief, we have learned from the so-called “model systems” that the stem cell niche refers … times) are carefully regulated to ensure appropriate …
… biotherapies, including drug delivery, vaccine delivery, gene therapy, and stem cell therapy, are documented in this study. For drug delivery, … For stem cell therapy, the applications of biomaterials in creating 3D culture systems for guiding stem cell …
The latest research news from the Health Disparities Channel.
… Adipose-derived stem cell (ADSC) or crushed adipose tissue injection into the joint cavity reportedly improve knee function and symptoms, including pain. Stem cell spheroids may be promising treatment options due to their anti-inflammatory …
… Evidence of allogeneic haematopoietic stem-cell transplantation being beneficial in patients with late-infantile MLD appears to be very … Furthermore, allogeneic haematopoietic stem-cell transplantation did not slow down disease progression in …
… This review provides an overview of stem cell-based disease models in neuropsychiatry and considers the advantages and challenges surrounding the contributions … Summary of the key elements and challenges for each stem-cell-based …
Purpose: Graft-versus-host disease (GVHD) is an important complication after human leukocyte antigen (HLA) haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT), which may lead to poor prognosis. Our study intends to …
… RICH1 inhibits stem cell-like properties in breast cancer and maintains the normal epithelial architecture of … 3: RICH1 inhibits stem cell-like properties in breast cancer and maintains the normal epithelial architecture … RICH1 inhibits stem cell-like …
… ) to ask if this is because senescent cells in stem cell niches impair precursor-mediated tissue maintenance. We demonstrate an aging-dependent accumulation of senescent cells, largely senescent NPCs, within the hippocampal stem cell niche …
Welensky did not say 75% percent of all COVID-19 deaths in the U.S. had at least four comorbidities. The shared social media posts imply that deaths from COVID-19 are being over-counted. We find this claim to be misleading, having taken Walensky's interview out of context. It is clear from watching the full clip, Dr. Welensky was referring to the percentage of fully vaccinated people who died from COVID-19.
… Second, in a study that reported the occurrence of stroke as a primary outcome, it is notable that there is no reporting on the use of neurologic … This device has shown reduced cerebral lesions on radiographic investigation after TAVR, and was …
… Despite a known high prevalence of anemia and periprocedural stroke risk among TAVR patients, few studies have evaluated the relationship between anemia and new ischemic lesions detected by DW-MRI. In this study, we revealed that …
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